Pathways for the influx of molecules into cercariae of Schistosoma mansoni during skin penetration (original) (raw)

Thornhill, J.A., McVeigh, P., Jurberg, A.D. and Kusel, J.R.(2010) Pathways for the influx of molecules into cercariae of Schistosoma mansoni during skin penetration.Parasitology, pp. 1-10. (doi: 10.1017/S0031182009991983)

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Publisher's URL: http://dx.doi.org/10.1017/S0031182009991983

Abstract

It has been observed that fluorescent membrane-impermeant molecules can enter the cercariae as they penetrate mouse skin. The hypothesis to be tested was that such molecules, which included Lucifer Yellow and a variety of fluorescent dextrans, entered the parasite through the nephridiopore and excretory tubules as well as through the surface membrane. FITC-labelled poly-L-lysine (molecular weight 10 kDa), added at 4C. Since increased uptake of propidium iodide occurs when membranes become permeable, the surface membrane could also be a pathway of transport of the membrane-impermeant molecules into the schistosomulum

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