Ring-closing alkyne metathesis approach toward the synthesis of alkyne mimics of thioether A-, B-, C-, and DE-ring systems of the lantibiotic nisin Z (original) (raw)

Ghalit, N., Poot, A.J., Fürstner, A., Rijkers, D.T.S. and Liskamp, R.M.J. ORCID: https://orcid.org/0000-0001-8897-8975(2005) Ring-closing alkyne metathesis approach toward the synthesis of alkyne mimics of thioether A-, B-, C-, and DE-ring systems of the lantibiotic nisin Z.Organic Letters, 7(14), pp. 2961-2964. (doi: 10.1021/ol0508781)

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Abstract

Ring-closing alkyne metathesis toward the synthesis of the alkyne-brigded A-, B-, C-, and (D)E-ring mimics of the peptide antibiotic nisin Z is described. We have successfully synthesized alkyne-bridged cyclic peptides containing 4−7 amino acid residues in yields ranging from 18 to 82%.

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