Role of platelets in cancer and cancer-associated thrombosis: Experimental and clinical evidences. (original) (raw)

Soraya Mezouar (1, 2) , Corinne Frère (2, 1) , Roxane Darbousset (2, 1) , Diane Mege (2, 1, 3) , Lydie Crescence (2, 1) , Francoise Dignat-George (4, 1, 2) , Laurence Panicot-Dubois (2, 1) , Christophe Dubois (2, 1)

Résumé

The primary hemostatic function of platelets has been recognized for more than a century, but increasing experimental and clinical evidences suggest that platelets are also important mediators of cancer. Cancer indeed influences platelet physiology, and activated platelets participate in each step of cancer development by promoting tumor growth, angiogenesis, metastasis, and cancer-associated thrombosis. Based on both the results of numerous experimental models addressing the involvement of platelets in cancer progression and the results of epidemiologic studies on the use of anti-platelet drugs to prevent cancer, platelets have been proposed as a potential target to reduce the short-term risk of cancer, cancer dissemination and cancer mortality. However, the cancer-associated thrombosis and the risk of bleeding due to anti-platelet drugs are not enough evaluated in experimental models. Therefore, the interesting contribution of platelets to cancer and cancer-associated thrombosis requires the standardization of preclinical and clinical models.

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https://amu.hal.science/hal-01455290

Soumis le : jeudi 13 février 2020-16:38:36

Dernière modification le : jeudi 18 avril 2024-16:26:16

Archivage à long terme le : jeudi 14 mai 2020-16:25:19

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hal-01455290 , version 1 (13-02-2020)

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Soraya Mezouar, Corinne Frère, Roxane Darbousset, Diane Mege, Lydie Crescence, et al.. Role of platelets in cancer and cancer-associated thrombosis: Experimental and clinical evidences.. Thrombosis Research, 2016, 139, pp.65-76. ⟨10.1016/j.thromres.2016.01.006⟩. ⟨hal-01455290⟩

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