Giovanni Di Domenico | Università degli Studi di Ferrara (original) (raw)
Papers by Giovanni Di Domenico
Physical Review A, Feb 16, 2000
... 22 ; ( KK ) E , values derived from the experiment of Ertugrul et al. 23 . K ( Element Gd Dy ... more ... 22 ; ( KK ) E , values derived from the experiment of Ertugrul et al. 23 . K ( Element Gd Dy Er Z 64 66 68 KK ) PS barn ( KK ) H2S ( KK) F ( KK) B ( KK) E barn 2673 barn 2319 30 2591 47 2800 50 barn 2270 112 2623 132 barn 2299 155 2554 135 2825 175 2327 2585 2842 ...
Applied Radiation and Isotopes, 2000
The suitability of introducing molecular interference effects into coherent scattering phenomenol... more The suitability of introducing molecular interference effects into coherent scattering phenomenology is considered here in the case of X and gamma photon transport in biological tissues. In order to make its implementation practicable in most of the existing open user Monte Carlo codes, a self-consistent basic set of tabulations for the linear differential scattering coefficient was proposed. The tabulations were critically reviewed by testing their validity over the entire range of the momentum transfer variable from 0 to 10(10) nm(-1). Implementation in three different Monte Carlo codes was performed, and they proved to be reliable.
Clinical and Translational Imaging, 2015
Substance P (SP) has been known to trigger biological responses by linking to NK 1 receptors. The... more Substance P (SP) has been known to trigger biological responses by linking to NK 1 receptors. The presence of functional NK1 receptors has already been documented in malignant brain tumors of glial origin, medullary thyroid cancer, non-small cell lung cancer and pancreatic carcinoma 99mTc and 188Re radiolabeled SP was tested for cell surface binding after incubation with NK1 receptor expressing U-87 MG cells, and negative control cell line L-929 and preliminary whole-body biodistribution studies were carried out with 99mTc labeled SP using a hybrid SPECT/CT YAP(S)PET small-animal tomography scanner. Our results using 99mTc and 188Re radiolabeled SP, demonstrated the affinity of these radioconjugates for NK1 receptor expressing cells, showing pronounced cell surface binding after incubation with U-87 MG cells, compared to the negative control cell line L-929. Further preliminary whole-body biodistribution studies with 99mTc labeled SP using a hybrid SPECT/CT YAP(S)PET small animal to...
The Identification of Dark Matter, 2003
In the PVLAS apparatus a polarised laser beam is used to probe the structure of quantum vacuum wh... more In the PVLAS apparatus a polarised laser beam is used to probe the structure of quantum vacuum when it is perturbed by an external magnetic field. The photon-photon scattering process, taking place in the field region, could result in the production of light scalar/pseudoscalar particles coupled to two photons thought to be dark matter candidates. The photon-photon scattering induces a
The Identification of Dark Matter, 2001
The PVLAS experiment is designed to study photon-photon interactions in the low energy region usi... more The PVLAS experiment is designed to study photon-photon interactions in the low energy region using optical techniques. In the PVLAS apparatus photons from a laser beam interact in vacuum with an external magnetic field, and the two-photon interaction results in the possible production of neutral, nearly massless, scalar/pseudoscalar particles. Evidence of particle production is extracted from the study of the light polarisation state after traversing a region where a the magnetic field is provided by a superconducting dipole magnet. Polarisation measurements are conducted using a very sensitive ellipsometer based on a high finesse (~100000), 6.4 m long, Fabry-Perot optical resonator. The PVLAS apparatus is now fully integrated and operational: the first commissioning run with a 4.0 T field has been successfully completed, the first data taking runs have been conducted, yielding a total integration time of about 20 hours, and data analysis is now in progress. We will present details from the commissioning run and preliminary results from the data runs
IEEE Symposium Conference Record Nuclear Science 2004.
Multimodality simultaneous functional and morphological imaging is being pursued by several resea... more Multimodality simultaneous functional and morphological imaging is being pursued by several research groups. In this line of research the high resolution YAP-(S)PET small animal integrated PET-SPECT imaging system, constructed by our group of medical physics at the University of Ferrara, is being upgraded with a computed tomography (CT). In this way it will be possible to perform in vivo molecular
Physical Review A, 1991
Accurate measurements, within 1.6%%uo, of the cross section of K radiation emission of Mo, Cd, an... more Accurate measurements, within 1.6%%uo, of the cross section of K radiation emission of Mo, Cd, and Sn at 59.54-keV photon energy were carried out. The results are compared with those of other experiments, and they confirm the great reliability of the combination of up-to-date tabulations of K fluorescence yields and photoeffect cross-section values calculated by relativistic quantum-mechanics models.
Chemical Physics Letters, 2004
In this Letter we report a novel measurement of the magnetically induced birefringence (Cotton-Mo... more In this Letter we report a novel measurement of the magnetically induced birefringence (Cotton-Mouton effect) in krypton and xenon. The measurement is performed, with the apparatus of the PVLAS experiment, at the previously uninvestigated wavelength of 1064 nm.
Veins and Lymphatics, 2017
The quantification of venous flows can be obtained by multiplying cross sectional area, measured ... more The quantification of venous flows can be obtained by multiplying cross sectional area, measured on a B-mode video-clip, by velocity values, obtained with Doppler measurements. The Doppler angle between ultrasound (US) line and blood flow requires a manual adjustment. Establishing this parameter is critical in order to calculate blood velocity. However, the operator dependency gives high variable results. It is worth noting that a new class of vector Doppler devices can enhance the accuracy and precision of measurements. Such technology uses a double US line that leads to automatically know the Doppler angle. By comparing in an…
Clinical and Translational Imaging, 2015
The objective of this work is to apply molecular imaging techniques, based on the administration ... more The objective of this work is to apply molecular imaging techniques, based on the administration of radioactive tracers in small animal models as a method to investigate the mechanisms of receptor interactions of drugs of abuse. A further objective of the study was to establish, in collaboration with the pharmacology unit of the University of Ferrara, a ‘‘pre-clinical research network’’ able to rapidly investigate the neurobiological mechanisms and the pharmacological effects induced by acute and chronic administration of Novel Psychoactive Substances (NPS) seized by law enforcement agencies
2014 19th IEEE-NPSS Real Time Conference, 2014
CPU vs GPU While a CPU executes programs serially a GPU is tailored for highly parallel operation... more CPU vs GPU While a CPU executes programs serially a GPU is tailored for highly parallel operation GPUs have many parallel execution units (cores) and higher transistor counts, while CPUs have few execution units and higher clock speeds GPUs have significantly faster and more advanced memory interfaces as they need to move around a lot more data tha CPUs A GPU is for the most part deterministic in its operations
Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2003
The preparation, characterization, and first biologic evaluation in rats of a novel class of mono... more The preparation, characterization, and first biologic evaluation in rats of a novel class of monocationic (99m)Tc heart imaging agents are reported. The complexes are represented by the general formula [(99m)Tc(N)(PNP)(L)](+), where L is the monoanionic form of a dithiocarbamate ligand of the type [R(1)(R(2))-N-C(=S)S](-), PNP is a diphosphine ligand of the type [(R(3))(2)P-(CH(2))(2)](2)-N(R(4)), and R(1)-R(4) are organic functional groups. The new complexes were prepared by use of both liquid and freeze-dried formulations through a 2-step procedure. The first step involved the formation of the [TcN](2+) group through the reaction of (99m)TcO(4)(-) with succinic dihydrazide as a donor of nitride nitrogen atoms (N(3-)) in the presence of Sn(2+) ions. This step was followed by the simultaneous addition to the reaction solution of the ligand PNP and of the sodium salt of the dithiocarbamate ligand (NaL) to afford the final products, [(99m)Tc(N)(PNP)(L)](+). The chemical identities of ...
2001 IEEE Nuclear Science Symposium Conference Record (Cat. No.01CH37310)
We have successfully built and characterized small animal PET scanner based on 4 rotating planar ... more We have successfully built and characterized small animal PET scanner based on 4 rotating planar detector heads. Each detector module is composed of a matrix of 400 YAP:Ce finger crystals (2×2×30 mm3 each) directly coupled to position sensitive photomultipliers (Hamamatsu R2486-06). By applying two high resolution collimators to two opposite detectors we realised an integrated PET-SPECT scanner for small animals. At present, at the Department of Experimental and Clinical Medicine of the University of Ferrara, the scanner is employed in small animal SPECT studies with 99mTc labeled radiotracers dedicated to obtain quantitative activity measurement in region of interest (ROI) directly from a reconstructed image of a in-vivo rat, with respect to the traditional ex-vivo measurement of activity with gamma counters. To achieve this goal, the scanner was calibrated referring it to a Isodose dose calibrator based on Geiger-Muller counters which previously underwent an absolute calibration with a known activity source. Preliminary results on quantitative tomographic heart perfusion and planar heart biokinetics studies are reported.
2002 IEEE Nuclear Science Symposium Conference Record
Advanced Technology & Particle Physics - Proceedings of the 7th International Conference on ICATPP-7, 2002
ABSTRACT
Advanced Monte Carlo for Radiation Physics, Particle Transport Simulation and Applications, 2001
Changes to the general purpose EGS4 code were performed in order to include anomalous dispersion ... more Changes to the general purpose EGS4 code were performed in order to include anomalous dispersion effects in the simulation of elastic scattering from atomic bound electrons. Moreover, experimental checks with 59.54 keV photons incident on Hf and Pb targets, at 90° and 120° scattering angles, were carried out.
Physical Review A, Feb 16, 2000
... 22 ; ( KK ) E , values derived from the experiment of Ertugrul et al. 23 . K ( Element Gd Dy ... more ... 22 ; ( KK ) E , values derived from the experiment of Ertugrul et al. 23 . K ( Element Gd Dy Er Z 64 66 68 KK ) PS barn ( KK ) H2S ( KK) F ( KK) B ( KK) E barn 2673 barn 2319 30 2591 47 2800 50 barn 2270 112 2623 132 barn 2299 155 2554 135 2825 175 2327 2585 2842 ...
Applied Radiation and Isotopes, 2000
The suitability of introducing molecular interference effects into coherent scattering phenomenol... more The suitability of introducing molecular interference effects into coherent scattering phenomenology is considered here in the case of X and gamma photon transport in biological tissues. In order to make its implementation practicable in most of the existing open user Monte Carlo codes, a self-consistent basic set of tabulations for the linear differential scattering coefficient was proposed. The tabulations were critically reviewed by testing their validity over the entire range of the momentum transfer variable from 0 to 10(10) nm(-1). Implementation in three different Monte Carlo codes was performed, and they proved to be reliable.
Clinical and Translational Imaging, 2015
Substance P (SP) has been known to trigger biological responses by linking to NK 1 receptors. The... more Substance P (SP) has been known to trigger biological responses by linking to NK 1 receptors. The presence of functional NK1 receptors has already been documented in malignant brain tumors of glial origin, medullary thyroid cancer, non-small cell lung cancer and pancreatic carcinoma 99mTc and 188Re radiolabeled SP was tested for cell surface binding after incubation with NK1 receptor expressing U-87 MG cells, and negative control cell line L-929 and preliminary whole-body biodistribution studies were carried out with 99mTc labeled SP using a hybrid SPECT/CT YAP(S)PET small-animal tomography scanner. Our results using 99mTc and 188Re radiolabeled SP, demonstrated the affinity of these radioconjugates for NK1 receptor expressing cells, showing pronounced cell surface binding after incubation with U-87 MG cells, compared to the negative control cell line L-929. Further preliminary whole-body biodistribution studies with 99mTc labeled SP using a hybrid SPECT/CT YAP(S)PET small animal to...
The Identification of Dark Matter, 2003
In the PVLAS apparatus a polarised laser beam is used to probe the structure of quantum vacuum wh... more In the PVLAS apparatus a polarised laser beam is used to probe the structure of quantum vacuum when it is perturbed by an external magnetic field. The photon-photon scattering process, taking place in the field region, could result in the production of light scalar/pseudoscalar particles coupled to two photons thought to be dark matter candidates. The photon-photon scattering induces a
The Identification of Dark Matter, 2001
The PVLAS experiment is designed to study photon-photon interactions in the low energy region usi... more The PVLAS experiment is designed to study photon-photon interactions in the low energy region using optical techniques. In the PVLAS apparatus photons from a laser beam interact in vacuum with an external magnetic field, and the two-photon interaction results in the possible production of neutral, nearly massless, scalar/pseudoscalar particles. Evidence of particle production is extracted from the study of the light polarisation state after traversing a region where a the magnetic field is provided by a superconducting dipole magnet. Polarisation measurements are conducted using a very sensitive ellipsometer based on a high finesse (~100000), 6.4 m long, Fabry-Perot optical resonator. The PVLAS apparatus is now fully integrated and operational: the first commissioning run with a 4.0 T field has been successfully completed, the first data taking runs have been conducted, yielding a total integration time of about 20 hours, and data analysis is now in progress. We will present details from the commissioning run and preliminary results from the data runs
IEEE Symposium Conference Record Nuclear Science 2004.
Multimodality simultaneous functional and morphological imaging is being pursued by several resea... more Multimodality simultaneous functional and morphological imaging is being pursued by several research groups. In this line of research the high resolution YAP-(S)PET small animal integrated PET-SPECT imaging system, constructed by our group of medical physics at the University of Ferrara, is being upgraded with a computed tomography (CT). In this way it will be possible to perform in vivo molecular
Physical Review A, 1991
Accurate measurements, within 1.6%%uo, of the cross section of K radiation emission of Mo, Cd, an... more Accurate measurements, within 1.6%%uo, of the cross section of K radiation emission of Mo, Cd, and Sn at 59.54-keV photon energy were carried out. The results are compared with those of other experiments, and they confirm the great reliability of the combination of up-to-date tabulations of K fluorescence yields and photoeffect cross-section values calculated by relativistic quantum-mechanics models.
Chemical Physics Letters, 2004
In this Letter we report a novel measurement of the magnetically induced birefringence (Cotton-Mo... more In this Letter we report a novel measurement of the magnetically induced birefringence (Cotton-Mouton effect) in krypton and xenon. The measurement is performed, with the apparatus of the PVLAS experiment, at the previously uninvestigated wavelength of 1064 nm.
Veins and Lymphatics, 2017
The quantification of venous flows can be obtained by multiplying cross sectional area, measured ... more The quantification of venous flows can be obtained by multiplying cross sectional area, measured on a B-mode video-clip, by velocity values, obtained with Doppler measurements. The Doppler angle between ultrasound (US) line and blood flow requires a manual adjustment. Establishing this parameter is critical in order to calculate blood velocity. However, the operator dependency gives high variable results. It is worth noting that a new class of vector Doppler devices can enhance the accuracy and precision of measurements. Such technology uses a double US line that leads to automatically know the Doppler angle. By comparing in an…
Clinical and Translational Imaging, 2015
The objective of this work is to apply molecular imaging techniques, based on the administration ... more The objective of this work is to apply molecular imaging techniques, based on the administration of radioactive tracers in small animal models as a method to investigate the mechanisms of receptor interactions of drugs of abuse. A further objective of the study was to establish, in collaboration with the pharmacology unit of the University of Ferrara, a ‘‘pre-clinical research network’’ able to rapidly investigate the neurobiological mechanisms and the pharmacological effects induced by acute and chronic administration of Novel Psychoactive Substances (NPS) seized by law enforcement agencies
2014 19th IEEE-NPSS Real Time Conference, 2014
CPU vs GPU While a CPU executes programs serially a GPU is tailored for highly parallel operation... more CPU vs GPU While a CPU executes programs serially a GPU is tailored for highly parallel operation GPUs have many parallel execution units (cores) and higher transistor counts, while CPUs have few execution units and higher clock speeds GPUs have significantly faster and more advanced memory interfaces as they need to move around a lot more data tha CPUs A GPU is for the most part deterministic in its operations
Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2003
The preparation, characterization, and first biologic evaluation in rats of a novel class of mono... more The preparation, characterization, and first biologic evaluation in rats of a novel class of monocationic (99m)Tc heart imaging agents are reported. The complexes are represented by the general formula [(99m)Tc(N)(PNP)(L)](+), where L is the monoanionic form of a dithiocarbamate ligand of the type [R(1)(R(2))-N-C(=S)S](-), PNP is a diphosphine ligand of the type [(R(3))(2)P-(CH(2))(2)](2)-N(R(4)), and R(1)-R(4) are organic functional groups. The new complexes were prepared by use of both liquid and freeze-dried formulations through a 2-step procedure. The first step involved the formation of the [TcN](2+) group through the reaction of (99m)TcO(4)(-) with succinic dihydrazide as a donor of nitride nitrogen atoms (N(3-)) in the presence of Sn(2+) ions. This step was followed by the simultaneous addition to the reaction solution of the ligand PNP and of the sodium salt of the dithiocarbamate ligand (NaL) to afford the final products, [(99m)Tc(N)(PNP)(L)](+). The chemical identities of ...
2001 IEEE Nuclear Science Symposium Conference Record (Cat. No.01CH37310)
We have successfully built and characterized small animal PET scanner based on 4 rotating planar ... more We have successfully built and characterized small animal PET scanner based on 4 rotating planar detector heads. Each detector module is composed of a matrix of 400 YAP:Ce finger crystals (2×2×30 mm3 each) directly coupled to position sensitive photomultipliers (Hamamatsu R2486-06). By applying two high resolution collimators to two opposite detectors we realised an integrated PET-SPECT scanner for small animals. At present, at the Department of Experimental and Clinical Medicine of the University of Ferrara, the scanner is employed in small animal SPECT studies with 99mTc labeled radiotracers dedicated to obtain quantitative activity measurement in region of interest (ROI) directly from a reconstructed image of a in-vivo rat, with respect to the traditional ex-vivo measurement of activity with gamma counters. To achieve this goal, the scanner was calibrated referring it to a Isodose dose calibrator based on Geiger-Muller counters which previously underwent an absolute calibration with a known activity source. Preliminary results on quantitative tomographic heart perfusion and planar heart biokinetics studies are reported.
2002 IEEE Nuclear Science Symposium Conference Record
Advanced Technology & Particle Physics - Proceedings of the 7th International Conference on ICATPP-7, 2002
ABSTRACT
Advanced Monte Carlo for Radiation Physics, Particle Transport Simulation and Applications, 2001
Changes to the general purpose EGS4 code were performed in order to include anomalous dispersion ... more Changes to the general purpose EGS4 code were performed in order to include anomalous dispersion effects in the simulation of elastic scattering from atomic bound electrons. Moreover, experimental checks with 59.54 keV photons incident on Hf and Pb targets, at 90° and 120° scattering angles, were carried out.