Ajay Suthar | Gujarat Technological University (original) (raw)
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Papers by Ajay Suthar
In recent years, silica aerogels have attracted more and more attention due to their surprising p... more In recent years, silica aerogels have attracted more and more attention due to their surprising properties and their existing and potential applications in wide variety technological areas. Silica aerogel is a nanostructured material with high specific surface area, high porosity, low dielectric constant, low density and outstanding heat insulation properties. Release of some active ingredients from the aerogel-drug formulation is
The goal of this project is to formulate dispersible tablet of Cefditoren Pivoxil (CP) that is in... more The goal of this project is to formulate dispersible tablet of Cefditoren Pivoxil (CP) that is intended to disintegrate
rapidly into the water and form a stabilized dispersion. A direct compression method was failed to formulate
dispersible tablet of CP so wet granulation method was used. In preliminary study different superdisintegrant
croscarmellose sodium (CCS), sodium starch glycolate (SSG) and crospovidone were evaluated for weight variation,
content uniformity, hardness, disintegration time, and friability of tablets. Microcrystalline cellulose:low‐substituted
hydroxypropyl cellulose ratio was optimized 8:2 in whole experiment as it gives minimum disintegration time. Full
factorial designs 32 was used to optimize concentration of superdisintegrant (X1) and SLS (X2) which were selected as
independent variables, and friability, disintegration time and % CDR was selected as dependent variable. From
response surface plot of disintegration time, % drug release after 15 minis (Q15) and friability it was found that lower
disintegration time of tablets could be obtained when X1 and X2 are kept at optimum level. Stability study of final batch
showed no significant changes in tablet properties.
Fluidized hot-melt granulation (FHMG) is a nonambient process that results in the phase transitio... more Fluidized hot-melt granulation (FHMG) is a nonambient process that results in the phase transition of a solid-state binder in situ. These binders are used to prepare pharmaceutical granules having a suitable size and compression profile for processing with fluid-bed granulation. Melt granulation facilitates the manufacture of various dosage forms and formulations such as immediate and sustained-release pellets, granules, and tablets.
In recent years, silica aerogels have attracted more and more attention due to their surprising p... more In recent years, silica aerogels have attracted more and more attention due to their surprising properties and their existing and potential applications in wide variety technological areas. Silica aerogel is a nanostructured material with high specific surface area, high porosity, low dielectric constant, low density and outstanding heat insulation properties. Release of some active ingredients from the aerogel-drug formulation is
The goal of this project is to formulate dispersible tablet of Cefditoren Pivoxil (CP) that is in... more The goal of this project is to formulate dispersible tablet of Cefditoren Pivoxil (CP) that is intended to disintegrate
rapidly into the water and form a stabilized dispersion. A direct compression method was failed to formulate
dispersible tablet of CP so wet granulation method was used. In preliminary study different superdisintegrant
croscarmellose sodium (CCS), sodium starch glycolate (SSG) and crospovidone were evaluated for weight variation,
content uniformity, hardness, disintegration time, and friability of tablets. Microcrystalline cellulose:low‐substituted
hydroxypropyl cellulose ratio was optimized 8:2 in whole experiment as it gives minimum disintegration time. Full
factorial designs 32 was used to optimize concentration of superdisintegrant (X1) and SLS (X2) which were selected as
independent variables, and friability, disintegration time and % CDR was selected as dependent variable. From
response surface plot of disintegration time, % drug release after 15 minis (Q15) and friability it was found that lower
disintegration time of tablets could be obtained when X1 and X2 are kept at optimum level. Stability study of final batch
showed no significant changes in tablet properties.
Fluidized hot-melt granulation (FHMG) is a nonambient process that results in the phase transitio... more Fluidized hot-melt granulation (FHMG) is a nonambient process that results in the phase transition of a solid-state binder in situ. These binders are used to prepare pharmaceutical granules having a suitable size and compression profile for processing with fluid-bed granulation. Melt granulation facilitates the manufacture of various dosage forms and formulations such as immediate and sustained-release pellets, granules, and tablets.