Incorporation of N-heterocyclic cations into proteins with a highly directed chemical modification (original) (raw)
McMillan, N., Smith, L.V., de la Fuente, J.M., Parenty, A.D.C., Gadegaard, N. 
ORCID: https://orcid.org/0000-0002-3396-846X, Pitt, A.R., Thomson, K., MacKenzie, C., Kelly, S. and Cronin, L. ORCID: https://orcid.org/0000-0001-8035-5757(2007) Incorporation of N-heterocyclic cations into proteins with a highly directed chemical modification.Chemical Communications, 25, pp. 2581-2583. (doi: 10.1039/b702575k)
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Publisher's URL: http://dx.doi.org/10.1039/b702575k
Abstract
N-Heterocyclic cations are incorporated into proteins using 5-(2-bromoethyl)phenanthridinium bromide, which selectively reacts with either cysteine or lysine residues, resulting in ethylphenanthridinium (Phen) or highly stable cyclised dihydro-imidazo-phenanthridinium (DIP) adducts respectively; these modifications have been found to manipulate the observed structure of lysozyme and bovine serum albumin by AFM.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | McMillan, Miss Nicola and Pitt, Dr Andrew and Cronin, Professor Lee and Gadegaard, Professor Nikolaj and Parenty, Mr Alexis |
| Authors: | McMillan, N., Smith, L.V., de la Fuente, J.M., Parenty, A.D.C., Gadegaard, N., Pitt, A.R., Thomson, K., MacKenzie, C., Kelly, S., and Cronin, L. |
| Subjects: | Q Science > QD Chemistry |
| College/School: | College of Science and Engineering > School of ChemistryUniversity Centres > Glasgow Materials Research Initiative |
| Journal Name: | Chemical Communications |
| ISSN: | 1359-7345 |
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Deposit and Record Details
| ID Code: | 3967 |
|---|---|
| Depositing User: | Users 157 not found. |
| Datestamp: | 28 Feb 2008 |
| Last Modified: | 01 May 2025 13:30 |
| Date of first online publication: | 2007 |