Src kinase inhibitors: an emerging therapeutic treatment option for prostate cancer (original) (raw)

Edwards, J. ORCID: https://orcid.org/0000-0002-7192-6906(2010) Src kinase inhibitors: an emerging therapeutic treatment option for prostate cancer.Expert Opinion on Investigational Drugs, 19(5), pp. 605-614. (doi: 10.1517/13543781003789388)

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Abstract

Areas covered in this review: Here, current treatment options for advanced prostate cancer, the preclinical rationale behind using Src inhibitors, emerging data from clinical trials of Src inhibitors in prostate cancer, and future therapeutic directions are described. Data published in peer-reviewed journals within the last 20 years or presented at recent European or American Society of Clinical Oncology conferences have been reviewed. What the reader will gain: Readers will gain an insight into the development of therapeutic Src inhibitors, including dasatinib and saracatinib; an understanding of their effects on prostate cancer cells and the bone microenvironment; and emerging clinical data. Take home message: Src is implicated in prostate cancer progression and metastasis, therefore treatment with Src inhibitors warrants further investigation

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