Christopher Copland | University of Glasgow (original) (raw)
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Papers by Christopher Copland
European Journal of Cancer, 2019
Paediatric Strategy Forums have been created by the multistakeholder organisation, ACCELERATE, an... more Paediatric Strategy Forums have been created by the multistakeholder organisation, ACCELERATE, and the European Medicines Agency to facilitate dialogue between all relevant stakeholders and suggest strategies in critical areas of paediatric oncology drug development. As there are many medicines being developed for B-cell malignancies in adults but comparatively few in children with these malignancies, a Paediatric Strategy Forum was held to discuss the best approach to develop these products for children. It was concluded that as current frontline therapy is highly successful, despite associated acute toxicity, de-escalation of this or substitution of presently used drugs with new medicines can only be undertaken when there is an effective salvage regimen, which is currently not available. Therefore priority should be given to developing treatment for patients with relapsed and refractory mature B-cell lymphomas. The consensus of the clinicians attending the meeting was that CAR Tcells, T-cell engagers and antibody drug conjugates (excluding those with a vinca alkaloidelike drug) presently have the greatest probability of providing benefit in relapse in view of their mechanism of action. However, as producing autologous CAR T-cells currently takes at least 4 weeks, they are not products which could be quickly employed initially at relapse in rapidly progressing mature B-cell malignancies but only for the consolidation phase of the treatment. Global, industry-supported, academic-sponsored studies testing compounds from different pharmaceutical companies simultaneously should be considered in rare populations, and it was proposed that an international working group be formed to develop an overarching clinical trials strategy for these disease groups. Future Forums are planned for other relevant paediatric oncologic diseases with a high unmet medical need and relevant molecular targets.
The present study documents an experimental and numerical investigation into the feasibility of g... more The present study documents an experimental and numerical investigation into the feasibility of generating longitudinal and transverse vortices in low speed wind tunnels. The longitudinal vortex system is that of a co-rotating vortex pair which, if substituted for a classical single tip vortex, may produce a beneficial modification to Blade Vortex Interaction. The transverse vortex mimics the tip vortex of a typical helicopter rotor and may be used to assess its effect when interacting with other aerofoils or fuselage components. Experiments have been conducted to investigate the flow field associated with two co-rotating vortices which represent the idealised vortex system associated with a novel rotor blade tip platform - the Westland Helicopters Vane Tip. These vortices were generated by two rectangular NACA 0015 half wings positioned upstream of the working section of a low speed wind tunnel. Hot-wire measurements were conducted downstream of the generators using x-wire probes t...
European Journal of Cancer, 2019
Paediatric Strategy Forums have been created by the multistakeholder organisation, ACCELERATE, an... more Paediatric Strategy Forums have been created by the multistakeholder organisation, ACCELERATE, and the European Medicines Agency to facilitate dialogue between all relevant stakeholders and suggest strategies in critical areas of paediatric oncology drug development. As there are many medicines being developed for B-cell malignancies in adults but comparatively few in children with these malignancies, a Paediatric Strategy Forum was held to discuss the best approach to develop these products for children. It was concluded that as current frontline therapy is highly successful, despite associated acute toxicity, de-escalation of this or substitution of presently used drugs with new medicines can only be undertaken when there is an effective salvage regimen, which is currently not available. Therefore priority should be given to developing treatment for patients with relapsed and refractory mature B-cell lymphomas. The consensus of the clinicians attending the meeting was that CAR Tcells, T-cell engagers and antibody drug conjugates (excluding those with a vinca alkaloidelike drug) presently have the greatest probability of providing benefit in relapse in view of their mechanism of action. However, as producing autologous CAR T-cells currently takes at least 4 weeks, they are not products which could be quickly employed initially at relapse in rapidly progressing mature B-cell malignancies but only for the consolidation phase of the treatment. Global, industry-supported, academic-sponsored studies testing compounds from different pharmaceutical companies simultaneously should be considered in rare populations, and it was proposed that an international working group be formed to develop an overarching clinical trials strategy for these disease groups. Future Forums are planned for other relevant paediatric oncologic diseases with a high unmet medical need and relevant molecular targets.
The present study documents an experimental and numerical investigation into the feasibility of g... more The present study documents an experimental and numerical investigation into the feasibility of generating longitudinal and transverse vortices in low speed wind tunnels. The longitudinal vortex system is that of a co-rotating vortex pair which, if substituted for a classical single tip vortex, may produce a beneficial modification to Blade Vortex Interaction. The transverse vortex mimics the tip vortex of a typical helicopter rotor and may be used to assess its effect when interacting with other aerofoils or fuselage components. Experiments have been conducted to investigate the flow field associated with two co-rotating vortices which represent the idealised vortex system associated with a novel rotor blade tip platform - the Westland Helicopters Vane Tip. These vortices were generated by two rectangular NACA 0015 half wings positioned upstream of the working section of a low speed wind tunnel. Hot-wire measurements were conducted downstream of the generators using x-wire probes t...