Zdravko Kosjerina | University of Novi Sad, Faculty of Economics Subotica (original) (raw)

Papers by Zdravko Kosjerina

Acta Clinica Belgica, 2016

Background: Despite improvements in clinical practice, pneumonia remains one of the leading cause... more Background: Despite improvements in clinical practice, pneumonia remains one of the leading causes of death worldwide. Pathologic findings from autopsy reports could provide more precise and valid data on characteristics of pneumonia patients. Methods: We retrospectively reviewed autopsy reports of deceased patients admitted to the Institute for Pulmonary Diseases of Vojvodina in Sremska Kamenica, Serbia, between 1994 and 2003. The patients were classified into two groups: group 1 (n = 161) comprised patients in whom pneumonia was the main cause of death, while group 2 (n = 165) consisted of patients in whom pneumonia was confirmed at autopsy but had various different causes of death. Results: From 1776 patients who underwent autopsy 326 (18.3%) were diagnosed with pneumonia. The most common underlying diseases were atherosclerosis (29.4%), chronic obstructive pulmonary disease (COPD) (26.7%), and malignancies (20.2%). Pneumonia was the main cause of death in 161 cases (group 1) while in group 2 major causes of death were heart failure (HF) (26.7%), acute myocardial infarction (AMI) (16.4%), and pulmonary embolism (PE) (10.9%). Multilobar involvement (91% vs.27%), pulmonary effusion (29% vs.14%), and lung abscess (23.6% vs.8.5%) were more frequently found in group 1, compared to group 2. Conclusion: In patients with pneumonia who underwent autopsy most common underlying diseases were atherosclerosis, COPD, and malignancies, while major causes of death were: progression of pneumonia, HF, AMI, and PE.

Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie, 2005

The frequency of preneoplastic lesions of the lung and bronchial mucosa as well as potential geno... more The frequency of preneoplastic lesions of the lung and bronchial mucosa as well as potential genotype alterations in spatial relationship to pulmonary malignancies still need intensive investigations in order to understand the occurrence and manifestation of lung cancer in detail. To investigate the contemporary manifestation of lung cancer precursor lesions, peripheral (non-neoplastic) lung parenchyma and bronchial mucosa of operated lung carcinomas were analyzed at distinct distances (1, 2, 3, and 4 cm) from the tumor boundary for pre-neoplastic lesions--atypical adenomatoid hyperplasia (AAH) and squamous cell dysplasia (SCD), in 150 surgical specimens. Short-term tissue cultures of additional 55 primary and secondary lung tumors and their surrounding non-neoplastic bronchial mucosa were performed at the same distances in order to search for chromosome alterations, i.e. genotype aberrations. In phenotype observations, atypical adenomatoid hyperplasia was noted in 19/150 (13%) case...

European Respiratory Journal, 2016

Estrogens behave as promoters in the process of carcinogenesis, via receptor-mediated mechanisms.... more Estrogens behave as promoters in the process of carcinogenesis, via receptor-mediated mechanisms. ERβ expression is excessively higher in lung cancer than ERα expression. The objectives of this study were to establish the treatment response and survival differences between the sexes of lung adenocarcinoma patients depending on the presence of ERβ in the tumor tissue. The study included 200 patients with diagnosis of lung adenocarcinoma. The hormone receptor9s expression in tumor tissue samples was determined by immunohistochemistry method using the primary monoclonal estrogen receptor (beta) antibody, Clone EMR02, NCL-ER-beta. The disease progression and the treatment response were more frequently registered in ERβ- patients. In the female patients, the disease progression was more frequently registered in ERβ- than in ERβ+ patients. Neither was a statistically significant difference registered in the time passing till the onset of the disease progression in the overall examined population, unlike in the examined females, in whom it was 16.5 and 9.5 months with ERβ+ and ERβ- tumor status respectively making statistically significant difference (p=0.041). The analysis of the cumulative survival depending on the patients9 sex and receptor status (males ERβ-, males ERβ+, females ERβ-, females ERβ+) has revealed that ERβ+ females had a significantly longer survival than other three subgroups (Breslow: p=0.037; Mantel-Cox: p=0.112). The hormonal receptor status is doubtlessly one of many factors in lung cancer carcinogenesis and may be establish as a prognostic factor in lung cancer and potential factor in multi modal (hormonal therapy-anti estrogen) treatment of this malignancy.

Proceedings How to measure image quality in tissue-based diagnosis (diagnostic surgical pathology)

LCH is characterized by the presence of Langerhans cells juxtaposed against a backdrop of hematop... more LCH is characterized by the presence of Langerhans cells juxtaposed against a backdrop of hematopoietic cells, including T-cells, macrophages, and eosinophils. The investigated material included open lung biopsy samples taken from seven patients (four males and three females) at the mean age of 23.2 years. They were all smokers. The intensity of the histological lesions was semiquantitatively measured, differentiating three intensity grades: mild, moderate and intense. In most cases (3/7), the interalveolar septa were focally and intensively thickened. The in? ammatory ino ltrates in the septa were focal, intense in 3/7, moderate in 1/7, and mild in 1/7 specimens. Lymphocytes prevailed, followed by macrophages, eosinophil granulocytes, and plasma cells. The lumen of the alveoli was occupied by a few macrophages and lymphocytes, sparse plasma cells and few eosinophil granulocytes. The

A surface defect is registered in 134 (92%) patients. The presence of fibrin is established in 14... more A surface defect is registered in 134 (92%) patients. The presence of fibrin is established in 141 (97%) patients, registered in the largest quantities within the 2-7 day interval from the former biopsy. Fibrin granulocytes are registered in 126 (86.8%) patients and the micro abscess formation in 4 (2.7%) patients. A mononuclear infiltration is disclosed in 132 (91%) patients. The squamous stratified epithelium is found in all patients, ranging in thickness from 1-6 layers. The squamous epithelium underlying fibrin is found in 4 (2.7%) patients, superimposing it in 124 (85.5%) patients, or within it in 108 (74.48%) patients. The epithelium is registered on the basal membrane in 18 (12%) patients, emerging from the 12th day onwards following the former biopsy sampling. In fact, it is most frequently registered on the 14th day (54% of the patients). A break in the basal membrane is discovered in 106 (73%) patients. Surface cornification is present in 8 (5%) patients and dyskeratosis i...

Clinical Medicine Insights: Pathology

was to review the clinical data, radiological findings, lung histology results, and treatment of ... more was to review the clinical data, radiological findings, lung histology results, and treatment of pulmonary cryptococcosis in patients who presented with lung mass. Materials and Methods Study patients This study protocol was approved by the Ethics Committee of our institution. The subjects of this study were 7 patients who were treated

Central European Journal of Medicine, Feb 1, 2012

Background: The clear cell "sugar" tumor of the lung is an extremely rare benign mesenchymal tumo... more Background: The clear cell "sugar" tumor of the lung is an extremely rare benign mesenchymal tumor. Aim: To report a case of the sugar tumor and discuss diagnostic differentiation of the tumor. Case report: A 53-year female presented with persisting cough. A CT scan revealed a round, 10 mm nodule located within the right lower lobe. The nodule was easily removed during thoracotomy. On the gross examination, the tumor was well circumscribed, and had a homogenous grayish-white appearance on the cut surface. The tumor consisted of round and oval cells with abundant clear cytoplasm, showing PAS pozitive abundant glycogen granules, which were removed by diastase pre-treatment before further staining with PAS. Immunohistochemical studies revealed the tumor cells were positive for HMB-45, vimentin, S-100 protein and very few cells for CD-117. The tumor cells were negative for αSMA, CK-7, AE1/AE3, CD-10, chromogranin and TTF-1. Conclusion: Based on the clinical, pathohistological and immunohistochemical data, the diagnosis of the primary clear cell sugar tumor of the lung was established.

Srpski arhiv za celokupno lekarstvo, 2015

The splenic involvement is common in sarcoidosis, but its real frequency is still obscure dependi... more The splenic involvement is common in sarcoidosis, but its real frequency is still obscure depending doubtless on the method of splenomegaly detection. Splenomegaly may be accompanied with pain or anemia, leucopenia and thrombocytopenia. The aim of this study was to investigate the frequency of splenomegaly related to clinical characteristics of sarcoidosis and to solve the dilemma--whether to introduce medicaments, and when to perform splenectomy. The method of the study is a retrospective and prospective analysis of the patients&amp;amp;amp;#39;material. The study included 540 patients with sarcoidosis in a 20-year period. Of them, 26% had splenomegaly detected by computerized tomography screening. Splenomegaly was more frequently registered in the patients with a longer history of sarcoidosis (38%), as compared to those with a shorter history of the disease (23%) (p &amp;amp;amp;lt; 0.05). Splenomegaly was more frequently registered in the patients with other extrapulmonary lesions detected (33%) than in those who had no extrapulmonary manifestations of sarcoidosis (17%) (p &amp;amp;amp;lt; 0.01). Indications, possible benefits and complications of splenectomy were analysed in 11 sarcoidosis patients undergoing this intervention for various reasons, of which the follow-up period ranged from one to 20 years. Splenomegaly was more frequent in chronic cases or in the patients with established sarcoid lesions of other extrapulmonary organs.The primary treatment of uncomplicated symptomatic splenic sarcoidosis includes medicamentous therapy. Occasionally, splenectomy is required. Prognostically, splenomegaly indicates an unfavorable course of the disease.

Analytical and quantitative cytology and histology / the International Academy of Cytology [and] American Society of Cytology, 2008

To create algorithms and application tools that can support routine diagnoses of various organs. ... more To create algorithms and application tools that can support routine diagnoses of various organs. A generalized algorithm was developed that permits the evaluation of diagnosis-associated image features obtained from hematoxylin-eosin-stained histopathologic slides. The procedure was tested for screening of tumor tissue vs. tumor-free tissue in 1,442 cases of various organs. Tissue samples studied include colon, lung, breast, pleura, stomach and thyroid. The algorithm distinguishes between texture- and object-related parameters. Texture-based information-defined as gray value per pixel measure--is independent from any segmentation procedure. It results in recursive vectors derived from time series analysis and image features obtained by spatial dependent and independent transformations. Object-based features are defined as gray value per biologic object measured. The accuracy of automated crude classification was between 95% and 100% based upon a learning set of 10 cases per diagnosi...

Central European Journal of Medicine, 2013

Pulmonary inflammatory myofibroblastic tumor encompasses a heterogeneous spectrum of reactive, in... more Pulmonary inflammatory myofibroblastic tumor encompasses a heterogeneous spectrum of reactive, infectious, and neoplastic entities. It is composed of spindle-shaped myofibroblastic cells in a background of inflammatory cells and collagen fibres. Actinomycosis is a bacterial infection. It infects the lower respiratory tracts by inhalation or aspiration of oropharyngeal or upper gastrointestinal materials. Only eight cases of pulmonary IMT associated with actinomycosis have been reported in the literature so far. This is the ninth case reported.

Central European Journal of Medicine, 2012

Multidisciplinary Respiratory Medicine, 2011

Background: The major aim of this study was to investigate what patients with advanced stage lung... more Background: The major aim of this study was to investigate what patients with advanced stage lung cancer, enrolled in a clinical trial, thought about their treatment. We also wanted to investigate if there exist any characteristics that could influence patients' opinion about the clinical trial. Patients and methods: Over the period from June 2008 to June 2009, 59 eligible patients were enrolled in this study. The major inclusion criteria were: participation in a clinical trial, previously treated advanced stage lung cancer, and good performance status (ECOG 0-2). All patients were asked to answer a questionnaire designed to investigate their impressions about participation in a clinical trial. The questionnaire was deposited in a sealed box which was opened at the end of the study. We investigated a possible influence of age, gender, education, lung cancer stage, chemotherapy line and tumor type on the patients' opinion about some aspects of the clinical trial. Results: The majority of the patients were aware they were participating in the clinical trial and a significant number of them were very satisfied with the treatment. Of the investigated factors, only the level of education had a statistically significant influence on some of the questions raised in the questionnaire.

Multidisciplinary Respiratory Medicine, 2012

Background: This study aims to analyze the structure and quantities of cellular elements in sarco... more Background: This study aims to analyze the structure and quantities of cellular elements in sarcoid granulomas. Methods: We investigated 34 transbronchial lung biopsy samples obtained from 34 sarcoid patients. The quantity and composition of the cellular elements inside a granuloma were determined by the quantitative stereometry method, employing the numerical density as a stereological method.

Electronic Journal of …, 2002

Introduction Material and Methods Light microscopic morphology of AHH Results Discussion References

Herz, 2013

Austauschplattformen.