aliirfan rai | Govt.College University Faisalabad Pakistan (original) (raw)

Papers by aliirfan rai

Anthracenylamine and naphthylamine were reacted with 1, 3-cyclohexadienone and 1, 4-benzoquinone ... more Anthracenylamine and naphthylamine were reacted with 1, 3-cyclohexadienone and 1, 4-benzoquinone in order to prepare four (1, 2, 3 &
4) conjugated Schiff bases for the evaluation of their antibacterial as well as antifungal activities. The results of their activities were
compared with standard drugs against three strains of bacteria as well as three strains of fungi and they showed that the Schiff base 4
(C34H22N2O) exhibited good inhibition zones against all the strains of bacteria (10.74 ± 0.65, 10 ± 0.675, 10.65 ± 0.75 mm) as well as
fungi (9.15 ± 0.815, 10.25 ± 0.55, 10.5 ± 0.575 mm) as compared to others (1, 2 & 3). The Schiff base 3 (C26H24N4) showed better
potential for S. aureus (10 ± 0.856 mm) strain of bacteria and A. alternate (10.5 ± 2.150 mm) strain of fungi. Its activity against other two
strains of bacteria and fungi was also better than other two Schiff bases (1 & 2). The Schiff base 2 (C26H22N2) exhibited reasonable activity
against B. subtilus (10 ± 0.715 mm) and A. alternate (8.55 ± 0.015 mm). The compound (1) showed least antibacterial (4.5 ± 0.815, 5 ±
0.716, 4.75 ± 0.950 mm) as well as antifungal (4 ± 0.575, 4.15 ± 0.570, 6.5 ± 1.725 mm) activity. From the results it is concluded that
delocalization of p electrons has the positive influence on the antimicrobial potential of the titled Schiff bases. Thus these Schiff bases
may serve as a basis for the chemical modifications directed towards the development of a new class of antibacterial agents.
Keywords: Conjugated Schiff base, Bacterial strains, Fungal strains, Activity