Long-term outcomes following severe COVID-19 infection: a propensity matched cohort study (original) (raw)

McPeake, J. et al. (2021) Long-term outcomes following severe COVID-19 infection: a propensity matched cohort study.BMJ Open Respiratory Research, 8, e001080. (doi: 10.1136/bmjresp-2021-001080)

Abstract

Background: There are limited data describing the long-term outcomes of severe COVID-19. We aimed to evaluate the long-term psychosocial and physical consequences of severe COVID-19 for patients. Methods: We conducted a multicentre observational cohort study; between 3 and 7 months posthospital discharge, patients who had been admitted to critical care due to severe COVID-19 were invited to an established recovery service. Standardised questionnaires concerning emotional, physical and social recovery, including information on employment, were completed by patients. Using propensity score matching, we explored outcomes between patients admitted to critical care with and without COVID-19, using data from the same recovery programme. Results: Between July 2020 and December 2020, 93 patients who had been admitted to critical with COVID-19 participated. Emotional dysfunction was common: 46.2% of patients had symptoms of anxiety and 34.4% symptoms of depression. At follow-up 53.7% of previously employed patients had returned to employment; there was a significant difference in return to employment across the socio-economic gradient, with lower numbers of patients from the most deprived areas returning to employment (p=0.03). 91 (97.8%) COVID-19 patients were matched with 91 non-COVID-19 patients. There were no significant differences in any measured outcomes between the two cohorts. Interpretation: Emotional and social problems are common in survivors of severe COVID-19 infection. Coordinated rehabilitation is required to ensure patients make an optimal recovery.

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Funder and Project Information

Project Code

Award No

Project Name

Principal Investigator

Funder's Name

Funder Ref

Lead Dept

Improving health and social care integration delivery in the acute care environment

Joanne McPeake

RG88620

HW - MRC/CSO Social and Public Health Sciences Unit

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