Adjudicated myocarditis and multisystem illness trajectory in healthcare workers post-COVID-19 (original) (raw)

Sykes, R. et al. (2023) Adjudicated myocarditis and multisystem illness trajectory in healthcare workers post-COVID-19.Open Heart, 10(1), e002192. (doi: 10.1136/openhrt-2022-002192) (PMID:36822817) (PMCID:PMC9950584)

Abstract

Background: We investigated the associations of healthcare worker status with multisystem illness trajectory in hospitalised post-COVID-19 individuals. Methods and results: One hundred and sixty-eight patients were evaluated 28–60 days after the last episode of hospital care. Thirty-six (21%) were healthcare workers. Compared with non-healthcare workers, healthcare workers were of similar age (51.3 (8.7) years vs 55.0 (12.4) years; p=0.09) more often women (26 (72%) vs 48 (38%); p<0.01) and had lower 10-year cardiovascular risk (%) (8.1 (7.9) vs 15.0 (11.5); p<0.01) and Coronavirus Clinical Characterisation Consortium in-hospital mortality risk (7.3 (10.2) vs 12.7 (9.8); p<0.01). Healthcare worker status associated with less acute inflammation (peak C reactive protein 48 mg/L (IQR: 14–165) vs 112 mg/L (52–181)), milder illness reflected by WHO clinical severity score distribution (p=0.04) and shorter duration of admission (4 days (IQR: 2–6) vs 6 days (3–12)). In adjusted multivariate logistic regression analysis, healthcare worker status associated with a binary classification (probable/very likely vs not present/unlikely) of adjudicated myocarditis (OR: 2.99; 95% CI (1.01 to 8.89) by 28–60 days postdischarge). After a mean (SD, range) duration of follow-up after hospital discharge of 450 (88) days (range 290, 627 days), fewer healthcare workers died or were rehospitalised (1 (3%) vs 22 (17%); p=0.038) and secondary care referrals for post-COVID-19 syndrome were common (42%) and similar to non-healthcare workers (38%; p=0.934). Conclusion: Healthcare worker status was independently associated with the likelihood of adjudicated myocarditis, despite better antecedent health. Two in five healthcare workers had a secondary care referral for post-COVID-19 syndrome. Trial registration number: NCT04403607.

Item Type: Articles
Status: Published
Refereed: Yes
Glasgow Author(s) Enlighten ID: Welsh, Professor Paul and Rankin, Dr Alastair and Bagot, Dr Catherine and Lowe, Dr David and Sattar, Professor Naveed and Bulluck, Dr Heerajnarain and Delles, Professor Christian and Robertson, Dr Keith and McConnachie, Professor Alex and Allwood-Spiers, Sarah and McIntosh, Dr Alasdair and Lang, Professor Ninian and Morrow, Dr Andrew and Bayes, Dr Hannah and Mayne, Dr Kaitlin and Corcoran, Dr David and Wereski, Dr Ryan and Hall Barrientos, Dr Pauline and McGinley, Dr Christopher and Berry, Professor Colin and Mangion, Dr Kenneth and Macfarlane, Professor Peter and Gibson, Dr Vivienne and Blyth, Professor Kevin and Touyz, Professor Rhian and Sykes, Dr Robert and Veldtman, Professor Gruschen and Church, Dr Colin and Carrick, Dr David and Weeden, Dr Sarah and Ho, Professor Antonia and Kamdar, Ms Anna and Mark, Professor Patrick and Watkins, Dr Stuart and Findlay, Dr Iain and Payne, Dr Alexander and Roditi, Dr Giles and Gillespie, Dr Lynsey
Authors: Sykes, R., Morrow, A. J., McConnachie, A., Kamdar, A., Bagot, C., Bayes, H., Blyth, K. G., Briscoe, M., Bulluck, H., Carrick, D., Church, C., Corcoran, D., Delles, C., Findlay, I., Gibson, V. B., Gillespie, L., Grieve, D., Hall Barrientos, P., Ho, A., Lang, N. N., Lowe, D. J., Lennie, V., MacFarlane, P., Mayne, K. J., Mark, P., McIntosh, A., McGeoch, R., McGinley, C., Mckee, C., Nordin, S., Payne, A., Rankin, A., Robertson, K. E., Ryan, N., Roditi, G. H., Sattar, N., Stobo, D. B., Allwood-Spiers, S., Touyz, R., Veldtman, G., Weeden, S., Watkins, S., Welsh, P., Wereski, R., Mangion, K., and Berry, C.
College/School: College of Medical Veterinary and Life Sciences > School of Cancer SciencesCollege of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic HealthCollege of Medical Veterinary and Life Sciences > School of Health & Wellbeing > Robertson CentreCollege of Medical Veterinary and Life Sciences > School of Infection & ImmunityCollege of Medical Veterinary and Life Sciences > School of Infection & Immunity > Centre for Virus ResearchCollege of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing
Journal Name: Open Heart
Publisher: BMJ Publishing Group
ISSN: 2053-3624
ISSN (Online): 2053-3624
Published Online: 23 February 2023
Copyright Holders: Copyright © 2023 The Authors
First Published: First published in Open Heart 10(1): e002192
Publisher Policy: Reproduced under a Creative Commons License

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Funder and Project Information

CSO covid 19 portfolio

Iain McInnes

COV/GLA/Portfolio

III - Immunology

BHF Centre of Excellence

Colin Berry

RE/18/6/34217

CAMS - Cardiovascular Science

Deposit and Record Details

ID Code: 290671
Depositing User: Dr Mary Donaldson
Datestamp: 30 Jan 2023 10:10
Last Modified: 09 Jan 2026 16:42
Date of acceptance: 27 January 2023
Date of first online publication: 23 February 2023
Date Deposited: 27 February 2023
Data Availability Statement: Yes