Demographic, multi-morbidity and genetic impact on myocardial involvement and its recovery from COVID-19: protocol design of COVID-HEART—a UK, multicentre, observational study (original) (raw)
Gorecka, M. et al. (2021) Demographic, multi-morbidity and genetic impact on myocardial involvement and its recovery from COVID-19: protocol design of COVID-HEART—a UK, multicentre, observational study.Journal of Cardiovascular Magnetic Resonance, 23, 77. (doi: 10.1186/s12968-021-00752-1) (PMID:34112195) (PMCID:PMC8190746)
Abstract
Abstract: Background: Although coronavirus disease 2019 (COVID-19) is primarily a respiratory illness, myocardial injury is increasingly reported and associated with adverse outcomes. However, the pathophysiology, extent of myocardial injury and clinical significance remains unclear. Methods: COVID-HEART is a UK, multicentre, prospective, observational, longitudinal cohort study of patients with confirmed COVID-19 and elevated troponin (sex-specific > 99th centile). Baseline assessment will be whilst recovering in-hospital or recently discharged, and include cardiovascular magnetic resonance (CMR) imaging, quality of life (QoL) assessments, electrocardiogram (ECG), serum biomarkers and genetics. Assessment at 6-months includes repeat CMR, QoL assessments and 6-min walk test (6MWT). The CMR protocol includes cine imaging, T1/T2 mapping, aortic distensibility, late gadolinium enhancement (LGE), and adenosine stress myocardial perfusion imaging in selected patients. The main objectives of the study are to: (1) characterise the extent and nature of myocardial involvement in COVID-19 patients with an elevated troponin, (2) assess how cardiac involvement and clinical outcome associate with recognised risk factors for mortality (age, sex, ethnicity and comorbidities) and genetic factors, (3) evaluate if differences in myocardial recovery at 6 months are dependent on demographics, genetics and comorbidities, (4) understand the impact of recovery status at 6 months on patient-reported QoL and functional capacity. Discussion: COVID-HEART will provide detailed characterisation of cardiac involvement, and its repair and recovery in relation to comorbidity, genetics, patient-reported QoL measures and functional capacity.
| Item Type: | Articles |
|---|---|
| Additional Information: | COVID-HEART is funded by the National Institute for Health Research (NIHR) and UK Research and Innovation (UKRI) COVID-19 Rapid Response Rolling Call (Grant Number COV0254), and sponsored by the University of Leeds, UK. Funding for the translation of the patient information leaflets into non-English languages was provided by the West Yorkshire and Humber Clinical Research Network (CV070). |
| Keywords: | Study Protocol, ISRCTN 58667920, ISRCTN, COVID-19, Coronavirus, cardiovascular magnetic resonance, myocarditis, myopericarditis, myocardial infarction, myocardial injury, myocardial inflammation, myocardial repair, cardiovascular disease. |
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Macfarlane, Professor Peter and Berry, Professor Colin and McConnachie, Professor Alex |
| Authors: | Gorecka, M., McCann, G. P., Berry, C., Ferreira, V. M., Moon, J. C., Miller, C. A., Chiribiri, A., Prasad, S., Dweck, M. R., Bucciarelli-Ducci, C., Dawson, D., Fontana, M., Macfarlane, P. W., McConnachie, A., Neubauer, S., Greenwood, J. P., Swoboda, P., Steeds, R., Fairbairn, T., Flett, A., Green, T., Cole, G., McDiarmid, A., Bunce, N., Kanagala, P., Bellenger, N., Ninan, T., Alfakih, K., and Moon, J. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic HealthCollege of Medical Veterinary and Life Sciences > School of Health & Wellbeing > Robertson Centre |
| Journal Name: | Journal of Cardiovascular Magnetic Resonance |
| Publisher: | BioMed Central |
| ISSN: | 1097-6647 |
| ISSN (Online): | 1532-429X |
| Copyright Holders: | Copyright © 2021 The Authors |
| First Published: | First published in Journal of Cardiovascular Magnetic Resonance 23: 77 |
| Publisher Policy: | Reproduced under a Creative Commons License |
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Funder and Project Information
COVID-HEART - Sub Study 1 Demographic, multi-morbidity and genetic impact in myocardial involvement and its recovery from COVID-19
Colin Berry
COV0254, CD20/133244
SHW - Robertson Centre for Biostatistics
Deposit and Record Details
| ID Code: | 243890 |
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| Depositing User: | Publications Router |
| Datestamp: | 17 Jul 2024 13:41 |
| Last Modified: | 18 Jul 2024 01:30 |
| Date of acceptance: | 2 April 2021 |
| Date of first online publication: | 10 June 2021 |
| Date Deposited: | 17 July 2024 |
| Data Availability Statement: | Yes |