GitHub - fgeier/JohnsonKinaseData (original) (raw)

JohnsonKinaseData

JohnsonKinaseData is an R/ExperimentHubpackage providing access to position specific weight matrices (PWMs) for 303 human serine/threonine and 93 tyrosine kinases originally published in Johnson et al. and Yaron-Barir et al.

The package includes functionality to match PWMs against user-provided phosphosites and to convert PWM scores into percentile ranks using background score distributions.

All data records are available underhttps://zenodo.org/records/10628874 andhttps://zenodo.org/records/13785426according to open data standards and licenses under the Creative Commons Attribution 4.0 International license (CC-BY 4.0).

References

Johnson, J.L., Yaron, T.M., Huntsman, E.M. et al. An atlas of substrate specificities for the human serine/threonine kinome. Nature 613, 759–766 (2023). https://doi.org/10.1038/s41586-022-05575-3

Yaron-Barir, T.M., Joughin, B.A., Huntsman, E.M. et al. The intrinsic substrate specificity of the human tyrosine kinome. Nature 629, 1174–1181 (2024). https://doi.org/10.1038/s41586-024-07407-y