Role of inflammatory chemokines in hypertension (original) (raw)

Mikolajczyk, Tomasz P., Szczepaniak, Piotr, Vidler, Francesca, Maffia, Pasquale ORCID: https://orcid.org/0000-0003-3926-4225, Graham, Gerard J. ORCID: https://orcid.org/0000-0002-7801-204X and Guzik, Tomasz J.(2021) Role of inflammatory chemokines in hypertension.Pharmacology and Therapeutics, 223, 107799. (doi: 10.1016/j.pharmthera.2020.107799) (PMID:33359600)

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Abstract

Hypertension is associated with immune cells activation and their migration into the kidney, vasculature, heart and brain. These inflammatory mechanisms are critical for blood pressure regulation and mediate target organ damage, creating unique novel targets for pharmacological modulation. In response to angiotensin II and other pro-hypertensive stimuli, the expression of several inflammatory chemokines and their receptors is increased in the target organs, mediating homing of immune cells. In this review, we summarize the contribution of key inflammatory chemokines and their receptors to increased accumulation of immune cells in target organs and effects on vascular dysfunction, remodeling, oxidative stress and fibrosis, all of which contribute to blood pressure elevation. In particular, the role of CCL2, CCL5, CXCL8, CXCL9, CXCL10, CXCL11, CXCL16, CXCL1, CX3CL1, XCL1 and their receptors in the context of hypertension is discussed. Recent studies have tested the efficacy of pharmacological or genetic targeting of chemokines and their receptors on the development of hypertension. Promising results indicate that some of these pathways may serve as future therapeutic targets to improve blood pressure control and prevent target organ consequences including kidney failure, heart failure, atherosclerosis or cognitive impairment.

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Funder and Project Information

Defining the individual and integrated roles of inflammatory chemokine receptors (iCCRs) in atherosclerosis

Pasquale Maffia

PG/19/84/34771

CAMS - Cardiovascular Science

BHF centre of excellence

Rhian Touyz

RE/13/5/30177

Institute of Cardiovascular & Medical Sciences

Institutional Strategic Support Fund (2016)

Anna Dominiczak

204820/Z/16/Z

Institute of Cardiovascular & Medical Sciences

Defining chemokine receptor involvement in the myelomonocytic inflammatory response

Gerard Graham

217093/Z/19/Z

III - Immunology

The ACKR2-CCR2 axis in development and disease

Gerard Graham

MR/M019764/1

III - Immunology

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