j loo | Georgia State University (original) (raw)

Address: Smyrna, Georgia, United States

less

Uploads

Papers by j loo

Research paper thumbnail of Six new loci associated with body mass index highlight a neuronal influence on body weight regulation

Research paper thumbnail of Ficoll-isopaque gradients for the determination of density distributions of human blood lymphocytes and other reticulo-endothelial cells*1

Experimental Cell Research, 1974

Research paper thumbnail of Abstract

Annals of Hematology, 1992

Research paper thumbnail of Biological, clinical and population relevance of 95 loci for blood lipids

Nature, 2010

Plasma concentrations of total cholesterol, low-density lipoprotein cholesterol, high-density lip... more Plasma concentrations of total cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol and triglycerides are among the most important risk factors for coronary artery disease (CAD) and are targets for therapeutic intervention. We screened the genome for common variants associated with plasma lipids in >100,000 individuals of European ancestry. Here we report 95 significantly associated loci (P<5×10-8), with 59 showing genome-wide significant association with lipid traits for the first time. The newly reported associations include single nucleotide polymorphisms (SNPs) near known lipid regulators (for example, CYP7A1, NPC1L1 and SCARB1) as well as in scores of loci not previously implicated in lipoprotein metabolism. The 95 loci contribute not only to normal variation in lipid traits but also to extreme lipid phenotypes and have an impact on lipid traits in three non-European populations (East Asians, South Asians and African Americans). Our results identify several novel loci associated with plasma lipids that are also associated with CAD. Finally, we validated three of the novel genes-GALNT2, PPP1R3B and TTC39B-with experiments in mouse models. Taken together, our findings provide the foundation to develop a broader biological understanding of lipoprotein metabolism and to identify new therapeutic opportunities for the prevention of CAD.

Research paper thumbnail of Effects of St. John's wort on irinotecan metabolism

Journal of The National Cancer Institute, 2002

Research paper thumbnail of IL32, a proinflammatory cytokine in rheumatoid arthritis

Proceedings of The National Academy of Sciences, 2006

Research paper thumbnail of Ultrasonically guided transperineal seed implantation of the prostate: Modification of the technique and qualitative assessment of implants

International Journal of Radiation Oncology Biology Physics, 1992

Research paper thumbnail of Genome-wide association analysis identifies 20 loci that influence adult height

Research paper thumbnail of New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk

Research paper thumbnail of Cremophor EL-mediated alteration of paclitaxel distribution in human blood: clinical pharmacokinetic implications

Research paper thumbnail of Six new loci associated with body mass index highlight a neuronal influence on body weight regulation

Research paper thumbnail of Ficoll-isopaque gradients for the determination of density distributions of human blood lymphocytes and other reticulo-endothelial cells*1

Experimental Cell Research, 1974

Research paper thumbnail of Abstract

Annals of Hematology, 1992

Research paper thumbnail of Biological, clinical and population relevance of 95 loci for blood lipids

Nature, 2010

Plasma concentrations of total cholesterol, low-density lipoprotein cholesterol, high-density lip... more Plasma concentrations of total cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol and triglycerides are among the most important risk factors for coronary artery disease (CAD) and are targets for therapeutic intervention. We screened the genome for common variants associated with plasma lipids in >100,000 individuals of European ancestry. Here we report 95 significantly associated loci (P<5×10-8), with 59 showing genome-wide significant association with lipid traits for the first time. The newly reported associations include single nucleotide polymorphisms (SNPs) near known lipid regulators (for example, CYP7A1, NPC1L1 and SCARB1) as well as in scores of loci not previously implicated in lipoprotein metabolism. The 95 loci contribute not only to normal variation in lipid traits but also to extreme lipid phenotypes and have an impact on lipid traits in three non-European populations (East Asians, South Asians and African Americans). Our results identify several novel loci associated with plasma lipids that are also associated with CAD. Finally, we validated three of the novel genes-GALNT2, PPP1R3B and TTC39B-with experiments in mouse models. Taken together, our findings provide the foundation to develop a broader biological understanding of lipoprotein metabolism and to identify new therapeutic opportunities for the prevention of CAD.

Research paper thumbnail of Effects of St. John's wort on irinotecan metabolism

Journal of The National Cancer Institute, 2002

Research paper thumbnail of IL32, a proinflammatory cytokine in rheumatoid arthritis

Proceedings of The National Academy of Sciences, 2006

Research paper thumbnail of Ultrasonically guided transperineal seed implantation of the prostate: Modification of the technique and qualitative assessment of implants

International Journal of Radiation Oncology Biology Physics, 1992

Research paper thumbnail of Genome-wide association analysis identifies 20 loci that influence adult height

Research paper thumbnail of New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk

Research paper thumbnail of Cremophor EL-mediated alteration of paclitaxel distribution in human blood: clinical pharmacokinetic implications

Log In