Roshan Telrandhe | RTM Nagpur University Nagpur (original) (raw)

Papers by Roshan Telrandhe

Nanotechnology deals regulating matter at dimension of 1-100 nanometers. its use in fundamental p... more Nanotechnology deals regulating matter at dimension of 1-100 nanometers. its use in fundamental physics, biology, chemistry, technology of nanometer scale objects. It also includes how such objects can be used in the areas of computation, sensors, nanostructure materials, biolabeling, biomedical, agricultural, biolabeling , cancer, biotechnology. There are 3 methods for preparation of nanoparticles Physical, chemical &biological. Cancer is as an abnormal growth of cells. It is due to lack of proper regulation in cell cycle. Cancer develops through an accumulation of genetic changes or mutations which could emerge due to different factors like physical, chemical, biological. Currently available cancer chemotherapeutic agents insidiously affect the host cells especially bone marrow, epithelial tissues, reticule-endothelial system and gonads Because of high death rate associated with cancer and the serious side effects of chemotherapy & radiation therapy. Silver NanoParticles as an
Synthesis of Silver Nanoparticles 1]freshly prepared 1mM silver nitrate and stored under dark conditions with the plant extract. solution are prepared in ratio of 9:1(AgNO3:PlantExtract). 2]1 mM solution of AgNO3 prepared in an Erlenmeyer ﬂask. Then 1, 2, 3, 4 and 5 mL of plant extract was added separately to 10 mL of silver nitrate solution keeping its concentration at 1 mM. 3]AgNO3 (1mM-5mM) keeping extract concentration constant (1 mL) This setup was incubated in a dark chamber to minimize photoactivation of silver nitrate at room temperature. Result and Discussion
S. No Plant name Source of extract for synthesis of silver nanoparticle (AgNP)
Cancer cell lines (Human)
Size of silver nanoparticle(Ag NP) nm
Ic50 µg/ml
1 Citrullus colosynthis
Fruits, leaves, Seeds, roots
HCT-116, MCF7,Hep-G2, Caco2
Fruits-19.267 ,seeds-16.578 ,leaves-13.376 ,roots-7.398
(Fruits) HepG2 =17.2 & MCF7= 22.4 (leaves) HepG2=10.2, (roots) HCT116=21.2 & Hep-G2=22.4
2 Cissus quadrangularis
stem Hep-2 20-56 64
3 Origanum vulgare leaves A549 63-85 100
4 Sesbania grandiflora
leaves MCF-7 22 20
5 seaweed Ulva lactuca
Whole microalgea
Hep-2,MCF-7, HT-29
5-30 Hep-G2=12.5, MCF-7=37 & HT-29=49
6 Brassica oleracea Cauliflower florets
MCF-7 48 190.501
7 Seaweed Gelidiella sp.
Whole Seaweed
Hep-2 31.25 40-50
Table:Application of AgNP from plant extract used in different cell line
The cell line proliferation were significantly inhibited by AgNPs isolated from Jatropha
species with Jatropha curcus and Jatropha gossypifolia. The in vitro screening of the
AgNPs showed potential cytotoxic activity against the lung cancer cell lines A549.
Conclusion Silver nanoparticles in nano-biotechnology area has increased its importance to create ecofriendly; cost effective, stable nanoparticles and their applications in medicines, agriculture and electronics are wider. silver nanoparticles it is found that it is safer and better by using natural plants Phytochemical chemopreventiveagents are believed to play significant roles in controlling, inhibiting, and blocking signals which can cause translation of normal cells to cancer cells. .
chemotherapy & radiation therapy. Silver NanoParticles as an anticancer agent and they have all turned up positive. Many plantderived products have been reported to exhibit potent antitumour activity against several rodent and human cancer cell lines. Plants history about use in the treatment of cancer. It is significant that over 60% of currently used anticancer agents are derived, in one way or another, from natural sources (plants, marine organism)

Ophthalmic preparation are the sterile liquid or semisolid preparation meant to installation i... more Ophthalmic preparation are the sterile liquid or semisolid preparation meant to installation in to the eyes in the space between eye lids and eye ball . These product must be sterile and are prepare under the same condition as that of parenteral preparation

The aimed of current research to development of the simple, rapid and sensitive Differential spec... more The aimed of current research to development of the simple, rapid and sensitive Differential spectrophotometric method for the estimation of Verapamil in tablet dosage form. In this method two medium was use acid and alkaline and the difference spectrum was calculated. 0.1N HCL and 0.1N NaOH was used in this differential method. The λmax 278, beeers law limits 5-25µg/ml, regression equation Y= 0.024x-0.009, slope 0.024, intercept 0.09, correlation coefficient (r 2) 0.998, %RSD <1.5, % Recovery (Tablet) 100.46% was shows the good efficacy and results. This method future scope in quality control of the verapamine in simple, precise and economically and it recommended for the routine drug quality analysis investigation.

The aimed of current research to formulate herbal toothpaste utilizing plant extract like Neem le... more The aimed of current research to formulate herbal toothpaste utilizing plant extract like Neem leaves, Guava leaves, Cinnamon bark other ingredient are Camphor, Honey. The plant extract ingredient posses the anti-bacterial. The herbal toothpaste formulated which can satisfy all the required condition to keep the mouth fresh and prevent tooth decay by bacteria. The formulated herbal toothpaste compared with marketed preparation. Physical examination: Colour-greenish brown, smooth in nature, relative density-10.2, pH-8.2, Extrudability-90.37, spredability-Good and stable formulation. The anti-microbial evaluation against Staphylococcus aureus reveal that formulated herbal tooth paste exhibited notable activity with ZOI of 19.7 mm at MIC of 25μg/mL. the outcome of this research herbal toothpaste shows equal patronizing and engrossing passion over the marketed preparation it was consider after the comparing the marketed preparation(Colgate, Dabour Red, Dantkanti) with formulated herbal toothpaste. It has been good scope in future dental research and detal health of public.

The aimed of current research to formulate tooth gel utilizing leaf extract of Aloe vera. In mult... more The aimed of current research to formulate tooth gel utilizing leaf extract of Aloe vera. In multiple clinical studies, Aloe vera has used in dentistry for wound-healing effect, gingivitis, plaque control and curing oral mucosal lesions. Aloe vera is natural, ancient ingredient. The formulated Aloe vera tooth gel evaluated by physical examination: Colour-yellowish brown, Appearance-Homogeneous, smooth nature, Transparency-translucent and Relative density-10.5, No microbial growth in sample plate, pH7.5, Viscosity-310000cp, Extrudability amount percent-91.33, Spreadability-6.5cm/sec and obsereved good stability. The anti-microbial evaluation against Staphylococcus aureus reveal that formulated aloe vera tooth gel exhibited notable activity with ZOI of 19.5 mm at MIC of 25μg/mL. The outcome from this research evidently signified that the natural plant Aloe vera using to formulate tooth gel may be a new approach to formulate tooth gel economically and minimum side effect than synthetic formulation and good scope in future about dental research in natural remedies.

The current research aimed at fabricating plant extract mediated biosynthesized silver nanopartic... more The current research aimed at fabricating plant extract mediated biosynthesized silver nanoparticles (AgNPs) utilizing thorn extract of Bombax ceiba (TEBC). The synthesized AgNPs was characterized by UV spectroscopy where the surface plasmonic resonance peak (SPR) was located at 222 nm. The scanning electron microscopy (SEM) studies demonstrated that the morphology of fabricated nanomaterials was primarily cylindrical of average size of 20-30 nm with some spindles of size >50 nm. The anti-microbial evaluation against Staphylococcus aureus revealed that AgNPs exhibited notable activity with ZOI of 27.2 mm at MIC of 25 μg/mL. The outcome of this research evidently signified that the biofabricated AgNPs using TEBC may be a new greener approach or technology to formulate anti-bacterial nanodrugs in future.

The aimed of current research to development of the simple, rapid and sensitive Differential spec... more The aimed of current research to development of the simple, rapid and sensitive Differential spec-trophotometric method for the estimation of Vera-pamil in tablet dosage form. In this method two medium was use acid and alkaline and the difference spectrum was calculated. 0.1N HCL and 0.1N NaOH was used in this differential method. The λmax 278, Beers law limits 5-25µg/ml, regression equation Y= 0.024x-0.009, slope 0.024, intercept 0.09, correlation coefficient (r 2) 0.998, %RSD <1.5, % Recovery (Tablet) 100.46% was shows the good efficacy and results. This method future scope in quality control of the verapamil in simple, precise and economically and it recommended for the routine drug quality analysis investigation.

The aimed of current research to formulate herbal toothpaste utilizing plant extract like Neem le... more The aimed of current research to formulate herbal toothpaste utilizing plant extract like Neem leaves, Guava leaves, Cinnamon bark other ingredient are Camphor, Honey. The plant extract ingredient posses the anti-bacterial. The herbal toothpaste formulated which can satisfy all the required condition to keep the mouth fresh and prevent tooth decay by bacteria. The formulated herbal toothpaste compared with marketed preparation. Physical examination: Colour-greenish brown, smooth in nature, relative density-10.2, pH-8.2, Extrudabil-ity-90.37, spredability-Good and stable formulation. The anti-microbial evaluation against Staphylococcus aureus reveal that formulated herbal tooth paste exhibited notable activity with ZOI of 19.7 mm at MIC of 25μg/mL. the outcome of this research herbal toothpaste shows equal patronizing and engrossing passion over the marketed preparation it was consider after the comparing the marketed preparation(Colgate, Dabour Red, Dant-kanti) with formulated herbal toothpaste. It has been good scope in future dental research and det-al health of public.

INTERNATIONAL JOURNAL OF PHARMACEUTICS & DRUG ANALYSIS, 2017

The aimed of current research to formulate tooth gel utilizing leaf extract of Aloe vera. In mult... more The aimed of current research to formulate tooth gel utilizing leaf extract of Aloe vera. In multiple clinical studies, Aloe vera has used in dentistry for wound-healing effect, gingivitis, plaque control and curing oral mucosal lesions. Aloe vera is natural , ancient ingredient. The formulated Aloe vera tooth gel evaluated by physical examination: Colour -yellowish brown, Appearance-Homogeneous, smooth nature, Transparency-translucent and Relative density-10.5, No microbial growth in sample plate, pH-7.5, Viscosity-3100cp, Extrudability amount percent-91.33, Spreadability-6.5cm/sec and obsereved good stability. The anti-microbial evaluation against Staphylococcus aureus reveal that formulated aloe vera tooth gel exhibited notable activity with ZOI of 19.5 mm at MIC of 25μg/mL. The outcome from this research evidently signified that the natural plant Aloe vera using to formulate tooth gel may be a new approach to formulate tooth gel economically and minimum side effect than synthetic formulation and good scope in future about dental research in natural remedies.

INTERNATIONAL JOURNAL OF PHARMACEUTICS & DRUG ANALYSIS, 2017

The aimed of current research to formulate herbal toothpaste utilizing plant extract like Neem le... more The aimed of current research to formulate herbal toothpaste utilizing plant extract like Neem leaves, Guava leaves, Cinnamon bark other ingredient are Camphor, Honey. The plant extract ingredient posses the anti-bacterial. The herbal toothpaste formulated which can satisfy all the required condition to keep the mouth fresh and prevent tooth decay by bacteria. The formulated herbal toothpaste compared with marketed preparation. Physical examination: Colour-greenish brown, smooth in nature, relative density-10.2, pH-8.2, Extrudabil-ity-90.37, spredability-Good and stable formulation. The anti-microbial evaluation against Staphylococcus aureus reveal that formulated herbal tooth paste exhibited notable activity with ZOI of 19.7 mm at MIC of 25μg/mL. the outcome of this research herbal toothpaste shows equal patronizing and engrossing passion over the marketed preparation it was consider after the comparing the marketed preparation(Colgate, Dabour Red, Dant-kanti) with formulated herbal toothpaste. It has been good scope in future dental research and det-al health of public.

The aimed of current research to formulate tooth gel utilizing leaf extract of Aloe vera. In mult... more The aimed of current research to formulate tooth gel utilizing leaf extract of Aloe vera. In multiple clinical studies, Aloe vera has used in dentistry for wound-healing effect, gingivitis, plaque control and curing oral mucosal lesions. Aloe vera is natural , ancient ingredient. The formulated Aloe vera tooth gel evaluated by physical examination: Colour -yellowish brown, Appearance-Homogeneous, smooth nature, Transparency-translucent and Relative density-10.5, No microbial growth in sample plate, pH-7.5, Viscosity-3100cp, Extrudability amount percent-91.33, Spreadability-6.5cm/sec and obsereved good stability. The anti-microbial evaluation against Staphylococcus aureus reveal that formulated aloe vera tooth gel exhibited notable activity with ZOI of 19.5 mm at MIC of 25μg/mL. The outcome from this research evidently signified that the natural plant Aloe vera using to formulate tooth gel may be a new approach to formulate tooth gel economically and minimum side effect than synthetic formulation and good scope in future about dental research in natural remedies.

The current research aimed at fabricating plant extract mediated biosynthesized silver nanopar-ti... more The current research aimed at fabricating plant extract mediated biosynthesized silver nanopar-ticles (AgNPs) utilizing thorn extract of Bombax ceiba (TEBC). The synthesized AgNPs was characterized by UV spectroscopy where the surface plasmonic resonance peak (SPR) was located at 222 nm. The scanning electron microscopy (SEM) studies demonstrated that the morphology of fabricated nanomaterials was primarily cylindrical of average size of 20-30 nm with some spindles of size >50 nm. The anti-microbial evaluation against Staphylococcus aureus revealed that AgNPs exhibited notable activity with ZOI of 27.2 mm at MIC of 25 μg/mL. The outcome of this research evidently signified that the biofabricated AgNPs using TEBC may be a new greener approach or technology to formulate anti-bacterial nanodrugs in future.

This paper is an overview of advances and prospects in applications of nanotechnology for cancer ... more This paper is an overview of advances and prospects in applications of nanotechnology for cancer treatment. Nanotechnology is an use for prevention, diagnosis, and treatment .nanotechnology offer a promise for the targeted delivery of drugs, genes and protein to tumer tissue and therefore alleviating the toxicity of anticancer agent in healthy tissues. Cancer is one of the leading causes of death worldwide. Deaths from cancer are continuously rising worldwide with a projection of about 12 million deaths from cancer in 2030. . Nanotechnology is one of the most rapidly growing fields in the 21st century. Many different types of nanosystems have been utilized in diagnostics and therapeutics of various diseases. To subside the disadvantages of conventional cancer therapeutics, nanotechnology has been given considerable attention. In this paper, the current nanotechnologies that can be utilized in oncological interventions will be discussed. These mainly include arrays of nanocantilevers, nanotubes and nanowires for multiplexing detection, multifunctional injectable nanovectors for therapeutics and diagnostics. It is demonstrated how nanotechnology can help solve one of the most challenging and longstanding problems in medicine, which is how to eliminate cancer without harming normal body tissue. This article review current nanotechnology platforms for anticancer drug delivery, including polymeric nanoparticles, liposomes, dendrimers, nanoshells, carbon nanotubes,superparamagnetic nanoparticles and nuclear acid base nanoparticle [DNA, RNA interference (RNAi), and antisense oligonucleotide (ASO) ] as well as nanotechnologies for combination therapeutics strategies, for example, nanotechnologies combined with multidrug-resistance modulator, ultrasound, hyperthermia, or photodynamic therapy. The review increases awarnes of advantages in cancer therapy.

Conference Presentations by Roshan Telrandhe

The aimed of current research to development of the simple, rapid and sensitive Differential spec... more The aimed of current research to development of the simple, rapid and sensitive Differential spec-trophotometric method for the estimation of Vera-pamil in tablet dosage form. In this method two medium was use acid and alkaline and the difference spectrum was calculated. 0.1N HCL and 0.1N NaOH was used in this differential method. The λmax 278, Beers law limits 5-25µg/ml, regression equation Y= 0.024x-0.009, slope 0.024, intercept 0.09, correlation coefficient (r 2) 0.998, %RSD <1.5, % Recovery (Tablet) 100.46% was shows the good efficacy and results. This method future scope in quality control of the verapamil in simple, precise and economically and it recommended for the routine drug quality analysis investigation.

The aimed of current research to formulate herbal toothpaste utilizing plant extract like Neem le... more The aimed of current research to formulate herbal toothpaste utilizing plant extract like Neem leaves, Guava leaves, Cinnamon bark other ingredient are Camphor, Honey. The plant extract ingredient posses the anti-bacterial. The herbal toothpaste formulated which can satisfy all the required condition to keep the mouth fresh and prevent tooth decay by bacteria. The formulated herbal toothpaste compared with marketed preparation. Physical examination: Colour-greenish brown, smooth in nature, relative density-10.2, pH-8.2, Extrudabil-ity-90.37, spredability-Good and stable formulation. The anti-microbial evaluation against Staphylococcus aureus reveal that formulated herbal tooth paste exhibited notable activity with ZOI of 19.7 mm at MIC of 25μg/mL. the outcome of this research herbal toothpaste shows equal patronizing and engrossing passion over the marketed preparation it was consider after the comparing the marketed preparation(Colgate, Dabour Red, Dant-kanti) with formulated herbal toothpaste. It has been good scope in future dental research and det-al health of public.

INTERNATIONAL JOURNAL OF PHARMACEUTICS & DRUG ANALYSIS, 2017

The aimed of current research to formulate tooth gel utilizing leaf extract of Aloe vera. In mult... more The aimed of current research to formulate tooth gel utilizing leaf extract of Aloe vera. In multiple clinical studies, Aloe vera has used in dentistry for wound-healing effect, gingivitis, plaque control and curing oral mucosal lesions. Aloe vera is natural , ancient ingredient. The formulated Aloe vera tooth gel evaluated by physical examination: Colour -yellowish brown, Appearance-Homogeneous, smooth nature, Transparency-translucent and Relative density-10.5, No microbial growth in sample plate, pH-7.5, Viscosity-3100cp, Extrudability amount percent-91.33, Spreadability-6.5cm/sec and obsereved good stability. The anti-microbial evaluation against Staphylococcus aureus reveal that formulated aloe vera tooth gel exhibited notable activity with ZOI of 19.5 mm at MIC of 25μg/mL. The outcome from this research evidently signified that the natural plant Aloe vera using to formulate tooth gel may be a new approach to formulate tooth gel economically and minimum side effect than synthetic formulation and good scope in future about dental research in natural remedies.

INTERNATIONAL JOURNAL OF PHARMACEUTICS & DRUG ANALYSIS, 2017

The aimed of current research to formulate herbal toothpaste utilizing plant extract like Neem le... more The aimed of current research to formulate herbal toothpaste utilizing plant extract like Neem leaves, Guava leaves, Cinnamon bark other ingredient are Camphor, Honey. The plant extract ingredient posses the anti-bacterial. The herbal toothpaste formulated which can satisfy all the required condition to keep the mouth fresh and prevent tooth decay by bacteria. The formulated herbal toothpaste compared with marketed preparation. Physical examination: Colour-greenish brown, smooth in nature, relative density-10.2, pH-8.2, Extrudabil-ity-90.37, spredability-Good and stable formulation. The anti-microbial evaluation against Staphylococcus aureus reveal that formulated herbal tooth paste exhibited notable activity with ZOI of 19.7 mm at MIC of 25μg/mL. the outcome of this research herbal toothpaste shows equal patronizing and engrossing passion over the marketed preparation it was consider after the comparing the marketed preparation(Colgate, Dabour Red, Dant-kanti) with formulated herbal toothpaste. It has been good scope in future dental research and det-al health of public.

The aimed of current research to formulate tooth gel utilizing leaf extract of Aloe vera. In mult... more The aimed of current research to formulate tooth gel utilizing leaf extract of Aloe vera. In multiple clinical studies, Aloe vera has used in dentistry for wound-healing effect, gingivitis, plaque control and curing oral mucosal lesions. Aloe vera is natural , ancient ingredient. The formulated Aloe vera tooth gel evaluated by physical examination: Colour -yellowish brown, Appearance-Homogeneous, smooth nature, Transparency-translucent and Relative density-10.5, No microbial growth in sample plate, pH-7.5, Viscosity-3100cp, Extrudability amount percent-91.33, Spreadability-6.5cm/sec and obsereved good stability. The anti-microbial evaluation against Staphylococcus aureus reveal that formulated aloe vera tooth gel exhibited notable activity with ZOI of 19.5 mm at MIC of 25μg/mL. The outcome from this research evidently signified that the natural plant Aloe vera using to formulate tooth gel may be a new approach to formulate tooth gel economically and minimum side effect than synthetic formulation and good scope in future about dental research in natural remedies.

The aimed of current research to formulate tooth gel utilizing leaf extract of Aloe vera. In mult... more The aimed of current research to formulate tooth gel utilizing leaf extract of Aloe vera. In multiple clinical studies, Aloe vera has used in dentistry for wound-healing effect, gingivitis, plaque control and curing oral mucosal lesions. Aloe vera is natural, ancient ingredient. The formulated Aloe vera tooth gel evaluated by physical examination: Colour-yellowish brown, Appearance-Homogeneous, smooth nature, Transparency-translucent and Relative density-10.5, No microbial growth in sample plate, pH-7.5, Viscosity-310000cp, Extrudability amount percent-91.33, Spreadability-6.5cm/sec and obsereved good stability. The anti-microbial evaluation against Staphylococcus aureus reveal that formulated aloe vera tooth gel exhibited notable activity with ZOI of 19.5 mm at MIC of 25μg/mL. The outcome from this research evidently signified that the natural plant Aloe vera using to formulate tooth gel may be a new approach to formulate tooth gel economically and minimum side effect than synthetic formulation and good scope in future about dental research in natural remedies.