Situating the default-mode network along a principal gradient of macroscale cortical organization (original) (raw)
Margulies, Daniel S, Ghosh, Satrajit S, Goulas, Alexandros et al. (9 more authors) (2016)Situating the default-mode network along a principal gradient of macroscale cortical organization. Proceedings of the National Academy of Sciences of the United States of America. pp. 12574-12579. ISSN 1091-6490
Abstract
Understanding how the structure of cognition arises from the topographical organization of the cortex is a primary goal in neuroscience. Previous work has described local functional gradients extending from perceptual and motor regions to cortical areas representing more abstract functions, but an overarching framework for the association between structure and function is still lacking. Here, we show that the principal gradient revealed by the decomposition of connectivity data in humans and the macaque monkey is anchored by, at one end, regions serving primary sensory/motor functions and at the other end, transmodal regions that, in humans, are known as the default-mode network (DMN). These DMN regions exhibit the greatest geodesic distance along the cortical surface-and are precisely equidistant-from primary sensory/motor morphological landmarks. The principal gradient also provides an organizing spatial framework for multiple large-scale networks and characterizes a spectrum from unimodal to heteromodal activity in a functional metaanalysis. Together, these observations provide a characterization of the topographical organization of cortex and indicate that the role of the DMN in cognition might arise from its position at one extreme of a hierarchy, allowing it to process transmodal information that is unrelated to immediate sensory input.
Metadata
| Item Type: | Article |
|---|---|
| Authors/Creators: | Margulies, Daniel SGhosh, Satrajit SGoulas, AlexandrosFalkiewicz, MarcelHuntenburg, Julia MLangs, GeorgBezgin, GlebEickhoff, Simon BCastellanos, F XavierPetrides, MichaelJefferies, Elizabeth  https://orcid.org/0000-0002-3826-4330Smallwood, Jonathan https://orcid.org/0000-0002-7298-2459 |
| Copyright, Publisher and Additional Information: | © 2016 National Academy of Sciences. This is an author-produced version of the published paper. Uploaded in accordance with the publisher’s self-archiving policy. Further copying may not be permitted; contact the publisher for details. |
| Dates: | Accepted: 9 September 2016Published (online): 18 October 2016Published: 1 November 2016 |
| Institution: | The University of York |
| Academic Units: | The University of York > Faculty of Sciences (York) > Psychology (York) |
| Depositing User: | Pure (York) |
| Date Deposited: | 18 Nov 2016 11:56 |
| Last Modified: | 16 Oct 2024 13:23 |
| Published Version: | https://doi.org/10.1073/pnas.1608282113 |
| Status: | Published |
| Refereed: | Yes |
| Identification Number: | https://doi.org/10.1073/pnas.1608282113 |