Mehmet Doganay | Erciyes University (original) (raw)
Papers by Mehmet Doganay
Erciyes tıp dergisi, 2006
Frontiers in Immunology, Nov 10, 2022
Mikrobiyoloji Bulteni, 2011
İstanbul Kuzey Klinikleri, 2019
bioRxiv (Cold Spring Harbor Laboratory), Jun 27, 2022
İstanbul Kuzey Klinikleri, 2020
Fems Immunology and Medical Microbiology, Jul 1, 2011
PubMed Central, Sep 1, 2012
Turkish Journal of Medical Sciences, Dec 17, 2021
Recent Patents on Anti-infective Drug Discovery, Oct 2, 2017
Türkiye parazitoloji dergisi, 2018
Zoonotic infections are globally important diseases and lead to huge economic losses in both low-... more Zoonotic infections are globally important diseases and lead to huge economic losses in both low-and middle-income and high-income countries. Global warming, environmental and ecological changes, illegal movement of animals and humans, regional civil wars, and poverty are predisposing factors for the emergence of zoonotic infections and their distribution worldwide; they are also a big threat for the future. In addition, environmental pollution and antimicrobial resistance are immense serious threats and dangers to prevent and control zoonotic infections. The natural location of Turkey allows many emerged or re-emerged infections with zoonotic characteristics by animal movements, such as bird immigrations, and by human movements due to civil wars as seen with regional refugees. Numerous zoonotic diseases, including 37 bacterial, 13 fungal, 29 viral, 28 parasitic (3 trematodes, 7 cestodes, 10 nematodes, and 8 protozoan), and totally 107 infections, have been reported from Turkey to date. Additionally, many ectoparasitic zoonoses within 15 different arthropod groups and one leech infestation have been reported from Turkey to date. The "One Health" initiative is particularly relevant for developing strategies to combat zoonotic diseases. In this article, we review the occurrence of zoonotic diseases in man and animals in Turkey in the light of the "One Health" perspective.
Archives of Pediatric Infectious Diseases, Feb 16, 2021
Context: Sepsis's primary therapy consists of antibiotics therapy, supportive therapies, and sour... more Context: Sepsis's primary therapy consists of antibiotics therapy, supportive therapies, and source control of infection. The failure rate of this approach is about 20-40%. The widespread use of antibiotics has caused multiple drug resistance in primary etiological agents of sepsis in community-acquired and healthcare-associated infections. In the absence of new antibiotic options, alternative treatment modalities seem necessary. Evidence Acquisition: Herein, we have reviewed and discussed current problems with sepsis management and stem cell therapy in sepsis, preclinical, experimental studies, and early-phase clinical trials using stem cells to treat sepsis. In the preparation of the paper, PubMed, Web of Science Core Collection (Clarivate), Scopus, and the web address (www.clinicaltrials.gov) were searched by the keywords (sepsis and cell therapy, septic shock, and cell therapy). Results: After the inclusion of criteria, we reviewed 301 original articles. Few articles were found for phase II and phase III clinical trials. Eighty-three articles were included in the current review article. Besides problems with infection source control, the host immune response to the infection enumerated for primary underlying pathophysiologic dysregulation of sepsis and complicated the treatment. Mesenchymal stem cells (MSCs) therapy offers a promising treatment option for sepsis. Indeed, immunomodulatory properties, antimicrobial activity, the capacity of protection against organ failure, enhance the resolution of tissue injury, tissue repair, and restoration after sepsis confer MSCs with a significant advantage to treat the immune and inflammatory dysfunctions associated with severe sepsis and septic shock. Conclusions: It seems that MSCs therapy exhibits an appropriate safety index. Future trials should focus on strengthening study quality, reporting MSCs' therapeutic effects and adverse events. Although early clinical trials seem promising and have beneficial effects, we need more controlled clinical studies, especially in phases II and III.
BackgroundPreoperative antibiotic prophylaxis is one of the preventive measures for surgical site... more BackgroundPreoperative antibiotic prophylaxis is one of the preventive measures for surgical site infections (SSIs). Very little data about the cost effectiveness of the appropriate duration of antibiotic prophylaxis in low- and middle-income countries are available. We aim to assess the cost effectiveness of the use of antibiotic prophylaxis for <24 hours to prevent neurosurgical infections in a middle-income country, Turkey.MethodsA 1-year prospective study was performed between June 2012 and June 2013. During this study period patients were followed-up on for the development of SSI by means of hospital and postdischarge surveillance. Patients included in the study group received appropriate duration of antibiotic prophylaxis (<24 hours), and the duration of prophylaxis was longer in the control group. The antibiotic costs per patient, including prophylaxis and treatment, were calculated.ResultsA total of 822 operations consisting of craniotomy (n = 558), spinal fusion (n = 220), and ventricular shunt (n = 44) were included in the study. The study group included 488 (59.4%) patients who underwent operations with appropriate duration (<24 hours) of antibiotic prophylaxis. Prophylactic antibiotic cost per patient was significantly lower in the study group ($3.35 and $20.41, respectively). The SSI rates did not differ between the 2 groups: 3.5% (17/488) in the study group and 3.6 (12/822) in the control group (P > .05).ConclusionThis cost-analysis study demonstrates that prolonged antibiotic prophylaxis correlates with increased burden of cost, but it is not preventive for SSI.</p
Turkish Journal of Parasitology, 2020
Vector-borne zoonotic diseases (VBZDs) are a major problem for public health and animal welfare a... more Vector-borne zoonotic diseases (VBZDs) are a major problem for public health and animal welfare all over the world. In recent years, there has been an alarming increase in VBZDs, mainly caused by new or re-emerging arboviruses, bacteria and parasites. The World Health Organization enumerated 10 threats to global health for 2019, notably emphasizing climate change and emerging pathogens as growing priorities. It is important to review potential threats and develop new control programs for rising threats against human health and safety. Changes in host and vector population diversity and density may affect pathogen transmission patterns and influence VBZD emergence processes. In addition to environmental and climate-related changes, human and animal migratory patterns pose future threats. The geographic location and habitat features of Turkey support the establishment of many arthropod species as vectors of various diseases. To date, a total of 107 zoonotic infections have been reported originating from Turkey. Arthropods transmit 19 of 107 such infections, including 2 mosquito-borne, 9 tick-borne, 1 sandfly-borne, 3 flea-borne, 1 simuliid-borne, 1 mite-borne and 2 fly-borne diseases. In this review, we focus on the present status of knowledge on VBZDs as a rising threat to public health in Turkey to provide a foundation for future control efforts.
Turkish Bulletin of Hygiene and Experimental Biology, 2015
In recent years, pets have started to be more commonly in family life, in our country and also al... more In recent years, pets have started to be more commonly in family life, in our country and also all over the world. Previously, animals such as cats, dogs, birds have been ownered more frequently, but today pet range increased remarkably and the animals like hamsters, mice, rats, snakes, lizards, alligators have
Burns, 2009
Risk factors for acquisition of methicillin-resistant Staphylococcus aureus and clonal spread of ... more Risk factors for acquisition of methicillin-resistant Staphylococcus aureus and clonal spread of the isolates in a medical intensive care unit* Aim: Methicillin-resistant Staphylococcus aureus (MRSA) is still the commonest pathogen in hospital-acquired infections with high morbidity and mortality. MRSA colonization usually precedes infection and dissemination of the microorganism. The aim of this study was to determine risk factors for the colonization and infection with MRSA in a medical intensive care unit (MICU) and to show the genetic relation of strains. Materials and methods: This study was conducted prospectively between 1 December 2004 and 31 January 2006 in MICU. Patients (>16 years) admitted to the MICU were screened for MRSA on admission (in the first 48 hours), at the end of the first week, and at the ICU discharge using anterior nares, axilla, and groin swabs. Risk factors for colonization and infection of MRSA were evaluated. Strains isolated from colonized patients were evaluated for genetic relation. Results: During the study period, 259 patients were evaluated for the risk factors of MRSA acquisition. The colonization rate was 18.5%, and 64.6% of the patients were colonized in the first week. In multiple logistic regression analysis, only the length of stay in MICU and mechanical ventilation were significant risk factors for colonization. MRSA infection occurred in 15 (31%) of 48 colonized patients during MICU stay. MRSA colonization and tracheostomy were significant risk factors for MRSA infection. A genetic relation was found in 48 isolates from colonized patients in MICU and 23 isolates from colonized patients on admission. Overall, 4 clones (clone A, B, C, and D) were determined from colonized patients on admission; clone A (37%), clone B (32%), clone C (21%), and clone D (10%). Moreover, patients colonized during MICU stay had similar clones (clone A-30%, clone B-57%, and clone C-13%) with these patients. Conclusion: This study shows a high colonization rate and dissemination of MRSA in a developing country with inadequate infrastructure (lack of nurse, lack of isolation rooms, and heavy workload).
Erciyes tıp dergisi, 2006
Frontiers in Immunology, Nov 10, 2022
Mikrobiyoloji Bulteni, 2011
İstanbul Kuzey Klinikleri, 2019
bioRxiv (Cold Spring Harbor Laboratory), Jun 27, 2022
İstanbul Kuzey Klinikleri, 2020
Fems Immunology and Medical Microbiology, Jul 1, 2011
PubMed Central, Sep 1, 2012
Turkish Journal of Medical Sciences, Dec 17, 2021
Recent Patents on Anti-infective Drug Discovery, Oct 2, 2017
Türkiye parazitoloji dergisi, 2018
Zoonotic infections are globally important diseases and lead to huge economic losses in both low-... more Zoonotic infections are globally important diseases and lead to huge economic losses in both low-and middle-income and high-income countries. Global warming, environmental and ecological changes, illegal movement of animals and humans, regional civil wars, and poverty are predisposing factors for the emergence of zoonotic infections and their distribution worldwide; they are also a big threat for the future. In addition, environmental pollution and antimicrobial resistance are immense serious threats and dangers to prevent and control zoonotic infections. The natural location of Turkey allows many emerged or re-emerged infections with zoonotic characteristics by animal movements, such as bird immigrations, and by human movements due to civil wars as seen with regional refugees. Numerous zoonotic diseases, including 37 bacterial, 13 fungal, 29 viral, 28 parasitic (3 trematodes, 7 cestodes, 10 nematodes, and 8 protozoan), and totally 107 infections, have been reported from Turkey to date. Additionally, many ectoparasitic zoonoses within 15 different arthropod groups and one leech infestation have been reported from Turkey to date. The "One Health" initiative is particularly relevant for developing strategies to combat zoonotic diseases. In this article, we review the occurrence of zoonotic diseases in man and animals in Turkey in the light of the "One Health" perspective.
Archives of Pediatric Infectious Diseases, Feb 16, 2021
Context: Sepsis's primary therapy consists of antibiotics therapy, supportive therapies, and sour... more Context: Sepsis's primary therapy consists of antibiotics therapy, supportive therapies, and source control of infection. The failure rate of this approach is about 20-40%. The widespread use of antibiotics has caused multiple drug resistance in primary etiological agents of sepsis in community-acquired and healthcare-associated infections. In the absence of new antibiotic options, alternative treatment modalities seem necessary. Evidence Acquisition: Herein, we have reviewed and discussed current problems with sepsis management and stem cell therapy in sepsis, preclinical, experimental studies, and early-phase clinical trials using stem cells to treat sepsis. In the preparation of the paper, PubMed, Web of Science Core Collection (Clarivate), Scopus, and the web address (www.clinicaltrials.gov) were searched by the keywords (sepsis and cell therapy, septic shock, and cell therapy). Results: After the inclusion of criteria, we reviewed 301 original articles. Few articles were found for phase II and phase III clinical trials. Eighty-three articles were included in the current review article. Besides problems with infection source control, the host immune response to the infection enumerated for primary underlying pathophysiologic dysregulation of sepsis and complicated the treatment. Mesenchymal stem cells (MSCs) therapy offers a promising treatment option for sepsis. Indeed, immunomodulatory properties, antimicrobial activity, the capacity of protection against organ failure, enhance the resolution of tissue injury, tissue repair, and restoration after sepsis confer MSCs with a significant advantage to treat the immune and inflammatory dysfunctions associated with severe sepsis and septic shock. Conclusions: It seems that MSCs therapy exhibits an appropriate safety index. Future trials should focus on strengthening study quality, reporting MSCs' therapeutic effects and adverse events. Although early clinical trials seem promising and have beneficial effects, we need more controlled clinical studies, especially in phases II and III.
BackgroundPreoperative antibiotic prophylaxis is one of the preventive measures for surgical site... more BackgroundPreoperative antibiotic prophylaxis is one of the preventive measures for surgical site infections (SSIs). Very little data about the cost effectiveness of the appropriate duration of antibiotic prophylaxis in low- and middle-income countries are available. We aim to assess the cost effectiveness of the use of antibiotic prophylaxis for <24 hours to prevent neurosurgical infections in a middle-income country, Turkey.MethodsA 1-year prospective study was performed between June 2012 and June 2013. During this study period patients were followed-up on for the development of SSI by means of hospital and postdischarge surveillance. Patients included in the study group received appropriate duration of antibiotic prophylaxis (<24 hours), and the duration of prophylaxis was longer in the control group. The antibiotic costs per patient, including prophylaxis and treatment, were calculated.ResultsA total of 822 operations consisting of craniotomy (n = 558), spinal fusion (n = 220), and ventricular shunt (n = 44) were included in the study. The study group included 488 (59.4%) patients who underwent operations with appropriate duration (<24 hours) of antibiotic prophylaxis. Prophylactic antibiotic cost per patient was significantly lower in the study group ($3.35 and $20.41, respectively). The SSI rates did not differ between the 2 groups: 3.5% (17/488) in the study group and 3.6 (12/822) in the control group (P > .05).ConclusionThis cost-analysis study demonstrates that prolonged antibiotic prophylaxis correlates with increased burden of cost, but it is not preventive for SSI.</p
Turkish Journal of Parasitology, 2020
Vector-borne zoonotic diseases (VBZDs) are a major problem for public health and animal welfare a... more Vector-borne zoonotic diseases (VBZDs) are a major problem for public health and animal welfare all over the world. In recent years, there has been an alarming increase in VBZDs, mainly caused by new or re-emerging arboviruses, bacteria and parasites. The World Health Organization enumerated 10 threats to global health for 2019, notably emphasizing climate change and emerging pathogens as growing priorities. It is important to review potential threats and develop new control programs for rising threats against human health and safety. Changes in host and vector population diversity and density may affect pathogen transmission patterns and influence VBZD emergence processes. In addition to environmental and climate-related changes, human and animal migratory patterns pose future threats. The geographic location and habitat features of Turkey support the establishment of many arthropod species as vectors of various diseases. To date, a total of 107 zoonotic infections have been reported originating from Turkey. Arthropods transmit 19 of 107 such infections, including 2 mosquito-borne, 9 tick-borne, 1 sandfly-borne, 3 flea-borne, 1 simuliid-borne, 1 mite-borne and 2 fly-borne diseases. In this review, we focus on the present status of knowledge on VBZDs as a rising threat to public health in Turkey to provide a foundation for future control efforts.
Turkish Bulletin of Hygiene and Experimental Biology, 2015
In recent years, pets have started to be more commonly in family life, in our country and also al... more In recent years, pets have started to be more commonly in family life, in our country and also all over the world. Previously, animals such as cats, dogs, birds have been ownered more frequently, but today pet range increased remarkably and the animals like hamsters, mice, rats, snakes, lizards, alligators have
Burns, 2009
Risk factors for acquisition of methicillin-resistant Staphylococcus aureus and clonal spread of ... more Risk factors for acquisition of methicillin-resistant Staphylococcus aureus and clonal spread of the isolates in a medical intensive care unit* Aim: Methicillin-resistant Staphylococcus aureus (MRSA) is still the commonest pathogen in hospital-acquired infections with high morbidity and mortality. MRSA colonization usually precedes infection and dissemination of the microorganism. The aim of this study was to determine risk factors for the colonization and infection with MRSA in a medical intensive care unit (MICU) and to show the genetic relation of strains. Materials and methods: This study was conducted prospectively between 1 December 2004 and 31 January 2006 in MICU. Patients (>16 years) admitted to the MICU were screened for MRSA on admission (in the first 48 hours), at the end of the first week, and at the ICU discharge using anterior nares, axilla, and groin swabs. Risk factors for colonization and infection of MRSA were evaluated. Strains isolated from colonized patients were evaluated for genetic relation. Results: During the study period, 259 patients were evaluated for the risk factors of MRSA acquisition. The colonization rate was 18.5%, and 64.6% of the patients were colonized in the first week. In multiple logistic regression analysis, only the length of stay in MICU and mechanical ventilation were significant risk factors for colonization. MRSA infection occurred in 15 (31%) of 48 colonized patients during MICU stay. MRSA colonization and tracheostomy were significant risk factors for MRSA infection. A genetic relation was found in 48 isolates from colonized patients in MICU and 23 isolates from colonized patients on admission. Overall, 4 clones (clone A, B, C, and D) were determined from colonized patients on admission; clone A (37%), clone B (32%), clone C (21%), and clone D (10%). Moreover, patients colonized during MICU stay had similar clones (clone A-30%, clone B-57%, and clone C-13%) with these patients. Conclusion: This study shows a high colonization rate and dissemination of MRSA in a developing country with inadequate infrastructure (lack of nurse, lack of isolation rooms, and heavy workload).