Nomogram for the decline in serum antimüllerian hormone: a population study of 9,601 infertility patients (original) (raw)

Nelson, S.M. ORCID: https://orcid.org/0000-0002-9099-3047, Messow, M.C. ORCID: https://orcid.org/0000-0003-0082-9946, Wallace, A.M., Fleming, R. and McConnachie, A. ORCID: https://orcid.org/0000-0002-7262-7000(2011) Nomogram for the decline in serum antimüllerian hormone: a population study of 9,601 infertility patients.Fertility and Sterility, 95(2), 736-741.e3. (doi: 10.1016/j.fertnstert.2010.08.022)

Full text not currently available from Enlighten.

Publisher's URL: http://dx.doi.org/10.1016/j.fertnstert.2010.08.022

Abstract

Objective: To define an optimal model for the decline in circulating antimullerian hormone (AMH) with age and develop a validated age-related nomogram. Design: Cohort study with validation of linear, biphasic linear, differential, power, and quadratic equations undertaken in two additional cohorts. Setting: United Kingdom infertility clinics. Patient(s): Training cohort of 4,590 infertile women. Two separate validation cohorts; 4,588 infertile women, and 423 women with confirmed ovulation and normal pelvic ultrasound who have a male partner with severe oligospermia. Intervention(s): Serum AMH measurement. Main Outcome Measure(s): Optimal fit and age-related AMH nomogram. Result(s): The linear model had the largest sum of absolute and squared residuals and provided a less adequate fit than the four nonlinear models. Of these, the R-2 ranged from 19.45% to 19.48% in the training dataset, from 21.30% to 21.36% in the validation dataset, and from 13.29% to 13.75% in the partners of oligospermic males. The parameters of the differential model were difficult to estimate, and the goodness-of-fit of the power model was slightly inferior to the quadratic model. Conclusion(s): Circulating AMH concentrations decline with increasing reproductive age in a manner optimally described by a quadratic equation. This validated age-related AMH nomogram will enable counseling of infertility patients regarding reproductive performance.

University Staff: Request a correction | Enlighten Editors: Update this record

Deposit and Record Details