Michel Fromm | Université de Franche-Comté (original) (raw)
I was born in Colmar, France in 1962. I received the Ph.D. degree in 1990 from the Université de Franche-Comté, France. After a three year position as Research Engineer in Electron Microscopy at the Faculty of Pharmacy and Medecine of Besançon I held an Assistant Professor position in Physical Chemistry at the University of Franche-Comté in 1993. In 2002, I was designated Director of the Laboratoire de Microanalyses Nucleaires-Alain Chambaudet of the same university. In 2003, I became Professor at the Université de Franche-Comté in Physical Chemistry and in the same year the laboratory became a Mix Unit of the French Atomic Agency (CEA). Today, this unit is integrated in the mixt unit of the French National Center for Scientific Research (CNRS)
less
Uploads
Papers by Michel Fromm
Physica Scripta
Annular-dose AD is a new conception , based on the radial dose distribution, RDD, introduced by t... more Annular-dose AD is a new conception , based on the radial dose distribution, RDD, introduced by the present work. AD is the integrated dose for many shells around the ions and it is defined as the dose deposited in the shell volume perpendicular to the ion path of width ( r = 0.1 → R min ) , length equal 2 π and thickness equal unity (1 nm). Thus, it integrates and maps the deposited dose due to ion in any medium at nanometer scale better than the ordinary radial dose. Katz and Awad radial dose formulae plus Butts-Katz and Tabata electron range-energy relations are composing three different approaches. These approaches were used for studying the AD for 30 ions forming 4 different equal LET groups and have energy at Bragg peak region from 1.5 to 24 MeV n−1. The annular dose, AD as a function of the shell width for the ions under investigation showed that dose distributions around the ions of same LET are not the same and a clear peak at certain shell width called the ion’s maximum an...
Colloids and Surfaces B: Biointerfaces, 2018
Materials Science and Engineering: C, 2017
EPJ Web of Conferences, 2016
Radiation Physics and Chemistry, 2016
Physica medica : PM : an international journal devoted to the applications of physics to medicine and biology : official journal of the Italian Association of Biomedical Physics (AIFB), 2001
Unanticipated late effects in neutron and heavy ion therapy, not attributable to overdose, imply ... more Unanticipated late effects in neutron and heavy ion therapy, not attributable to overdose, imply a qualitative difference between low and high LET therapy. We identify that difference as 'ion kill', associated with the spectrum of z/beta in the radiation field, whose measurement we label 'ion-kill dosimetry'.
Radiation Physics and Chemistry, 2021
Radiation Measurements, 2001
Polymer Degradation and Stability, 2019
Abstract This review paper intends at identifying the early processes arising during the formatio... more Abstract This review paper intends at identifying the early processes arising during the formation of a latent ion track in Poly Allyl Diglycol Carbonate (PADC). We briefly summarize the physical and chemical processes specific to the description of the interaction of ionizing radiation with matter. Then we gather published information in relation to PADC response regarding energy absorption and further transient species formation. Emphasis is given to the chemistry of radicals. Due to a lack of available data in relation with clearly identified unpaired electron carriers in PADC, we use data stemming from surrogate molecules. Based on such data we suggest mechanisms for the decomposition of PADC during the early times of ion track formation. The α-sites of ether functional groups in PADC appear undoubtedly as critical targets which during further decomposition behave as the most probable origin of Carbon dioxide release. All suggested mechanisms are multi-step processes. Combining different concepts and data in relation with the dynamics of transient species formed in the ion track of a polymer material, we propose that the effective track radius may be described as the radial extension of reactive species formed rather than the maximum distance at which δ-rays escape out of ion's trajectory. Lastly, generalization of the different processes collected allows two major pathways to be proposed for describing the fate of damaged ether moieties in PADC. This way, evidence is given for a higher sensitivity of ether functional groups compared to ester carbonate ones. The latter generally being destroyed as a consequence of prior damaging of the ether group. Discussion presented here is of interest to the nuclear track community.
The Journal of Physical Chemistry C
Journal of photochemistry and photobiology. B, Biology, 2018
The oxidation of proteins results in their deterioration via the oxidation of reactive amino acid... more The oxidation of proteins results in their deterioration via the oxidation of reactive amino acids. Oxidation of the amino acid, methionine plays an important role during biological conditions of oxidative stress, and equally a role in protein stability. In this study the oxidation of the methionine residue using the tripeptide GlyMetGly with respect to hydrogen peroxide has been studied using both Raman spectroscopy and DFT calculations. Spectral modifications following the formation of methionine sulfoxide are shown with the appearance of the SO vibration whilst there is also the modification of the CS vibrations at approximately 700 cm. The changes in the intensity of the CS stretching band were used to calculate the kinetic rate constant as 7.9 ± 0.6 × 10 dm mol s. The energy barrier for the reaction. is determined both experimentally and using DFT calculations. The reaction of the dairy protein beta-lactoglobulin with hydrogen peroxide is equally studied using the same techniqu...
Radiation Research, Jun 1, 2009
Radiation Measurements, Aug 1, 2008
Surface Science, Jan 7, 2013
Physica Scripta
Annular-dose AD is a new conception , based on the radial dose distribution, RDD, introduced by t... more Annular-dose AD is a new conception , based on the radial dose distribution, RDD, introduced by the present work. AD is the integrated dose for many shells around the ions and it is defined as the dose deposited in the shell volume perpendicular to the ion path of width ( r = 0.1 → R min ) , length equal 2 π and thickness equal unity (1 nm). Thus, it integrates and maps the deposited dose due to ion in any medium at nanometer scale better than the ordinary radial dose. Katz and Awad radial dose formulae plus Butts-Katz and Tabata electron range-energy relations are composing three different approaches. These approaches were used for studying the AD for 30 ions forming 4 different equal LET groups and have energy at Bragg peak region from 1.5 to 24 MeV n−1. The annular dose, AD as a function of the shell width for the ions under investigation showed that dose distributions around the ions of same LET are not the same and a clear peak at certain shell width called the ion’s maximum an...
Colloids and Surfaces B: Biointerfaces, 2018
Materials Science and Engineering: C, 2017
EPJ Web of Conferences, 2016
Radiation Physics and Chemistry, 2016
Physica medica : PM : an international journal devoted to the applications of physics to medicine and biology : official journal of the Italian Association of Biomedical Physics (AIFB), 2001
Unanticipated late effects in neutron and heavy ion therapy, not attributable to overdose, imply ... more Unanticipated late effects in neutron and heavy ion therapy, not attributable to overdose, imply a qualitative difference between low and high LET therapy. We identify that difference as 'ion kill', associated with the spectrum of z/beta in the radiation field, whose measurement we label 'ion-kill dosimetry'.
Radiation Physics and Chemistry, 2021
Radiation Measurements, 2001
Polymer Degradation and Stability, 2019
Abstract This review paper intends at identifying the early processes arising during the formatio... more Abstract This review paper intends at identifying the early processes arising during the formation of a latent ion track in Poly Allyl Diglycol Carbonate (PADC). We briefly summarize the physical and chemical processes specific to the description of the interaction of ionizing radiation with matter. Then we gather published information in relation to PADC response regarding energy absorption and further transient species formation. Emphasis is given to the chemistry of radicals. Due to a lack of available data in relation with clearly identified unpaired electron carriers in PADC, we use data stemming from surrogate molecules. Based on such data we suggest mechanisms for the decomposition of PADC during the early times of ion track formation. The α-sites of ether functional groups in PADC appear undoubtedly as critical targets which during further decomposition behave as the most probable origin of Carbon dioxide release. All suggested mechanisms are multi-step processes. Combining different concepts and data in relation with the dynamics of transient species formed in the ion track of a polymer material, we propose that the effective track radius may be described as the radial extension of reactive species formed rather than the maximum distance at which δ-rays escape out of ion's trajectory. Lastly, generalization of the different processes collected allows two major pathways to be proposed for describing the fate of damaged ether moieties in PADC. This way, evidence is given for a higher sensitivity of ether functional groups compared to ester carbonate ones. The latter generally being destroyed as a consequence of prior damaging of the ether group. Discussion presented here is of interest to the nuclear track community.
The Journal of Physical Chemistry C
Journal of photochemistry and photobiology. B, Biology, 2018
The oxidation of proteins results in their deterioration via the oxidation of reactive amino acid... more The oxidation of proteins results in their deterioration via the oxidation of reactive amino acids. Oxidation of the amino acid, methionine plays an important role during biological conditions of oxidative stress, and equally a role in protein stability. In this study the oxidation of the methionine residue using the tripeptide GlyMetGly with respect to hydrogen peroxide has been studied using both Raman spectroscopy and DFT calculations. Spectral modifications following the formation of methionine sulfoxide are shown with the appearance of the SO vibration whilst there is also the modification of the CS vibrations at approximately 700 cm. The changes in the intensity of the CS stretching band were used to calculate the kinetic rate constant as 7.9 ± 0.6 × 10 dm mol s. The energy barrier for the reaction. is determined both experimentally and using DFT calculations. The reaction of the dairy protein beta-lactoglobulin with hydrogen peroxide is equally studied using the same techniqu...
Radiation Research, Jun 1, 2009
Radiation Measurements, Aug 1, 2008
Surface Science, Jan 7, 2013