Bhavna Karnani | Swiss Federal Institute of Technology (ETH) (original) (raw)

Bhavna Karnani

Address: Zurich, Zurich, Switzerland

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Papers by Bhavna Karnani

Research paper thumbnail of O50 Efficacy of xyloglucan, pea protein and chia seed powder for patients with constipation-predominant irritable bowel syndrome: a randomised placebo-controlled trial

Oral Presentations, Jun 1, 2024

Research paper thumbnail of An Intestinal Th17 Subset is Associated with Inflammation in Crohn’s Disease and Activated by Adherent-invasive Escherichia coli

Journal of Crohn's and Colitis

IFNγ-producing ex-Th17 cells [‘Th1/17’] were shown to play a key pathogenic role in experimental ... more IFNγ-producing ex-Th17 cells [‘Th1/17’] were shown to play a key pathogenic role in experimental colitis and are abundant in the intestine. Here, we identified and characterised a novel, potentially colitogenic subset of Th17 cells in the intestine of patients with Crohn’s disease [CD]. Human Th17 cells expressing CCR5 [‘pTh17’] co-expressed T-bet and RORC/γt and produced very high levels of IL-17, together with IFN-γ. They had a gene signature of Th17 effector cells and were distinct from established Th1/17 cells. pTh17 cells, but not Th1/17 cells, were associated with intestinal inflammation in CD, and decreased upon successful anti-TNF therapy with infliximab. Conventional CCR5[-]Th17 cells differentiated to pTh17 cells with IL-23 in vitro. Moreover, anti-IL-23 therapy with risankizumab strongly reduced pTh17 cells in the intestine. Importantly, intestinal pTh17 cells were selectively activated by adherent-invasive Escherichia coli [AIEC], but not by a commensal/probiotic E. coli...

Research paper thumbnail of O50 Efficacy of xyloglucan, pea protein and chia seed powder for patients with constipation-predominant irritable bowel syndrome: a randomised placebo-controlled trial

Oral Presentations, Jun 1, 2024

Research paper thumbnail of An Intestinal Th17 Subset is Associated with Inflammation in Crohn’s Disease and Activated by Adherent-invasive Escherichia coli

Journal of Crohn's and Colitis

IFNγ-producing ex-Th17 cells [‘Th1/17’] were shown to play a key pathogenic role in experimental ... more IFNγ-producing ex-Th17 cells [‘Th1/17’] were shown to play a key pathogenic role in experimental colitis and are abundant in the intestine. Here, we identified and characterised a novel, potentially colitogenic subset of Th17 cells in the intestine of patients with Crohn’s disease [CD]. Human Th17 cells expressing CCR5 [‘pTh17’] co-expressed T-bet and RORC/γt and produced very high levels of IL-17, together with IFN-γ. They had a gene signature of Th17 effector cells and were distinct from established Th1/17 cells. pTh17 cells, but not Th1/17 cells, were associated with intestinal inflammation in CD, and decreased upon successful anti-TNF therapy with infliximab. Conventional CCR5[-]Th17 cells differentiated to pTh17 cells with IL-23 in vitro. Moreover, anti-IL-23 therapy with risankizumab strongly reduced pTh17 cells in the intestine. Importantly, intestinal pTh17 cells were selectively activated by adherent-invasive Escherichia coli [AIEC], but not by a commensal/probiotic E. coli...

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