Non-pharmacological interventions to improve cardiovascular risk factors in people with diabetic foot disease: a systematic review and meta-analysis (original) (raw)
Highton, P. et al. (2024) Non-pharmacological interventions to improve cardiovascular risk factors in people with diabetic foot disease: a systematic review and meta-analysis.Diabetes Research and Clinical Practice, 209, 111590. (doi: 10.1016/j.diabres.2024.111590) (PMID:38403175)
Abstract
Cardiovascular disease (CVD) risk in those with diabetic foot disease is very high. Non-pharmacological interventions may improve this risk, though no previous evidence synthesis has been completed. This systematic review aimed to investigate the impact of non-pharmacological interventions on CVD risk factors in diabetic ulcer disease. Multiple databases and trials registers were searched from inception to December 6th 2023. We included reports of randomised controlled trials investigating the impact of non-pharmacological interventions on cardiovascular risk in those with type 1 or type 2 diabetes and current or previous diabetic foot disease. Twenty studies were included. Extracted data included: study design and setting; participant sociodemographic factors; and change in cardiovascular risk factors. Data were synthesised using random effects meta-analyses and narrative syntheses. Interventions included nutritional supplementation, collaborative care, hyperbaric oxygen therapy, patient education, nurse-led intervention, self-management, family support, relaxation and exercise, over a median duration of 12 weeks. Significant post-intervention changes were observed in fasting plasma glucose, serum insulin levels, insulin sensitivity and resistance, glycated haemoglobin, triglycerides, total cholesterol, low-density lipoprotein-cholesterol and C-reactive protein. No effects were detected in very low- or high-density lipoprotein-cholesterol or body mass index. Non-pharmacological interventions show promise in improving CVD risk in diabetic foot disease.
| Item Type: | Articles |
|---|---|
| Additional Information: | This project is funded by the National Institute for Health and Care Research (NIHR) under its Programme Grants for Applied Research Programme and Diabetes UK (NIHR202021). The views expressed are those of the author(s) and not necessarily those of the NIHR or the Department of Health and Social Care. |
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Petrie, Professor John |
| Creator Roles: | Petrie, J.Conceptualization, Investigation, Writing – review and editing, Funding acquisition, Methodology |
| Authors: | Highton, P., Almaqhawi, A., Oroko, M., Sathanapally, H., Gray, L., Davies, M., Webb, D., Game, F., Petrie, J., Tesfaye, S., Valabhji, J., Gillies, C., and Khunti, K. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Health & Wellbeing > Robertson Centre |
| Journal Name: | Diabetes Research and Clinical Practice |
| Publisher: | Elsevier |
| ISSN: | 0168-8227 |
| ISSN (Online): | 0168-8227 |
| Published Online: | 24 February 2024 |
| Copyright Holders: | Copyright: © 2024 The Authors |
| First Published: | First published in Diabetes Research and Clinical Practice 209: 111590 |
| Publisher Policy: | Reproduced under a Creative Commons licence |
University Staff: Request a correction | Enlighten Editors: Update this record
Deposit and Record Details
| ID Code: | 322480 |
|---|---|
| Depositing User: | Publications Router |
| Datestamp: | 29 Apr 2024 13:02 |
| Last Modified: | 25 Jul 2024 08:52 |
| Date of acceptance: | 22 February 2024 |
| Date of first online publication: | 24 February 2024 |
| Date Deposited: | 29 April 2024 |
| Data Availability Statement: | No |