Emerging colistin resistance in Salmonella enterica serovar Newport isolates from human infections (original) (raw)

journal contribution

posted on 2020-03-03, 09:08 authored by Mohammed Elbediwi, Hang Pan, Silpak Biswas, Yan Li, Min Yue

Worldwide emergence of Salmonella enterica serovar Newport (S. Newport) infection in humans, in parallel with a significant increasing prevalence of antimicrobial resistance (AR), is a serious public health concern. However, the prevalence of S. Newport resistance in China remains largely unknown. A retrospective study of 287 S. Newport clinical isolates collected during 1997–2018 was undertaken for characterization of AR profiles using the micro-dilution assay. We found a recent emergence of colistin resistance in four Chinese clinical isolates, including _mcr_-1-positive isolates. Importantly, phylogenomic and microbiological investigations indicate multiple independent clonal transmission of colistin-resistant S. Newport isolates of different seafood origins. Our study highlights potential reservoirs for transmission of colistin resistance and suggests that the global food supply chain may facilitate this dissemination.

Funding

This work was supported by the National Program on Key Research Project of China [grant number 2017YFC1600103, 2018YFD0500501, SQ2019YFE010999] as well as Horizon 2020 Framework Programme under Grant Agreement No. 861917 – SAFFI and Zhejiang Provincial Natural Science Foundation [grant number LR19C180001].

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