Predicting the conformations of peptides and proteins in early evolution. A review article submitted to Biology Direct (original) (raw)

Milner-White, E.J. and Russell, M.(2008) Predicting the conformations of peptides and proteins in early evolution. A review article submitted to Biology Direct.Biology Direct, 3(3), pp. 1-9. (doi: 10.1186/1745-6150-3-3)

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Publisher's URL: http://dx.doi.org/10.1186/1745-6150-3-3

Abstract

Considering that short, mainly heterochiral, polypeptides with a high glycine content are expected to have played a prominent role in evolution at the earliest stage of life before nucleic acids were available, we review recent knowledge about polypeptide three-dimensional structure to predict the types of conformations they would have adopted. The possible existence of such structures at this time leads to a consideration of their functional significance, and the consequences for the course of evolution.

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