Post-processing of coronary and myocardial spatial data (original) (raw)
Mackenzie, Jay A. 
ORCID: https://orcid.org/0000-0002-0144-1479, Miller, Megan J., Olufsen, Mette S. and Hill, Nicholas A. ORCID: https://orcid.org/0000-0003-3079-828X(2025) Post-processing of coronary and myocardial spatial data.Computers in Biology and Medicine, 196(Part C), 110868. (doi: 10.1016/j.compbiomed.2025.110868)
Abstract
Numerical simulations of real-world phenomena require a computational scheme and a computational domain. In the context of haemodynamics, the computational domain is the blood vessel network through which blood flows. Such networks contain millions of vessels that are joined in series and in parallel. It is computationally unfeasible to explicitly simulate blood flow throughout the network. From a single porcine left coronary arterial tree, we develop a data pipeline to obtain computational domains for haemodynamic simulations in the myocardium from a graph representing a partial coronary arterial tree. In addition, we develop a method to ascertain which subregions of the left-ventricular wall are more likely to be perfused via a given artery, using a comparison with the American Heart Association division of the left ventricle for validation.
| Item Type: | Articles |
|---|---|
| Additional Information: | This research was supported by the UK Engineering and Physical Sciences Research Council (EP/N014642/1, EP/T017899/1), and the National Science Foundation, United States via award 1615820. |
| Keywords: | Coronary arterial system, tree pruning, arterial networks, myocardial perfusion, Strahler order. |
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Hill, Professor Nicholas and Mackenzie, Dr Jay |
| Creator Roles: | Mackenzie, J. A.Writing – original draft, Visualization, Validation, Software, Methodology, Formal analysis, Data curation, ConceptualizationHill, N. A.Writing – review and editing, Supervision, Resources, Funding acquisition |
| Authors: | Mackenzie, J. A., Miller, M. J., Olufsen, M. S., and Hill, N. A. |
| College/School: | College of Science and Engineering > School of Mathematics and Statistics > Mathematics |
| Journal Name: | Computers in Biology and Medicine |
| Publisher: | Elsevier |
| ISSN: | 0010-4825 |
| ISSN (Online): | 1879-0534 |
| Published Online: | 11 August 2025 |
| Copyright Holders: | Copyright © 2025 The Authors |
| First Published: | First published in Computers in Biology and Medicine 196(Part C): 110868 |
| Publisher Policy: | Reproduced under a Creative Commons license |
University Staff: Request a correction | Enlighten Editors: Update this record
Funder and Project Information
EPSRC Centre for Multiscale soft tissue mechanics with application to heart & cancer
Raymond Ogden
EP/N014642/1
M&S - Mathematics
The SofTMech Statistical Emulation and Translation Hub
Dirk Husmeier
EP/T017899/1
M&S - Statistics
Deposit and Record Details
| ID Code: | 361200 |
|---|---|
| Depositing User: | Mr Matt Mahon |
| Datestamp: | 12 Aug 2025 10:05 |
| Last Modified: | 25 Aug 2025 08:37 |
| Date of acceptance: | 29 July 2025 |
| Date of first online publication: | 11 August 2025 |
| Date Deposited: | 12 August 2025 |
| Data Availability Statement: | Yes |