Drivers of antimicrobial resistance in pig production systems of Uganda (original) (raw)

Muwonge, Adrian, Kakooza, Tadeo, Johnson, Paul C.D. ORCID: https://orcid.org/0000-0001-6663-7520, Kisuule, Lawrence, Kimaanga, Michael, Kankya, Clovice, Mark de Clare Bronsvoort, Barend and Lembo, Tiziana ORCID: https://orcid.org/0000-0002-6405-1849(2025) Drivers of antimicrobial resistance in pig production systems of Uganda.Communications Earth and Environment, 6, 517. (doi: 10.1038/s43247-025-02506-8) (PMID:40620460) (PMCID:PMC12221980)

Abstract

Increasing protein demand in low- and middle-income countries may accelerate livestock intensification, antibiotic overuse and antimicrobial resistance (AMR) risk. Here, we examined Uganda’s growing pig sector, tracking 70 farmers and their pigs in semi-intensive and free-range systems for a year. We investigated AMR and AMR gene abundance of 668 Escherichia coli, Klebsiella and DNA isolated from 877 faecal samples using diffusion disc-method and qPCR, respectively. Pigs in semi-intensive systems were 2.2 times more likely to exhibit AMR and had higher ermB levels. AMR in free-range farmers was twice that of pigs but still 1.4 times less likely than in semi-intensive systems. AMR prevalence increased by 0.76% per month. Potential transmission events were more likely on semi-intensive farms (OR = 3.16, 95% CI: 2.1–4.3, P < 0.001), especially when farmers had higher tetQ levels than pigs; the reverse was true for ermB. Intensified urban pig production may elevate AMR risks, underscoring the need for targeted interventions.

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