Systematic review: association between circulating microRNA expression & stroke (original) (raw)
Fullerton, Josie L. 
ORCID: https://orcid.org/0000-0002-1967-9522, Thomas, Josephine M., Gonzalez-Trueba, Laura, Trivett, Cara, Van Kralingen, Josie C., Allan, Stuart M., Quinn, Terence J. ORCID: https://orcid.org/0000-0003-1401-0181 and Work, Lorraine M. ORCID: https://orcid.org/0000-0002-6462-4109(2022) Systematic review: association between circulating microRNA expression & stroke.Journal of Cerebral Blood Flow and Metabolism, 42(6), pp. 935-951. (doi: 10.1177/0271678X221085090) (PMID:35240874) (PMCID:PMC9121526)
Abstract
This systematic review aimed to establish the range and quality of clinical and preclinical evidence supporting the association of individual microRNAs, and the use of microRNA expression in the diagnosis and prognosis of ischaemic or haemorrhagic stroke. Electronic databases were searched from 1993 to October 2021, using key words relevant to concepts of stroke and microRNA. Studies that met specific inclusion and exclusion criteria were selected for data extraction. To minimise erroneous associations, findings were restricted to microRNAs reported to change in more than two independent studies. Of the papers assessed, 155 papers reported a change in microRNA expression observed in more than two independent studies. In ischaemic studies, two microRNAs were consistently differentially expressed in clinical samples (miR-29b & miR-146a) and four were altered in preclinical samples (miR-137, miR-146a, miR-181b & miR-223-3p). Across clinical and preclinical haemorrhagic studies, four microRNAs were downregulated consistently (miR-26a, miR-126, miR-146a & miR-155). Across included studies, miR-126 and miR-146a were the only two microRNAs to be differentially expressed in clinical and preclinical cohorts following ischaemic or haemorrhagic stroke. Further studies, employing larger populations with consistent methodologies, are required to validate the true clinical value of circulating microRNAs as biomarkers of ischaemic and haemorrhagic stroke.
| Item Type: | Articles |
|---|---|
| Additional Information: | The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: this work was supported by the Chief Scientific Office [Project grant TCS/18/13] (TJQ & LMW), the British Heart Foundation (BHF) 4 Year PhD Studentship Awards FS/19/ 56/34893 (CT) and FS/4yPhD/F/20/34127 (LGT) and by an Engineering and Physical Science Research Council (EPSRC, UK) and Medical Research Council (MRC, UK) Centre for Doctoral Training in Regenerative Medicine Studentship Grant [No. EP/L014904/1] (JMT). |
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Trivett, Miss Cara and Work, Professor Lorraine and Van Kralingen, Ms Josie and Quinn, Professor Terry and Fullerton, Dr Josie |
| Authors: | Fullerton, J. L., Thomas, J. M., Gonzalez-Trueba, L., Trivett, C., Van Kralingen, J. C., Allan, S. M., Quinn, T. J., and Work, L. M. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health |
| Journal Name: | Journal of Cerebral Blood Flow and Metabolism |
| Publisher: | SAGE Publications |
| ISSN: | 0271-678X |
| ISSN (Online): | 1559-7016 |
| Published Online: | 03 March 2022 |
| Copyright Holders: | Copyright © 2022 The Authors |
| First Published: | First published in Journal of Cerebral Blood Flow and Metabolism 42(6): 935-951 |
| Publisher Policy: | Reproduced under a Creative Commons License |
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Funder and Project Information
Extracellular vesicle mediated microRNA delivery as a therapeutic for ischaemic stroke
Lorraine Work
TCS/18/13
CAMS - Cardiovascular Science
BHF 4Yr PhD Studentship Award 2109
Rhian Touyz
FS/19/56/34893
CAMS - Cardiovascular Science
BHF 4Yr PhD Studentship Award 2020
Rhian Touyz
FS/4yPhD/F/20/34127
CAMS - Cardiovascular Science
Deposit and Record Details
| ID Code: | 264896 |
|---|---|
| Depositing User: | Miss Valerie McCutcheon |
| Datestamp: | 07 Feb 2022 11:41 |
| Last Modified: | 10 Aug 2022 15:34 |
| Date of acceptance: | 6 February 2022 |
| Date of first online publication: | 3 March 2022 |
| Date Deposited: | 7 February 2022 |
| Data Availability Statement: | No |