Retrospective cohort study: scope for improvement - barriers to post-polypectomy surveillance in the integrated technologies for improved polyp surveillance cohort (original) (raw)
Mathews, C. et al. (2025) Retrospective cohort study: scope for improvement - barriers to post-polypectomy surveillance in the integrated technologies for improved polyp surveillance cohort.Alimentary Pharmacology and Therapeutics, 61(8), pp. 1381-1386. (doi: 10.1111/apt.18514) (PMID:39831571) (PMCID:PMC11950799)
Abstract
Background: Adherence to post-polypectomy surveillance is poor despite evidence that it is associated with lower risk of future colorectal cancer. Methods: We evaluated 6,210 bowel screening participants between 2009-2016 in NHS Greater Glasgow and Clyde to assess potential barriers to post-polypectomy surveillance. Results: Increasing deprivation (Scottish Index of Multiple Deprivation quintile 1 vs 5; OR 1.68; p < 0.001), and increasing comorbidity (Charlson Comorbidity Index 1-2 vs 3-4; OR 1.80; p < 0.001, vs ≥ 5; OR 3.31; p < 0.001), were associated with non-surveillance in British Society of Gastroenterology 2002 intermediate/high-risk patients, while ACE-Inhibitor (OR 0.78; p < 0.001) and aspirin use (OR 0.34; p < 0.001) were associated with undergoing surveillance. The most deprived patients receiving surveillance had more metachronous polyps (54.0% vs 49.3%) and cancer (1.1% vs 0.4%) (p = 0.044). Discussion: Patients from more socioeconomically deprived areas are less likely to have appropriate post-polypectomy surveillance, and are more likely to have metachronous polyps and colorectal cancer even when they do. Conclusion: Surveillance strategies must take into account factors including socioeconomic deprivation and comorbidity exist to improve surveillance uptake in this group through the design of targeted interventions which move away from the current “one size fits all” approach.
| Item Type: | Articles |
|---|---|
| Additional Information: | This work is supported by the INtegrated TeChnologies for Improved Polyp SurveillancE (INCISE) project. The project is jointly funded by Innovate UK, on behalf of UK Research and Innovation (UKRI), and Cancer Research UK’s Enabling Integrated Diagnostics for Early Detection competition (project number: 105858), and Innovate UK’s Innovation Accelerator Programme (project number 10054829). |
| Keywords: | Polyp, adenoma, colorectal, surveillance, deprivation. |
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Edwards, Professor Joanne and Tham, Dr Alexander and Johnstone, Dr Mark and Parsons, Dr Emma and McSorley, Dr Stephen and Lynch, Dr Gerard and Robb, Professor Katie |
| Creator Roles: | Johnstone, M.Data curation, Investigation, Methodology, Resources, Software, Writing – review and editingTham, A.Data curation, Investigation, Writing – review and editingParsons, E.Methodology, Project administration, Writing – review and editingRobb, K.Methodology, Writing – review and editingLynch, G.Conceptualization, Funding acquisition, Project administration, Supervision, Writing – review and editingEdwards, J.Conceptualization, Funding acquisition, Project administration, Supervision, Writing – review and editingMcSorley, S.Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Software, Supervision, Writing – original draft |
| Authors: | Mathews, C., Nauman, A., Johnstone, M., Stoops, R., Tham, A., Parsons, E. C., Robb, K. A., Sloan, W., Lynch, G., Edwards, J., and McSorley, S. T. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Cancer SciencesCollege of Medical Veterinary and Life Sciences > School of Health & Wellbeing > Mental Health and WellbeingCollege of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing |
| Journal Name: | Alimentary Pharmacology and Therapeutics |
| Publisher: | Wiley |
| ISSN: | 0269-2813 |
| ISSN (Online): | 1365-2036 |
| Published Online: | 20 January 2025 |
| Copyright Holders: | Copyright © 2025 The Author(s) |
| First Published: | First published in Alimentary Pharmacology and Therapeutics 61(8):1381-1386 |
| Publisher Policy: | Reproduced under a Creative Commons licence |
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Funder and Project Information
Integrated Technologies for Improved Polyp Surveillance (INCISE) V2.0
Joanne Edwards
10054829
SCS - Therapeutic Science Research
Integrated Technologies for Improved Polyp Surveillance (INCISE)
Joanne Edwards
105858
SCS - Translational Pharmacology Lab
Deposit and Record Details
| ID Code: | 345448 |
|---|---|
| Depositing User: | Mr Alastair Arthur |
| Datestamp: | 17 Jan 2025 14:37 |
| Last Modified: | 14 Jul 2025 09:28 |
| Date of acceptance: | 13 January 2025 |
| Date of first online publication: | 20 January 2025 |
| Date Deposited: | 17 January 2025 |
| Data Availability Statement: | Yes |