SUBCUT HF II: rationale and design of a multicentre randomized controlled trial of SUBCUTaneous furosemide to support early discharge in patients admitted to hospital due to Heart Failure (original) (raw)
Campbell, R. T. et al. (2026) SUBCUT HF II: rationale and design of a multicentre randomized controlled trial of SUBCUTaneous furosemide to support early discharge in patients admitted to hospital due to Heart Failure.European Journal of Heart Failure, (doi: 10.1093/ejhf/xuaf018) (Early Online Publication)
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Abstract
Introduction: Heart failure (HF) hospitalizations are frequent and lengthy, and usually involve treatment with intravenous diuretics to relieve congestion. SUBCUT HF II is evaluating the safety and efficacy of an alternative ambulatory care strategy using a novel subcutaneous formulation of furosemide delivered via a wearable pump. Methods :The SUBCUT HF II trial is a multicentre, randomized, active comparator trial involving 20 hospitals in the UK. Eligible participants are patients with HF receiving inpatient treatment with intravenous loop diuretic. Patients are randomized to either early supported discharge, using a novel formulation of subcutaneous furosemide (SQIN-Furosemide) administered by a wearable pump (SQIN-Infusor), or continued inpatient treatment using intravenous furosemide. Results :The primary endpoint is days spent alive and out of hospital at 30 days. As of October 2025, 168 of 170 patients have been randomized. Conclusion: The SUBCUT HF II trial is testing the safety and efficacy of an ambulatory care approach to managing patients presenting to the hospital with HF.
| Item Type: | Articles |
|---|---|
| Additional Information: | This trial is funded by an investigator-initiated grant from SQ Innovation, Inc, including supply of the investigational medicinal product and device. |
| Keywords: | heart failure, ambulatory care, randomized-controlled trial, furosemide. |
| Status: | Early Online Publication |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Lees, Miss Andrea and Gardner, Professor Roy and Martin, Mrs Kirsty and Campbell, Dr Ross and O'Donnell, Mrs Joanne and Cleland, Professor John and McMurray, Professor John and Osmanska, Dr Joanna and Placzek, Ms Anna and Petrie, Professor Mark and McConnachie, Professor Alex and Mowat, Ms Kirstie and Docherty, Dr Kieran |
| Creator Roles: | Campbell, R. T.Conceptualization, Data curation, Formal analysis, Writing – original draft, Writing – review and editingWetherall, K.Formal analysis, Methodology, Writing – review and editingPlaczek, A.Project administration, Writing – review and editingO'Donnell, J.Project administration, Writing – review and editingMowat, K.Writing – review and editing, Data curationMcConnachie, A.Formal analysis, Supervision, Writing – review and editingMcMurray, J. J.V.Conceptualization, Supervision, Writing – review and editingLees, A.Data curation, Writing – review and editingGardner, R.Supervision, Writing – review and editingCleland, J.Writing – review and editingDocherty, K.Methodology, Writing – review and editingOsmanska, J.Data curation, Formal analysis, Validation, Writing – review and editingPetrie, M. C.Conceptualization, Funding acquisition, Methodology, Writing – review and editing |
| Authors: | Campbell, R. T., Osmanska, J., Docherty, K. F., Ahmed, F. Z., Clark, A. L., Clayton, L., Cleland, J. G.F., Critoph, C., Dewhurst, M., Hartshorne-Evans, N., Gardner, R. S., Gatenby, K. V., Guha, K., Kalra, P. R., Lees, A., McConnachie, A., Muntendam, P., Mowat, K., O'Donnell, J., Placzek, A., Ray, R., Savage, H. O., Schiff, R., Squire, I., Wetherall, K., Wong, K., Wong, C., McMurray, J. J.V., and Petrie, M. C. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic HealthCollege of Medical Veterinary and Life Sciences > School of Health & Wellbeing > Robertson Centre |
| Journal Name: | European Journal of Heart Failure |
| Publisher: | Oxford University Press |
| ISSN: | 1388-9842 |
| ISSN (Online): | 1879-0844 |
| Published Online: | 12 January 2026 |
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Deposit and Record Details
| ID Code: | 378942 |
|---|---|
| Depositing User: | Ms Kirsten Diamond |
| Datestamp: | 05 Feb 2026 16:02 |
| Last Modified: | 11 Feb 2026 10:09 |
| Date of acceptance: | 10 November 2025 |
| Date of first online publication: | 12 January 2026 |
| Data Availability Statement: | Yes |