Christopher Wesselman | The George Washington University (original) (raw)
Address: Washington, District of Columbia, United States
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Papers by Christopher Wesselman
Drug Metabolism and Pharmacokinetics, 2007
Pharmacogenetics and Genomics, 2008
Objectives Cytochrome P450 oxidoreductase (POR) is the only flavoprotein that donates electrons t... more Objectives Cytochrome P450 oxidoreductase (POR) is the only flavoprotein that donates electrons to all microsomal P450 enzymes, which catalyze the biosynthesis of steroids, fatty acids, and bile acids, as well as metabolism of more than 80% of prescription drugs. Although mutations in POR have been identified in several disease states with disordered steroidogenesis, effects of polymorphisms on drug metabolism in the general population are unclear. In this report, we performed a comprehensive study to correlate POR polymorphisms with POR gene expression, POR activity, and P450catalyzed drug metabolism.
Drug Metabolism and Pharmacokinetics, 2007
Pharmacogenetics and Genomics, 2008
Objectives Cytochrome P450 oxidoreductase (POR) is the only flavoprotein that donates electrons t... more Objectives Cytochrome P450 oxidoreductase (POR) is the only flavoprotein that donates electrons to all microsomal P450 enzymes, which catalyze the biosynthesis of steroids, fatty acids, and bile acids, as well as metabolism of more than 80% of prescription drugs. Although mutations in POR have been identified in several disease states with disordered steroidogenesis, effects of polymorphisms on drug metabolism in the general population are unclear. In this report, we performed a comprehensive study to correlate POR polymorphisms with POR gene expression, POR activity, and P450catalyzed drug metabolism.