E-cadherin as a prognostic indicator in primary breast cancer (original) (raw)
Parker, C orcid.org/0000-0002-3826-2554, Rampaul, RS, Pinder, SE et al. (6 more authors) (2001)E-cadherin as a prognostic indicator in primary breast cancer. British Journal of Cancer, 85 (12). pp. 1958-1963. ISSN: 0007-0920
Abstract
Epithelial cadherin (E-CD) is a member of the cadherin family of cell adhesion molecules and has been implicated as an invasion suppressor molecule in vitro and in vivo. We analysed 174 breast tumours from the Nottingham/Tenovus Breast Cancer Series immunohistochemically for E-CD expression using the mouse monoclonal antibody HECD-1 (Zymed Laboratories Inc.). In normal epithelial cells E-CD was strongly expressed at cell–cell boundaries. 66% of the breast cancers examined had reduced intensity of E-CD expression with 74% having significant reductions in the proportion of E-CD-positive tumour cells. Using a combined intensity/proportion score, significant associations were found between E-CD expression and tumour type (P ≤ 0.001). ER status (P = 0.026) and histological grade (P = 0.031). Expression of E-CD was not found to be related to recurrence, distant metastases, lymph node stage, vascular invasion, primary tumour size, prognostic group or survival. Thus E-CD expression in human breast cancer appears to have minimal prognostic value, but may have a role as a phenotypic marker.
Metadata
| Item Type: | Article |
|---|---|
| Authors/Creators: | Parker, C  https://orcid.org/0000-0002-3826-2554Rampaul, RSPinder, SEBell, JAWencyk, PMBlamey, RWNicholson, RIRobertson, JFREllis, IO |
| Copyright, Publisher and Additional Information: | © 2001 Cancer Research Campaign. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 Unported (CC BY-NC-SA 3.0) |
| Keywords: | Breast cancer; immunohistochemistry; cadherin; prognosis |
| Dates: | Accepted: 20 September 2001Published (online): 11 December 2001Published: 14 December 2001 |
| Institution: | The University of Leeds |
| Date Deposited: | 24 Sep 2021 15:14 |
| Last Modified: | 24 Sep 2021 15:14 |
| Status: | Published |
| Publisher: | Springer Nature |
| Identification Number: | 10.1054/bjoc.2001.2178 |
| Related URLs: | Author |
| Open Archives Initiative ID (OAI ID): | oai:eprints.whiterose.ac.uk:178362 |