Placental syndromes and maternal cardiovascular health (original) (raw)
Casey, Helen, Dennehy, Natalie, Fraser, Abigail, Lees, Christoph, McEniery, Carmel M., Scott, Kayley 
ORCID: https://orcid.org/0000-0001-8641-6821, Wilkinson, Ian B. and Delles, Christian ORCID: https://orcid.org/0000-0003-2238-2612(2023) Placental syndromes and maternal cardiovascular health.Clinical Science, 137(16), pp. 1211-1224. (doi: 10.1042/CS20211130) (PMID:37606085)
Abstract
The placental syndromes gestational hypertension, preeclampsia and intrauterine growth restriction are associated with an increased cardiovascular risk to the mother later in life. In this review, we argue that a woman’s pre-conception cardiovascular health drives both the development of placental syndromes and long-term cardiovascular risk but acknowledge that placental syndromes can also contribute to future cardiovascular risk independent of pre-conception health. We describe how preclinical studies in models of preeclampsia inform our understanding of the links with later cardiovascular disease, and how current pre-pregnancy studies may explain relative contributions of both pre-conception factors and the occurrence of placental syndromes to long-term cardiovascular disease.
| Item Type: | Articles |
|---|---|
| Additional Information: | This work has been supported by grants from Wellcome (221774/Z/20/Z). CD is supported by the British Heart Foundation (RE/18/6/34217). CCL is supported by the NIHR Biomedical Research Centre (BRC) based at Imperial College Healthcare NHS Trust and Imperial College London. |
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Casey, Dr Helen and Delles, Professor Christian and Scott, Dr Kit and Wilkinson, Dr Ian |
| Authors: | Casey, H., Dennehy, N., Fraser, A., Lees, C., McEniery, C. M., Scott, K., Wilkinson, I. B., and Delles, C. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic HealthCollege of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing |
| Journal Name: | Clinical Science |
| Publisher: | Portland Press |
| ISSN: | 0143-5221 |
| ISSN (Online): | 1470-8736 |
| Published Online: | 22 August 2023 |
| Copyright Holders: | Copyright © 2023 The Authors |
| First Published: | First published in Clinical Science 137(16): 1211-1224 |
| Publisher Policy: | Reproduced under a Creative Commons License |
University Staff: Request a correction | Enlighten Editors: Update this record
Funder and Project Information
BHF Centre of Excellence
Colin Berry
RE/18/6/34217
SCMH - Cardiovascular & Metabolic Health
Deposit and Record Details
| ID Code: | 304209 |
|---|---|
| Depositing User: | Ms Jacqui Brannan |
| Datestamp: | 07 Aug 2023 15:09 |
| Last Modified: | 26 Mar 2024 14:47 |
| Date of acceptance: | 7 August 2023 |
| Date of first online publication: | 22 August 2023 |
| Date Deposited: | 7 August 2023 |
| Data Availability Statement: | Yes no data confirmed |