Cristina Campoy | University of Granada (original) (raw)

Papers by Cristina Campoy

Research paper thumbnail of Introduction of the New Associate Editor of Annals of Nutrition and Metabolism

Annals of Nutrition and Metabolism, 2012

Satoru Nagata is Head of the Department of Paediatrics and Neonatology, Juntendo University Schoo... more Satoru Nagata is Head of the Department of Paediatrics and Neonatology, Juntendo University School of Medicine, Shizuoka Hospital and Associate Professor of the Division for Probiotics Research, Juntendo University Postgraduate School, Tokyo, Japan. He received his MD at Juntendo University in 1987 and was awarded his PhD at Juntendo University Postgraduate School in 1993. He also graduated from the postgraduate course at the Department of Paediatric Gastroenterology, St. Bartholomew’s Hospital, London, in 1998. He is currently an instructor for both the Japanese Society for Parenteral and Enteral Nutrition and the Japanese Society for Neonatal Nutrition. His research focuses not only on nutrition in childhood, but also on treatment challenges for elderly patients and on how metabolism is affected by the intestinal microflora. Published online: June 1, 2012

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Research paper thumbnail of Implementing a complex mHealth coaching intervention to prevent overweight, obesity and diabetes in high-risk women in antenatal care: an implementation protocol (Preprint)

JMIR Research Protocols

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Research paper thumbnail of A Complex mHealth Coaching Intervention to Prevent Overweight, Obesity, and Diabetes in High-Risk Women in Antenatal Care: Protocol for a Hybrid Type 2 Effectiveness-Implementation Study (Preprint)

BACKGROUND Women with overweight and obesity are at higher risk of developing complications in pr... more BACKGROUND Women with overweight and obesity are at higher risk of developing complications in pregnancy such as gestational diabetes and longer-term chronic conditions. Research concerning health behavior change interventions during pregnancy and postpartum shows promising effects, but implementation into routine services is sparsely investigated. Most interventions focus on the antenatal or postpartum life stages, failing to meet the needs of women. IMPACT DIABETES Bump2Baby is a multicenter project across 4 high-income countries developed to test the implementation of an antenatal and postpartum evidence-based mobile health (mHealth) coaching intervention called Bump2Baby and Me (B2B&Me) designed to sit alongside usual care in the perinatal period. OBJECTIVE We aim to explore the feasibility and implementation of the B2B&Me intervention and investigate the effectiveness of this intervention in women at risk of gestational diabetes. METHODS IMPACT DIABETES Bump2Baby is a hybrid ty...

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Research paper thumbnail of Bump2Baby and Me: protocol for a randomised trial of mHealth coaching for healthy gestational weight gain and improved postnatal outcomes in high-risk women and their children

Trials, 2021

Background Gestational diabetes (GDM) impacts 8–18% of pregnancies and greatly increases both mat... more Background Gestational diabetes (GDM) impacts 8–18% of pregnancies and greatly increases both maternal and child risk of developing non-communicable diseases such as type 2 diabetes and obesity. Whilst lifestyle interventions in pregnancy and postpartum reduce this risk, a research translation gap remains around delivering implementable interventions with adequate population penetration and participation. Impact Diabetes Bump2Baby is an implementation project of an evidence-based system of care for the prevention of overweight and obesity. Bump2Baby and Me is the multicentre randomised controlled trial investigating the effectiveness of a mHealth coaching programme in pregnancy and postpartum for women at high risk of developing GDM. Methods Eight hundred women will be recruited in early pregnancy from 4 clinical sites within Ireland, the UK, Spain, and Australia. Women will be screened for eligibility using the validated Monash GDM screening tool. Participants will be enrolled from...

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Research paper thumbnail of Valoración del cambio de composición corporal en adolescentes con sobrepeso y obesidad incluidos en un tratamiento multidisciplinar: Estudio EVASYON

Revista Española de Nutrición Humana y Dietética, 2018

La adolescencia se considera una etapa vulnerable desde el punto de vista nutricional, por la gra... more La adolescencia se considera una etapa vulnerable desde el punto de vista nutricional, por la gran demanda de nutrientes, las modificaciones en el estilo de vida y habitos dieteticos y los cambios psicosociales propios de esta etapa. La obesidad en la infancia y adolescencia se considera una enfermedad compleja, que preocupa tanto a padres como a profesionales sanitaros debido a su alta prevalencia, sus consecuencias en la edad adulta y su elevada morbimortalidad asociada. Los objetivos generales de la tesis son: 1) revisar la informacion disponible de los efectos en la grasa corporal del tratamiento del sobrepeso y/obesidad en ninos y adolescentes y obtener una mejor comprension de las tecnicas empleadas para detectar los cambios longitudinales, 2) valorar los indices antropometricos sencillos como predictores de los cambios de grasa corporal, empleando absorciometria dual de rayos X como metodo de referencia, 3) identificar los predictores cognitivos y conductuales del abandono de...

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Research paper thumbnail of SARS-CoV-2 RNA and antibody detection in human milk from a prospective multicenter study in Spain

BackgroundDuring the COVID-19 pandemic in 2020, breastfeeding in women positive for SARS-CoV-2 wa... more BackgroundDuring the COVID-19 pandemic in 2020, breastfeeding in women positive for SARS-CoV-2 was compromised due to contradictory data regarding potential viral transmission. However, growing evidence confirms the relevant role of breast milk in providing passive immunity by generating and transmitting specific antibodies against the virus. Thus, our study aimed to develop and validate a specific protocol to detect SARS-CoV-2 in breast milk matrix as well as to determine the impact of maternal SARS-CoV-2 infection on presence, concentration, and persistence of specific SARS-CoV-2 antibodies.Study design/MethodsA prospective multicenter longitudinal study in Spain was carried out from April to December 2020. A total of 60 mothers with SARS-CoV-2 infection and/or recovered from COVID-19 were included (n=52 PCR-diagnosed and n=8 seropositive). Data from maternal-infant clinical records and symptomatology were collected. A specific protocol was validated to detect SARS-CoV-2 RNA in br...

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Research paper thumbnail of Influence of maternal metabolic condition during pregnancy on offspring body composition at 6.5 years. preobe study

Clinical Nutrition, 2018

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Research paper thumbnail of Should formula for infants provide arachidonic acid along with DHA? A position paper of the European Academy of Paediatrics and the Child Health Foundation

The American Journal of Clinical Nutrition, 2019

Recently adopted regulatory standards on infant and follow-on formula for the European Union stip... more Recently adopted regulatory standards on infant and follow-on formula for the European Union stipulate that from February 2020 onwards, all such products marketed in the European Union must contain 20–50 mg omega-3 DHA (22:6n–3) per 100 kcal, which is equivalent to about 0.5–1% of fatty acids (FAs) and thus higher than typically found in human milk and current infant formula products, without the need to also include ω-6 arachidonic acid (AA; 20:4n–6). This novel concept of infant formula composition has given rise to concern and controversy because there is no accountable evidence on its suitability and safety in healthy infants. Therefore, international experts in the field of infant nutrition were invited to review the state of scientific research on DHA and AA, and to discuss the questions arising from the new European regulatory standards. Based on the available information, we recommend that infant and follow-on formula should provide both DHA and AA. The DHA should equal at l...

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Research paper thumbnail of SUN-PO292: Breastfeeding Promotes a Healthier Fatty Acid Composition in the Offspring Compared to Artificial and Mixed Feeding: The Preobe Study

Clinical Nutrition, 2019

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Research paper thumbnail of SUN-PO291: Breast Milk Fatty Acids Influence Infant Growth and Cognition: The Preobe Study

Clinical Nutrition, 2019

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Research paper thumbnail of Impact of maternal BMI and gestational diabetes mellitus on maternal and cord blood metabolome: results from the PREOBE cohort study

Acta Diabetologica, 2019

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Research paper thumbnail of TLR2, TLR4 und CD14 sind höher exprimiert im Nabelschnurblut und mütterlichem Blut Spanischer Mütter im Vergleich zu Deutschen Müttern

Aktuelle Ernährungsmedizin, 2004

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Research paper thumbnail of Systematic Review on N-3 and N-6 Polyunsaturated Fatty Acid Intake in European Countries in Light of the Current Recommendations - Focus on Specific Population Groups

Annals of Nutrition and Metabolism, 2017

Background: Earlier reviews indicated that in many countries adults, children and adolescents con... more Background: Earlier reviews indicated that in many countries adults, children and adolescents consume on an average less polyunsaturated fatty acids (PUFAs) than recommended by the Food and Agriculture Organisation/World Health Organisation. Summary: The intake of total and individual n-3 and n-6 PUFAs in European infants, children, adolescents, elderly and pregnant/lactating women was evaluated systematically. Results: The evaluations were done against recommendations of the European Food Safety Authority. Key Messages: Fifty-three studies from 17 different European countries reported an intake of total n-3 and n-6 PUFAs and/or individual n-3 or n-6 PUFAs in at least one of the specific population groups: 10 in pregnant women, 4 in lactating women, 3 in infants 6-12 months, 6 in children 1-3 years, 11 in children 4-9 years, 8 in adolescents 10-18 years and 11 in elderly >65 years. Mean linoleic acid intake was within the recommendation (4 energy percentage [E%]) in 52% of the co...

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Research paper thumbnail of MON-LB275: Pre-Pregnancy Body Mass Index and Gestational Diabetes on Maternal Fatty Acid Profile and Placental Transfer

Clinical Nutrition, 2016

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Research paper thumbnail of Maternal Body Weight and Gestational Diabetes Differentially Influence Placental and Pregnancy Outcomes

The Journal of Clinical Endocrinology & Metabolism, 2016

Context:Maternal obesity and gestational diabetes mellitus (GDM) can both contribute to adverse n... more Context:Maternal obesity and gestational diabetes mellitus (GDM) can both contribute to adverse neonatal outcomes. The extent to which this may be mediated by differences in placental metabolism and nutrient transport remains to be determined.Objective:Our objective was to examine whether raised maternal body mass index (BMI) and/or GDM contributed to a resetting of the expression of genes within the placenta that are involved in energy sensing, oxidative stress, inflammation, and metabolic pathways.Methods:Pregnant women from Spain were recruited as part of the “Study of Maternal Nutrition and Genetics on the Foetal Adiposity Programming” survey at the first antenatal visit (12–20 weeks of gestation) and stratified according to prepregnancy BMI and the incidence of GDM. At delivery, placenta and cord blood were sampled and newborn anthropometry measured.Results:Obese women with GDM had higher estimated fetal weight at 34 gestational weeks and a greater risk of preterm deliveries an...

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Research paper thumbnail of Fatty acid composition of plasma and erythrocytes in term infants fed human milk and formulae with and without docosahexaenoic and arachidonic acids from egg yolk lecithin

Early Human Development, 1998

Human milk contains small but nutritionally significant amounts of long-chain polyunsaturated fat... more Human milk contains small but nutritionally significant amounts of long-chain polyunsaturated fatty acids (LCP), such as arachidonic (AA, 20:4n-6) and docosahexaenoic (DHA, 22:6n-3) acids, which are not present in most infant formulae. In the present study, the fatty acid composition of plasma and erythrocytes was determined at birth and again at 7 days, 1 and 3 months in 49 healthy

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Research paper thumbnail of ESPGHAN Committee on Nutrition Position Paper. Intravenous Lipid Emulsions and Risk of Hepatotoxicity in Infants and Children

Journal of Pediatric Gastroenterology & Nutrition, 2016

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Research paper thumbnail of The Effect of Maternal Obesity on Breast Milk Fatty Acids and Its Association with Infant Growth and Cognition—The PREOBE Follow-Up

Nutrients, 2019

This study analyzed how maternal obesity affected fatty acids (FAs) in breast milk and their asso... more This study analyzed how maternal obesity affected fatty acids (FAs) in breast milk and their association with infant growth and cognition to raise awareness about the programming effect of maternal health and to promote a healthy prenatal weight. Mother–child pairs (n = 78) were grouped per maternal pre-pregnancy body mass index (BMI): normal-weight (BMI = 18.5–24.99), overweight (BMI = 25–29.99) and obese (BMI > 30). Colostrum and mature milk FAs were determined. Infant anthropometry at 6, 18 and 36 months of age and cognition at 18 were analyzed. Mature milk exhibited lower arachidonic acid (AA) and docosahexaenoic acid (DHA), among others, than colostrum. Breast milk of non-normal weight mothers presented increased saturated FAs and n6:n3 ratio and decreased α-linolenic acid (ALA), DHA and monounsaturated FAs. Infant BMI-for-age at 6 months of age was inversely associated with colostrum n6 (e.g., AA) and n3 (e.g., DHA) FAs and positively associated with n6:n3 ratio. Depending ...

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Research paper thumbnail of Contents Vol. 60, 2012

Annals of Nutrition and Metabolism, 2012

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Research paper thumbnail of Impact of Total Parenteral Nutrition on Gut Microbiota in Pediatric Population Suffering Intestinal Disorders

Nutrients

Parenteral nutrition (PN) is a life-saving therapy providing nutritional support in patients with... more Parenteral nutrition (PN) is a life-saving therapy providing nutritional support in patients with digestive tract complications, particularly in preterm neonates due to their gut immaturity during the first postnatal weeks. Despite this, PN can also result in several gastrointestinal complications that are the cause or consequence of gut mucosal atrophy and gut microbiota dysbiosis, which may further aggravate gastrointestinal disorders. Consequently, the use of PN presents many unique challenges, notably in terms of the potential role of the gut microbiota on the functional and clinical outcomes associated with the long-term use of PN. In this review, we synthesize the current evidence on the effects of PN on gut microbiome in infants and children suffering from diverse gastrointestinal diseases, including necrotizing enterocolitis (NEC), short bowel syndrome (SBS) and subsequent intestinal failure, liver disease and inflammatory bowel disease (IBD). Moreover, we discuss the potent...

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Research paper thumbnail of Introduction of the New Associate Editor of Annals of Nutrition and Metabolism

Annals of Nutrition and Metabolism, 2012

Satoru Nagata is Head of the Department of Paediatrics and Neonatology, Juntendo University Schoo... more Satoru Nagata is Head of the Department of Paediatrics and Neonatology, Juntendo University School of Medicine, Shizuoka Hospital and Associate Professor of the Division for Probiotics Research, Juntendo University Postgraduate School, Tokyo, Japan. He received his MD at Juntendo University in 1987 and was awarded his PhD at Juntendo University Postgraduate School in 1993. He also graduated from the postgraduate course at the Department of Paediatric Gastroenterology, St. Bartholomew’s Hospital, London, in 1998. He is currently an instructor for both the Japanese Society for Parenteral and Enteral Nutrition and the Japanese Society for Neonatal Nutrition. His research focuses not only on nutrition in childhood, but also on treatment challenges for elderly patients and on how metabolism is affected by the intestinal microflora. Published online: June 1, 2012

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Research paper thumbnail of Implementing a complex mHealth coaching intervention to prevent overweight, obesity and diabetes in high-risk women in antenatal care: an implementation protocol (Preprint)

JMIR Research Protocols

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Research paper thumbnail of A Complex mHealth Coaching Intervention to Prevent Overweight, Obesity, and Diabetes in High-Risk Women in Antenatal Care: Protocol for a Hybrid Type 2 Effectiveness-Implementation Study (Preprint)

BACKGROUND Women with overweight and obesity are at higher risk of developing complications in pr... more BACKGROUND Women with overweight and obesity are at higher risk of developing complications in pregnancy such as gestational diabetes and longer-term chronic conditions. Research concerning health behavior change interventions during pregnancy and postpartum shows promising effects, but implementation into routine services is sparsely investigated. Most interventions focus on the antenatal or postpartum life stages, failing to meet the needs of women. IMPACT DIABETES Bump2Baby is a multicenter project across 4 high-income countries developed to test the implementation of an antenatal and postpartum evidence-based mobile health (mHealth) coaching intervention called Bump2Baby and Me (B2B&Me) designed to sit alongside usual care in the perinatal period. OBJECTIVE We aim to explore the feasibility and implementation of the B2B&Me intervention and investigate the effectiveness of this intervention in women at risk of gestational diabetes. METHODS IMPACT DIABETES Bump2Baby is a hybrid ty...

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Research paper thumbnail of Bump2Baby and Me: protocol for a randomised trial of mHealth coaching for healthy gestational weight gain and improved postnatal outcomes in high-risk women and their children

Trials, 2021

Background Gestational diabetes (GDM) impacts 8–18% of pregnancies and greatly increases both mat... more Background Gestational diabetes (GDM) impacts 8–18% of pregnancies and greatly increases both maternal and child risk of developing non-communicable diseases such as type 2 diabetes and obesity. Whilst lifestyle interventions in pregnancy and postpartum reduce this risk, a research translation gap remains around delivering implementable interventions with adequate population penetration and participation. Impact Diabetes Bump2Baby is an implementation project of an evidence-based system of care for the prevention of overweight and obesity. Bump2Baby and Me is the multicentre randomised controlled trial investigating the effectiveness of a mHealth coaching programme in pregnancy and postpartum for women at high risk of developing GDM. Methods Eight hundred women will be recruited in early pregnancy from 4 clinical sites within Ireland, the UK, Spain, and Australia. Women will be screened for eligibility using the validated Monash GDM screening tool. Participants will be enrolled from...

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Research paper thumbnail of Valoración del cambio de composición corporal en adolescentes con sobrepeso y obesidad incluidos en un tratamiento multidisciplinar: Estudio EVASYON

Revista Española de Nutrición Humana y Dietética, 2018

La adolescencia se considera una etapa vulnerable desde el punto de vista nutricional, por la gra... more La adolescencia se considera una etapa vulnerable desde el punto de vista nutricional, por la gran demanda de nutrientes, las modificaciones en el estilo de vida y habitos dieteticos y los cambios psicosociales propios de esta etapa. La obesidad en la infancia y adolescencia se considera una enfermedad compleja, que preocupa tanto a padres como a profesionales sanitaros debido a su alta prevalencia, sus consecuencias en la edad adulta y su elevada morbimortalidad asociada. Los objetivos generales de la tesis son: 1) revisar la informacion disponible de los efectos en la grasa corporal del tratamiento del sobrepeso y/obesidad en ninos y adolescentes y obtener una mejor comprension de las tecnicas empleadas para detectar los cambios longitudinales, 2) valorar los indices antropometricos sencillos como predictores de los cambios de grasa corporal, empleando absorciometria dual de rayos X como metodo de referencia, 3) identificar los predictores cognitivos y conductuales del abandono de...

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Research paper thumbnail of SARS-CoV-2 RNA and antibody detection in human milk from a prospective multicenter study in Spain

BackgroundDuring the COVID-19 pandemic in 2020, breastfeeding in women positive for SARS-CoV-2 wa... more BackgroundDuring the COVID-19 pandemic in 2020, breastfeeding in women positive for SARS-CoV-2 was compromised due to contradictory data regarding potential viral transmission. However, growing evidence confirms the relevant role of breast milk in providing passive immunity by generating and transmitting specific antibodies against the virus. Thus, our study aimed to develop and validate a specific protocol to detect SARS-CoV-2 in breast milk matrix as well as to determine the impact of maternal SARS-CoV-2 infection on presence, concentration, and persistence of specific SARS-CoV-2 antibodies.Study design/MethodsA prospective multicenter longitudinal study in Spain was carried out from April to December 2020. A total of 60 mothers with SARS-CoV-2 infection and/or recovered from COVID-19 were included (n=52 PCR-diagnosed and n=8 seropositive). Data from maternal-infant clinical records and symptomatology were collected. A specific protocol was validated to detect SARS-CoV-2 RNA in br...

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Research paper thumbnail of Influence of maternal metabolic condition during pregnancy on offspring body composition at 6.5 years. preobe study

Clinical Nutrition, 2018

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Research paper thumbnail of Should formula for infants provide arachidonic acid along with DHA? A position paper of the European Academy of Paediatrics and the Child Health Foundation

The American Journal of Clinical Nutrition, 2019

Recently adopted regulatory standards on infant and follow-on formula for the European Union stip... more Recently adopted regulatory standards on infant and follow-on formula for the European Union stipulate that from February 2020 onwards, all such products marketed in the European Union must contain 20–50 mg omega-3 DHA (22:6n–3) per 100 kcal, which is equivalent to about 0.5–1% of fatty acids (FAs) and thus higher than typically found in human milk and current infant formula products, without the need to also include ω-6 arachidonic acid (AA; 20:4n–6). This novel concept of infant formula composition has given rise to concern and controversy because there is no accountable evidence on its suitability and safety in healthy infants. Therefore, international experts in the field of infant nutrition were invited to review the state of scientific research on DHA and AA, and to discuss the questions arising from the new European regulatory standards. Based on the available information, we recommend that infant and follow-on formula should provide both DHA and AA. The DHA should equal at l...

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Research paper thumbnail of SUN-PO292: Breastfeeding Promotes a Healthier Fatty Acid Composition in the Offspring Compared to Artificial and Mixed Feeding: The Preobe Study

Clinical Nutrition, 2019

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Research paper thumbnail of SUN-PO291: Breast Milk Fatty Acids Influence Infant Growth and Cognition: The Preobe Study

Clinical Nutrition, 2019

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Research paper thumbnail of Impact of maternal BMI and gestational diabetes mellitus on maternal and cord blood metabolome: results from the PREOBE cohort study

Acta Diabetologica, 2019

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Research paper thumbnail of TLR2, TLR4 und CD14 sind höher exprimiert im Nabelschnurblut und mütterlichem Blut Spanischer Mütter im Vergleich zu Deutschen Müttern

Aktuelle Ernährungsmedizin, 2004

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Research paper thumbnail of Systematic Review on N-3 and N-6 Polyunsaturated Fatty Acid Intake in European Countries in Light of the Current Recommendations - Focus on Specific Population Groups

Annals of Nutrition and Metabolism, 2017

Background: Earlier reviews indicated that in many countries adults, children and adolescents con... more Background: Earlier reviews indicated that in many countries adults, children and adolescents consume on an average less polyunsaturated fatty acids (PUFAs) than recommended by the Food and Agriculture Organisation/World Health Organisation. Summary: The intake of total and individual n-3 and n-6 PUFAs in European infants, children, adolescents, elderly and pregnant/lactating women was evaluated systematically. Results: The evaluations were done against recommendations of the European Food Safety Authority. Key Messages: Fifty-three studies from 17 different European countries reported an intake of total n-3 and n-6 PUFAs and/or individual n-3 or n-6 PUFAs in at least one of the specific population groups: 10 in pregnant women, 4 in lactating women, 3 in infants 6-12 months, 6 in children 1-3 years, 11 in children 4-9 years, 8 in adolescents 10-18 years and 11 in elderly >65 years. Mean linoleic acid intake was within the recommendation (4 energy percentage [E%]) in 52% of the co...

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Research paper thumbnail of MON-LB275: Pre-Pregnancy Body Mass Index and Gestational Diabetes on Maternal Fatty Acid Profile and Placental Transfer

Clinical Nutrition, 2016

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Research paper thumbnail of Maternal Body Weight and Gestational Diabetes Differentially Influence Placental and Pregnancy Outcomes

The Journal of Clinical Endocrinology & Metabolism, 2016

Context:Maternal obesity and gestational diabetes mellitus (GDM) can both contribute to adverse n... more Context:Maternal obesity and gestational diabetes mellitus (GDM) can both contribute to adverse neonatal outcomes. The extent to which this may be mediated by differences in placental metabolism and nutrient transport remains to be determined.Objective:Our objective was to examine whether raised maternal body mass index (BMI) and/or GDM contributed to a resetting of the expression of genes within the placenta that are involved in energy sensing, oxidative stress, inflammation, and metabolic pathways.Methods:Pregnant women from Spain were recruited as part of the “Study of Maternal Nutrition and Genetics on the Foetal Adiposity Programming” survey at the first antenatal visit (12–20 weeks of gestation) and stratified according to prepregnancy BMI and the incidence of GDM. At delivery, placenta and cord blood were sampled and newborn anthropometry measured.Results:Obese women with GDM had higher estimated fetal weight at 34 gestational weeks and a greater risk of preterm deliveries an...

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Research paper thumbnail of Fatty acid composition of plasma and erythrocytes in term infants fed human milk and formulae with and without docosahexaenoic and arachidonic acids from egg yolk lecithin

Early Human Development, 1998

Human milk contains small but nutritionally significant amounts of long-chain polyunsaturated fat... more Human milk contains small but nutritionally significant amounts of long-chain polyunsaturated fatty acids (LCP), such as arachidonic (AA, 20:4n-6) and docosahexaenoic (DHA, 22:6n-3) acids, which are not present in most infant formulae. In the present study, the fatty acid composition of plasma and erythrocytes was determined at birth and again at 7 days, 1 and 3 months in 49 healthy

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Research paper thumbnail of ESPGHAN Committee on Nutrition Position Paper. Intravenous Lipid Emulsions and Risk of Hepatotoxicity in Infants and Children

Journal of Pediatric Gastroenterology & Nutrition, 2016

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Research paper thumbnail of The Effect of Maternal Obesity on Breast Milk Fatty Acids and Its Association with Infant Growth and Cognition—The PREOBE Follow-Up

Nutrients, 2019

This study analyzed how maternal obesity affected fatty acids (FAs) in breast milk and their asso... more This study analyzed how maternal obesity affected fatty acids (FAs) in breast milk and their association with infant growth and cognition to raise awareness about the programming effect of maternal health and to promote a healthy prenatal weight. Mother–child pairs (n = 78) were grouped per maternal pre-pregnancy body mass index (BMI): normal-weight (BMI = 18.5–24.99), overweight (BMI = 25–29.99) and obese (BMI > 30). Colostrum and mature milk FAs were determined. Infant anthropometry at 6, 18 and 36 months of age and cognition at 18 were analyzed. Mature milk exhibited lower arachidonic acid (AA) and docosahexaenoic acid (DHA), among others, than colostrum. Breast milk of non-normal weight mothers presented increased saturated FAs and n6:n3 ratio and decreased α-linolenic acid (ALA), DHA and monounsaturated FAs. Infant BMI-for-age at 6 months of age was inversely associated with colostrum n6 (e.g., AA) and n3 (e.g., DHA) FAs and positively associated with n6:n3 ratio. Depending ...

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Research paper thumbnail of Contents Vol. 60, 2012

Annals of Nutrition and Metabolism, 2012

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Research paper thumbnail of Impact of Total Parenteral Nutrition on Gut Microbiota in Pediatric Population Suffering Intestinal Disorders

Nutrients

Parenteral nutrition (PN) is a life-saving therapy providing nutritional support in patients with... more Parenteral nutrition (PN) is a life-saving therapy providing nutritional support in patients with digestive tract complications, particularly in preterm neonates due to their gut immaturity during the first postnatal weeks. Despite this, PN can also result in several gastrointestinal complications that are the cause or consequence of gut mucosal atrophy and gut microbiota dysbiosis, which may further aggravate gastrointestinal disorders. Consequently, the use of PN presents many unique challenges, notably in terms of the potential role of the gut microbiota on the functional and clinical outcomes associated with the long-term use of PN. In this review, we synthesize the current evidence on the effects of PN on gut microbiome in infants and children suffering from diverse gastrointestinal diseases, including necrotizing enterocolitis (NEC), short bowel syndrome (SBS) and subsequent intestinal failure, liver disease and inflammatory bowel disease (IBD). Moreover, we discuss the potent...

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