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Research paper thumbnail of Feeling physical pain while depressed: The effect of alexithymia

Research paper thumbnail of Robert G. Robinson Effect of Antidepressant Therapy on Executive Function after Stroke

Research paper thumbnail of Recalling Word List Reveals “Cognitive Dysmetria” In Schizophrenic Patients. A PET Study

Research paper thumbnail of Cerebral Reorganization of Function after Brain Damage

Journal of Nervous and Mental Disease, Aug 1, 2002

Research paper thumbnail of Ventromedial Prefrontal Cortex Is Critical for Helping Others Who Are Suffering

Frontiers in Neurology, May 25, 2018

Research paper thumbnail of Affective Neuroscience: The Foundations of Human and Animal Emotions

American Journal of Psychiatry, Oct 1, 2002

Research paper thumbnail of Neuroimaging: A Companion to Adams and Victor's Principles of Neurology

American Journal of Psychiatry, May 1, 1996

Part I: Cardinal Manifestations of Neurologic Disease. Section I: Disorders of Motility. Abnormal... more Part I: Cardinal Manifestations of Neurologic Disease. Section I: Disorders of Motility. Abnormalities of Movement and Posture Due to Disease of the Extrapyramidal Motor Systems. Disorders of Stance and Gait. Section II: Pain, Headache. Neuroimaging of Pain. Neuroimaging of Headache. Section III: Disorders of the Special Senses. Disturbances of Vision, Ocular Movement, and Pupillary Function. Deafness, Dizziness, Disorders of Equilibrium. Section IV: Epilespy and Disorders of Consciousness. Neuroimaging and Epilepsy. Section V: Derangements of Intellect, Behavior, and Language Due to Diffuse and Focal Cerebral Disease. Neuroimaging and Behavioral Neurology. Section VI: Disorders of Mood and Emotion. Imaging in Psychiatric Disorders. Part II: The Neurology of Aging. Neuroimaging of Normal Brain Aging and Dementia. Part III: The Major Categories of Neurologic Disease. Disturbances of Cerebrospinal Fluid Circulation, Including Hyrocephalus and Menengeal Reactions. Intracranial Neoplasms. Viral and Nonviral Infections of the Nervous System. The Acquired Immunodeficiency Syndrome. Neuroimaging in Patients with Cerebrovascular Disease. Diseases of the Spinal Cord. Imaging Multiple Sclerosis. Imaging the Brain Lesions of Alcoholics. Pediatric Neuroimaging. Part IV: Special Section on Specific Imaging Modalities. Diffusion-Perfusion MRI and Magnetic Resonance Spectroscopy in Cerebrovascular Disease. Imaging of Strocke with SPECT. Ultrasound in Cerebrovascular Disease. Magnetic Resonance Angiography. Neurospectroscopy. Interventional Neuroimaging.

Research paper thumbnail of Lifetime Physical Activity and White Matter Hyperintensities in Cognitively-Intact Adults

Research paper thumbnail of Dialogos Entre Teatroy Neurociencias

Research paper thumbnail of The Emotional Brain: The Mysterious Underpinnings of Emotional Life

American Journal of Psychiatry, Apr 1, 1998

... Jorge Armony and Mian Hou assisted with the illustrations. ... 2 SOULS ON ICE Gvs&£) &quo... more ... Jorge Armony and Mian Hou assisted with the illustrations. ... 2 SOULS ON ICE Gvs&£) "Think, think, think." Winnie the Pooh1 "Ahab never thinks, he just feels, feels, feels." Herman Melville, Moby-Dick2 THE HUMAN BRAIN CONTAINS about 10 billion neurons that are wired ...

Research paper thumbnail of Towards a classification of alexithymia: Primary, secondary and organic

Journal of Psychopathology, 2014

Background: Emotion processing is essential for well-being and psychosocial adaptation. Alexithym... more Background: Emotion processing is essential for well-being and psychosocial adaptation. Alexithymia is widely viewed as an impairment in emotion processing that includes difficulty identifying and describing emotions. While there is a significant understanding of primary alexithymia, which is thought to be the result of developmental genetic and familial factors, secondary and organic alexithymia are beginning to be focus of research. Method and results: The present review of the literature suggests the importance of differentiating between primary and secondary alexithymia, and the organic subtype of secondary alexithymia. Secondary alexithymia is thought to be a consequence of psychological stress, chronic disease, or organic processes (e.g. brain trauma or stroke) that occur after childhood (whereas primary alexithymia is a developmental phenomenon). Organic insults to the brain may bring about the organic form of alexithymia by altering cerebral structures involved in emotional processing (e.g. anterior cingulate cortex, frontostriatal networks, callosum corpus, right hemisphere cortex and amygdala). The usefulness of differentiating among alexithymia categories and their relationships with brain structures known to subserve emotional processing is discussed. Conclusion: We propose that differentiating between primary, secondary and organic alexithymia may potentially serve to develop better treatments for alexithymia.

Research paper thumbnail of An Initial Study of Alexithymia and Its Relationship With Cognitive Abilities Among Mild Cognitive Impairment, Mild Alzheimer's Disease, and Healthy Volunteers

The Journal of nervous and mental disease, 2018

The present study examined the degree to which alexithymia is greater in mild Alzheimer's dis... more The present study examined the degree to which alexithymia is greater in mild Alzheimer's disease (AD) and mild cognitive impairment (MCI) relative to healthy volunteers (healthy comparison [HC]), and investigated relationships between alexithymia and cognition. Eighty-five participants (MCI = 30, AD = 21, HC = 34) underwent a comprehensive neuropsychological examination and completed the 20-item Toronto Alexithymia Scale (TAS-20). Relative to HC, MCI and AD reported greater alexithymia total scores and higher scores on the TAS factor difficulty in identifying feelings (DIF). The remaining two factors, difficulty in describing feelings (DDF) and externally oriented thinking showed no significant group differences. In MCI, TAS-20 and DIF were negatively correlated with working and long-term verbal memory. In AD, TAS-20 was negatively correlated with general cognition, attention, memory, and visual spatial constructive and executive abilities. Also in AD, DIF was negatively correl...

Research paper thumbnail of Diet and Nutrition in Dementia and Cognitive Decline

Journal of Nutrition Education and Behavior, 2015

Research paper thumbnail of Emotions activate limbic circuitry in elderly normals using PET

Research paper thumbnail of Aging and alexithymia: association with reduced right rostral cingulate volume

The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry, 2008

Previous studies have linked alexithymia to an inability to process emotions appropriately. Older... more Previous studies have linked alexithymia to an inability to process emotions appropriately. Older persons show changes in emotion processing and have higher alexithymia scores. Because the anterior cingulate cortex (ACC) is one of the regions showing earlier decline in late-life, and alexithymia seems to be related to a dysfunction in right hemisphere regions including the ACC subserving affective processes, the present study sought to test the hypothesis that reduced ACC volume accounts for the association between older age and alexithymia. Correlation analyses between functionally distinct ACC subregions, age and alexithymia features. University of Iowa. Twenty-four healthy volunteers aged between 24 and 79 years. Psychiatric and neuropsychological assessment and assessment of alexithymia using the 20-item Toronto Alexithymia Scale. High-resolution magnetic resonance imaging, and in-house developed methods for ACC parcellation. Older age directly correlated with higher overall ale...

Research paper thumbnail of The cerebellum and emotional experience

Research paper thumbnail of Neglect After Right Insular Cortex Infarction

Stroke, 1999

Background and Purpose —Case reports have shown an association between right insular damage and n... more Background and Purpose —Case reports have shown an association between right insular damage and neglect. The aim of this study was to examine the incidence of neglect among patient groups with right or left insular infarction. Methods —We examined neglect in 9 right-handed subjects with insular stroke as evidenced by CT and/or MRI scans (4 with right insular and 5 with left insular cerebrovascular accident) between 4 and 8 weeks after acute stroke with tests of visual, tactile, and auditory perception. Results —Compared with patients with left insular lesions, patients with right insular lesions showed significant neglect in the tactile, auditory, and visual modalities. Conclusions —The right insular cortex seems to have a role in awareness of external stimuli, and infarction in this area may lead to neglect in multisensory modalities.

Research paper thumbnail of Perception of socially relevant stimuli in schizophrenia

Schizophrenia Research, 2006

Research paper thumbnail of Neural bases of dysphoria in early Huntington's disease

Psychiatry Research: Neuroimaging, 2008

Research paper thumbnail of Cognitive and neurological impairment in mood disorders

Psychiatric Clinics of North America, 2004

Research paper thumbnail of Feeling physical pain while depressed: The effect of alexithymia

Research paper thumbnail of Robert G. Robinson Effect of Antidepressant Therapy on Executive Function after Stroke

Research paper thumbnail of Recalling Word List Reveals “Cognitive Dysmetria” In Schizophrenic Patients. A PET Study

Research paper thumbnail of Cerebral Reorganization of Function after Brain Damage

Journal of Nervous and Mental Disease, Aug 1, 2002

Research paper thumbnail of Ventromedial Prefrontal Cortex Is Critical for Helping Others Who Are Suffering

Frontiers in Neurology, May 25, 2018

Research paper thumbnail of Affective Neuroscience: The Foundations of Human and Animal Emotions

American Journal of Psychiatry, Oct 1, 2002

Research paper thumbnail of Neuroimaging: A Companion to Adams and Victor's Principles of Neurology

American Journal of Psychiatry, May 1, 1996

Part I: Cardinal Manifestations of Neurologic Disease. Section I: Disorders of Motility. Abnormal... more Part I: Cardinal Manifestations of Neurologic Disease. Section I: Disorders of Motility. Abnormalities of Movement and Posture Due to Disease of the Extrapyramidal Motor Systems. Disorders of Stance and Gait. Section II: Pain, Headache. Neuroimaging of Pain. Neuroimaging of Headache. Section III: Disorders of the Special Senses. Disturbances of Vision, Ocular Movement, and Pupillary Function. Deafness, Dizziness, Disorders of Equilibrium. Section IV: Epilespy and Disorders of Consciousness. Neuroimaging and Epilepsy. Section V: Derangements of Intellect, Behavior, and Language Due to Diffuse and Focal Cerebral Disease. Neuroimaging and Behavioral Neurology. Section VI: Disorders of Mood and Emotion. Imaging in Psychiatric Disorders. Part II: The Neurology of Aging. Neuroimaging of Normal Brain Aging and Dementia. Part III: The Major Categories of Neurologic Disease. Disturbances of Cerebrospinal Fluid Circulation, Including Hyrocephalus and Menengeal Reactions. Intracranial Neoplasms. Viral and Nonviral Infections of the Nervous System. The Acquired Immunodeficiency Syndrome. Neuroimaging in Patients with Cerebrovascular Disease. Diseases of the Spinal Cord. Imaging Multiple Sclerosis. Imaging the Brain Lesions of Alcoholics. Pediatric Neuroimaging. Part IV: Special Section on Specific Imaging Modalities. Diffusion-Perfusion MRI and Magnetic Resonance Spectroscopy in Cerebrovascular Disease. Imaging of Strocke with SPECT. Ultrasound in Cerebrovascular Disease. Magnetic Resonance Angiography. Neurospectroscopy. Interventional Neuroimaging.

Research paper thumbnail of Lifetime Physical Activity and White Matter Hyperintensities in Cognitively-Intact Adults

Research paper thumbnail of Dialogos Entre Teatroy Neurociencias

Research paper thumbnail of The Emotional Brain: The Mysterious Underpinnings of Emotional Life

American Journal of Psychiatry, Apr 1, 1998

... Jorge Armony and Mian Hou assisted with the illustrations. ... 2 SOULS ON ICE Gvs&£) &quo... more ... Jorge Armony and Mian Hou assisted with the illustrations. ... 2 SOULS ON ICE Gvs&£) "Think, think, think." Winnie the Pooh1 "Ahab never thinks, he just feels, feels, feels." Herman Melville, Moby-Dick2 THE HUMAN BRAIN CONTAINS about 10 billion neurons that are wired ...

Research paper thumbnail of Towards a classification of alexithymia: Primary, secondary and organic

Journal of Psychopathology, 2014

Background: Emotion processing is essential for well-being and psychosocial adaptation. Alexithym... more Background: Emotion processing is essential for well-being and psychosocial adaptation. Alexithymia is widely viewed as an impairment in emotion processing that includes difficulty identifying and describing emotions. While there is a significant understanding of primary alexithymia, which is thought to be the result of developmental genetic and familial factors, secondary and organic alexithymia are beginning to be focus of research. Method and results: The present review of the literature suggests the importance of differentiating between primary and secondary alexithymia, and the organic subtype of secondary alexithymia. Secondary alexithymia is thought to be a consequence of psychological stress, chronic disease, or organic processes (e.g. brain trauma or stroke) that occur after childhood (whereas primary alexithymia is a developmental phenomenon). Organic insults to the brain may bring about the organic form of alexithymia by altering cerebral structures involved in emotional processing (e.g. anterior cingulate cortex, frontostriatal networks, callosum corpus, right hemisphere cortex and amygdala). The usefulness of differentiating among alexithymia categories and their relationships with brain structures known to subserve emotional processing is discussed. Conclusion: We propose that differentiating between primary, secondary and organic alexithymia may potentially serve to develop better treatments for alexithymia.

Research paper thumbnail of An Initial Study of Alexithymia and Its Relationship With Cognitive Abilities Among Mild Cognitive Impairment, Mild Alzheimer's Disease, and Healthy Volunteers

The Journal of nervous and mental disease, 2018

The present study examined the degree to which alexithymia is greater in mild Alzheimer's dis... more The present study examined the degree to which alexithymia is greater in mild Alzheimer's disease (AD) and mild cognitive impairment (MCI) relative to healthy volunteers (healthy comparison [HC]), and investigated relationships between alexithymia and cognition. Eighty-five participants (MCI = 30, AD = 21, HC = 34) underwent a comprehensive neuropsychological examination and completed the 20-item Toronto Alexithymia Scale (TAS-20). Relative to HC, MCI and AD reported greater alexithymia total scores and higher scores on the TAS factor difficulty in identifying feelings (DIF). The remaining two factors, difficulty in describing feelings (DDF) and externally oriented thinking showed no significant group differences. In MCI, TAS-20 and DIF were negatively correlated with working and long-term verbal memory. In AD, TAS-20 was negatively correlated with general cognition, attention, memory, and visual spatial constructive and executive abilities. Also in AD, DIF was negatively correl...

Research paper thumbnail of Diet and Nutrition in Dementia and Cognitive Decline

Journal of Nutrition Education and Behavior, 2015

Research paper thumbnail of Emotions activate limbic circuitry in elderly normals using PET

Research paper thumbnail of Aging and alexithymia: association with reduced right rostral cingulate volume

The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry, 2008

Previous studies have linked alexithymia to an inability to process emotions appropriately. Older... more Previous studies have linked alexithymia to an inability to process emotions appropriately. Older persons show changes in emotion processing and have higher alexithymia scores. Because the anterior cingulate cortex (ACC) is one of the regions showing earlier decline in late-life, and alexithymia seems to be related to a dysfunction in right hemisphere regions including the ACC subserving affective processes, the present study sought to test the hypothesis that reduced ACC volume accounts for the association between older age and alexithymia. Correlation analyses between functionally distinct ACC subregions, age and alexithymia features. University of Iowa. Twenty-four healthy volunteers aged between 24 and 79 years. Psychiatric and neuropsychological assessment and assessment of alexithymia using the 20-item Toronto Alexithymia Scale. High-resolution magnetic resonance imaging, and in-house developed methods for ACC parcellation. Older age directly correlated with higher overall ale...

Research paper thumbnail of The cerebellum and emotional experience

Research paper thumbnail of Neglect After Right Insular Cortex Infarction

Stroke, 1999

Background and Purpose —Case reports have shown an association between right insular damage and n... more Background and Purpose —Case reports have shown an association between right insular damage and neglect. The aim of this study was to examine the incidence of neglect among patient groups with right or left insular infarction. Methods —We examined neglect in 9 right-handed subjects with insular stroke as evidenced by CT and/or MRI scans (4 with right insular and 5 with left insular cerebrovascular accident) between 4 and 8 weeks after acute stroke with tests of visual, tactile, and auditory perception. Results —Compared with patients with left insular lesions, patients with right insular lesions showed significant neglect in the tactile, auditory, and visual modalities. Conclusions —The right insular cortex seems to have a role in awareness of external stimuli, and infarction in this area may lead to neglect in multisensory modalities.

Research paper thumbnail of Perception of socially relevant stimuli in schizophrenia

Schizophrenia Research, 2006

Research paper thumbnail of Neural bases of dysphoria in early Huntington's disease

Psychiatry Research: Neuroimaging, 2008

Research paper thumbnail of Cognitive and neurological impairment in mood disorders

Psychiatric Clinics of North America, 2004