Michele Machado | FURG - Universidade Federal do Rio Grande (original) (raw)

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Papers by Michele Machado

Research paper thumbnail of FoxPeer: Navigating the Web with Community Recommendations

The web holds a large number of resources, and navigating can sometimes become hard. As individua... more The web holds a large number of resources, and navigating can sometimes become hard. As individuals get together to discuss and exchange information, web based communities start to form. These communities form a nexus around which individuals organize and learn. As they grow and accumulate shared resources, they become rich information sources. The usual way to navigate the web is to search, starting from a search page and then browsing to look for adequate resources. When looking for information, individuals often turn to others for recommendations or answers. This paper presents a peer-to-peer tool to assist web navigation and search by leveraging a community's existent knowledge. Individuals rate web sites and share these ratings with the community. Recommendations are made based on these ratings. This enables a community-geared rating, where individuals know they will find ratings that reflect the opinions of the community in which he or she is inserted. This mimics the recommendation-seeking behavior and has the potential to lead to better results, as searches become more directed to a community's context.

Research paper thumbnail of Community-supported collaborative navigation with FoxPeer

International Journal of Web Based Communities, 2009

Navigating the web with its large number of resources can sometimes be hard. Web-based communitie... more Navigating the web with its large number of resources can sometimes be hard. Web-based communities form as individuals get together to discuss and exchange information. These communities provide a nexus around which individuals organise and learn. As they grow and accumulate shared resources, they become rich information sources. The usual way to navigate the web is to search, starting from a search page and then browsing to look for adequate resources. However, when looking for information, individuals often turn to others for recommendations or answers. This paper presents a peer-to-peer tool to assist in web navigation and searches by leveraging a community's existing knowledge. Individuals rate websites and share these ratings with the community. Recommendations are made based on these ratings. This enables a community-geared rating, where individuals know they will find ratings that reflect the opinions of the community in which he or she is inserted. This mimics recommendation-seeking behaviour and has the potential to lead to better results as searches become more directed towards a community's context.

Research paper thumbnail of FoxPeer: Navigating the Web with Community Recommendations

The web holds a large number of resources, and navigating can sometimes become hard. As individua... more The web holds a large number of resources, and navigating can sometimes become hard. As individuals get together to discuss and exchange information, web based communities start to form. These communities form a nexus around which individuals organize and learn. As they grow and accumulate shared resources, they become rich information sources. The usual way to navigate the web is to search, starting from a search page and then browsing to look for adequate resources. When looking for information, individuals often turn to others for recommendations or answers. This paper presents a peer-to-peer tool to assist web navigation and search by leveraging a community's existent knowledge. Individuals rate web sites and share these ratings with the community. Recommendations are made based on these ratings. This enables a community-geared rating, where individuals know they will find ratings that reflect the opinions of the community in which he or she is inserted. This mimics the recommendation-seeking behavior and has the potential to lead to better results, as searches become more directed to a community's context.

Research paper thumbnail of Protective Effects of Extracts and Flavonoids Isolated from Scutia buxifolia Reissek against Chromosome Damage in Human Lymphocytes Exposed to Hydrogen Peroxide

Molecules, 2012

Flavonoids are claimed to protect against cardiovascular disease, certain forms of cancer and age... more Flavonoids are claimed to protect against cardiovascular disease, certain forms of cancer and ageing, possibly by preventing initial DNA damage. Therefore, we investigated the protective effects of crude extract, ethyl acetate fraction and flavonoids (quercetin, quercitrin, isoquercitrin and rutin) isolated from the leaves from Scutia buxifolia against chromosome damage induced by H 2 O 2 in human lymphocytes by analyzing cellular growth rate, cell viability, mitotic index and chromosomal instability. We found a differential response among the compounds tested, with the ethyl acetate fraction being more effective than the crude extract, a difference perhaps related to the presence of the antioxidants identified and quantified by HPLC/DAD. In general, quercetin, isoquercitrin and rutin recovered the mitotic index and chromosomal instability more than quercitrin after treatment with hydrogen peroxide.

Research paper thumbnail of EDUCAÇÃO PROFISSIONAL CONTINUADA: ESTUDO DA SUA EFETIVIDADE NO ESTADO DE GOIÁS

ccontabeis.com.br

Page 1. 18º CONGRESSO BRASILEIRO DE CONTABILIDADE • 24 A 28 DE AGOSTO DE 2008 • GRAMADO-RS ANAIS ... more Page 1. 18º CONGRESSO BRASILEIRO DE CONTABILIDADE • 24 A 28 DE AGOSTO DE 2008 • GRAMADO-RS ANAIS DOS TRABALHOS CIENTÍFICOS EDUCAÇÃO E PESQUISA EM CONTABILIDADE CÓD. DO TRAB. 142 1 ...

Research paper thumbnail of Toxicological effects of ultraviolet radiation on lymphocyte cells with different manganese superoxide dismutase Ala16Val polymorphism genotypes

Toxicology in Vitro, 2010

The aim of this study was to investigate whether there is a differential response of lymphocytes ... more The aim of this study was to investigate whether there is a differential response of lymphocytes from healthy MnSOD genotype subjects to oxidative stress. We used UV radiation as a toxic agent due to its genotoxic effects associated with chromosome aberrations caused by breaks in the DNA strands. Cellular growth rate, cell viability, mitotic index, chromosomal instability and biomarkers of oxidative metabolism were analysed in lymphocyte cells from healthy adults with different Ala16Val MnSOD polymorphisms that produce tree genotypes: AA, VV and AV. We found a differential response to UV exposure in cultures of lymphocyte cells from Ala16Val genotype donors. In general, AA cell cultures presented higher viability and mitotic index and lower TBARS levels than VV and AV cells for both the control and UV exposure groups. However, when we compared the DNA damage among the three genotypes, AA lymphocyte cells presented the highest damage from UV exposure. These data suggest that the Ala16-Val polymorphism affects the response of cellular oxidative metabolism in different ways.

Research paper thumbnail of FoxPeer: Navigating the Web with Community Recommendations

The web holds a large number of resources, and navigating can sometimes become hard. As individua... more The web holds a large number of resources, and navigating can sometimes become hard. As individuals get together to discuss and exchange information, web based communities start to form. These communities form a nexus around which individuals organize and learn. As they grow and accumulate shared resources, they become rich information sources. The usual way to navigate the web is to search, starting from a search page and then browsing to look for adequate resources. When looking for information, individuals often turn to others for recommendations or answers. This paper presents a peer-to-peer tool to assist web navigation and search by leveraging a community's existent knowledge. Individuals rate web sites and share these ratings with the community. Recommendations are made based on these ratings. This enables a community-geared rating, where individuals know they will find ratings that reflect the opinions of the community in which he or she is inserted. This mimics the recommendation-seeking behavior and has the potential to lead to better results, as searches become more directed to a community's context.

Research paper thumbnail of Community-supported collaborative navigation with FoxPeer

International Journal of Web Based Communities, 2009

Navigating the web with its large number of resources can sometimes be hard. Web-based communitie... more Navigating the web with its large number of resources can sometimes be hard. Web-based communities form as individuals get together to discuss and exchange information. These communities provide a nexus around which individuals organise and learn. As they grow and accumulate shared resources, they become rich information sources. The usual way to navigate the web is to search, starting from a search page and then browsing to look for adequate resources. However, when looking for information, individuals often turn to others for recommendations or answers. This paper presents a peer-to-peer tool to assist in web navigation and searches by leveraging a community's existing knowledge. Individuals rate websites and share these ratings with the community. Recommendations are made based on these ratings. This enables a community-geared rating, where individuals know they will find ratings that reflect the opinions of the community in which he or she is inserted. This mimics recommendation-seeking behaviour and has the potential to lead to better results as searches become more directed towards a community's context.

Research paper thumbnail of FoxPeer: Navigating the Web with Community Recommendations

The web holds a large number of resources, and navigating can sometimes become hard. As individua... more The web holds a large number of resources, and navigating can sometimes become hard. As individuals get together to discuss and exchange information, web based communities start to form. These communities form a nexus around which individuals organize and learn. As they grow and accumulate shared resources, they become rich information sources. The usual way to navigate the web is to search, starting from a search page and then browsing to look for adequate resources. When looking for information, individuals often turn to others for recommendations or answers. This paper presents a peer-to-peer tool to assist web navigation and search by leveraging a community's existent knowledge. Individuals rate web sites and share these ratings with the community. Recommendations are made based on these ratings. This enables a community-geared rating, where individuals know they will find ratings that reflect the opinions of the community in which he or she is inserted. This mimics the recommendation-seeking behavior and has the potential to lead to better results, as searches become more directed to a community's context.

Research paper thumbnail of Protective Effects of Extracts and Flavonoids Isolated from Scutia buxifolia Reissek against Chromosome Damage in Human Lymphocytes Exposed to Hydrogen Peroxide

Molecules, 2012

Flavonoids are claimed to protect against cardiovascular disease, certain forms of cancer and age... more Flavonoids are claimed to protect against cardiovascular disease, certain forms of cancer and ageing, possibly by preventing initial DNA damage. Therefore, we investigated the protective effects of crude extract, ethyl acetate fraction and flavonoids (quercetin, quercitrin, isoquercitrin and rutin) isolated from the leaves from Scutia buxifolia against chromosome damage induced by H 2 O 2 in human lymphocytes by analyzing cellular growth rate, cell viability, mitotic index and chromosomal instability. We found a differential response among the compounds tested, with the ethyl acetate fraction being more effective than the crude extract, a difference perhaps related to the presence of the antioxidants identified and quantified by HPLC/DAD. In general, quercetin, isoquercitrin and rutin recovered the mitotic index and chromosomal instability more than quercitrin after treatment with hydrogen peroxide.

Research paper thumbnail of EDUCAÇÃO PROFISSIONAL CONTINUADA: ESTUDO DA SUA EFETIVIDADE NO ESTADO DE GOIÁS

ccontabeis.com.br

Page 1. 18º CONGRESSO BRASILEIRO DE CONTABILIDADE • 24 A 28 DE AGOSTO DE 2008 • GRAMADO-RS ANAIS ... more Page 1. 18º CONGRESSO BRASILEIRO DE CONTABILIDADE • 24 A 28 DE AGOSTO DE 2008 • GRAMADO-RS ANAIS DOS TRABALHOS CIENTÍFICOS EDUCAÇÃO E PESQUISA EM CONTABILIDADE CÓD. DO TRAB. 142 1 ...

Research paper thumbnail of Toxicological effects of ultraviolet radiation on lymphocyte cells with different manganese superoxide dismutase Ala16Val polymorphism genotypes

Toxicology in Vitro, 2010

The aim of this study was to investigate whether there is a differential response of lymphocytes ... more The aim of this study was to investigate whether there is a differential response of lymphocytes from healthy MnSOD genotype subjects to oxidative stress. We used UV radiation as a toxic agent due to its genotoxic effects associated with chromosome aberrations caused by breaks in the DNA strands. Cellular growth rate, cell viability, mitotic index, chromosomal instability and biomarkers of oxidative metabolism were analysed in lymphocyte cells from healthy adults with different Ala16Val MnSOD polymorphisms that produce tree genotypes: AA, VV and AV. We found a differential response to UV exposure in cultures of lymphocyte cells from Ala16Val genotype donors. In general, AA cell cultures presented higher viability and mitotic index and lower TBARS levels than VV and AV cells for both the control and UV exposure groups. However, when we compared the DNA damage among the three genotypes, AA lymphocyte cells presented the highest damage from UV exposure. These data suggest that the Ala16-Val polymorphism affects the response of cellular oxidative metabolism in different ways.