Somatic CAG repeat expansion in blood associates with biomarkers of neurodegeneration in Huntington’s disease decades before clinical motor diagnosis (original) (raw)

Additional Information:

Funding for this study was provided by the following: Wellcome Collaborative Award (223082/Z/21/Z to S.J.T., R.I.S., M.F., M.J.M., N.Z.H., M.L., C.L., K.F., T.W.R., J.B.R., B.J.S., D.G.M. and D.R.L.); the CHDI Foundation (a not-for-profit organization dedicated to finding treatments for Huntington’s disease) funded CSF collection; the UK Dementia Research Institute (DRI; London, UK) through UK DRI, principally funded by the UK Medical Research Council; University College London Hospital/University College London (London, UK), supported by the National Institute for Health and Care Research (NIHR) University College London Hospitals Biomedical Research Centre; Wellcome Trust (220258 to J.B.R.); Medical Research Council (MC_UU_00030/14 and MR/T033371/1 to J.B.R.) and NIHR Cambridge Biomedical Research Centre (NIHR203312 to J.B.R.). H.Z. is a Wallenberg Scholar and a Distinguished Professor at the Swedish Research Council. J.G. is supported by Alzheimerfonden (AF-980746) and Stiftelsen för Gamla tjänarinnor (2022-01324).

Authors:

Scahill, R. I., Farag, M., Murphy, M. J., Hobbs, N. Z., Leocadi, M., Langley, C., Knights, H., Ciosi, M., Fayer, K., Nakajima, M., Thackeray, O., Gobom, J., Rönnholm, J., Weiner, S., Hassan, Y. R., Ponraj, N. K.P., Estevez-Fraga, C., Parker, C. S., Malone, I. B., Hyare, H., Long, J. D., Heslegrave, A., Sampaio, C., Zhang, H., Robbins, T. W., Zetterberg, H., Wild, E. J., Rees, G., Rowe, J. B., Sahakian, B. J., Monckton, D. G., Langbehn, D. R., and Tabrizi, S. J.

First Published:

First published in Nature Medicine 31(3):807-818

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Reproduced under a Creative Commons licence