Tapobrata Mitra | Indian Institute of Technology Kharagpur (original) (raw)
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A new class of C 2 -symmetric bis-isochromene derivatives with 3,3 0 -linkage has been synthesize... more A new class of C 2 -symmetric bis-isochromene derivatives with 3,3 0 -linkage has been synthesized from bis-propargyl sulfones. The method involves treatment of the sulfones with triethylamine to form the isochromene derivatives presumably via the intramolecular Michael addition to the intermediate bis-allenic sulfones. Interestingly, the product expected from the Garratt-Braverman pathway was not obtained. The bis-isochromene 7d displayed RNase A inhibition activity, much stronger than the isochromene 8 and bis-isocoumarin 9.
A new class of C 2 -symmetric bis-isochromene derivatives with 3,3 0 -linkage has been synthesize... more A new class of C 2 -symmetric bis-isochromene derivatives with 3,3 0 -linkage has been synthesized from bis-propargyl sulfones. The method involves treatment of the sulfones with triethylamine to form the isochromene derivatives presumably via the intramolecular Michael addition to the intermediate bis-allenic sulfones. Interestingly, the product expected from the Garratt-Braverman pathway was not obtained. The bis-isochromene 7d displayed RNase A inhibition activity, much stronger than the isochromene 8 and bis-isocoumarin 9.