Nicolas Ramirez Garrido (Student) | Harvard University (original) (raw)

Uploads

Papers by Nicolas Ramirez Garrido (Student)

Research paper thumbnail of Individual luteolysis pattern after GnRH-agonist trigger for final oocyte maturation

PloS one, 2017

Final oocyte maturation using GnRH-agonist trigger in a GnRH-antagonist protocol is increasingly ... more Final oocyte maturation using GnRH-agonist trigger in a GnRH-antagonist protocol is increasingly common, as ovarian hyperstimulation syndrome is almost completely avoided. However, this approach might lead to reduced pregnancy rates due to severe luteolysis. This proof of concept study evaluated the extend of luteolysis by measuring progesterone levels 48 hours after oocyte retrieval in 51 patients, who received GnRH-agonist trigger for final oocyte maturation in a GnRH-antagonist protocol due to the risk of ovarian hyperstimulation syndrome. It was shown, that luteolysis after GnRHa-trigger differs greatly among patients, with progesterone levels ranging from 13.0 ng/ml to ≥ 60.0 ng/ml, 48 hours after oocyte retrieval. Significant positive correlations could be demonstrated between progesterone levels and the number of ovarian stimulation and suppression days (p = 0.006 and p = 0.002 respectively), the total amount of medication used for ovarian suppression (p = 0.015), the level o...

Research paper thumbnail of The Allocation of Surplus by Markets: A Framework for Analysis

International Journal of Modern Physics C, 2008

The aim of this paper is to present algorithmic specifications of institutions as an alternative ... more The aim of this paper is to present algorithmic specifications of institutions as an alternative to the pervasive gradient institutions used in mainstream economics. A framework to evaluate the performance of the institutions is proposed using instruments from landscape theory. The problem of how a simple market allocates surplus is studied as an example of application of the framework.

Research paper thumbnail of Session 32: Efficacy in ART

Research paper thumbnail of Reproductive outcome of testicular sperm extraction (TESE) in an ovum donation program; a good model to evaluate the retrieved sperm quality

Fertility and Sterility, 2007

Research paper thumbnail of The presence of uterine adenomyosis does not affect implantation in an oocyte donation program

Fertility and Sterility, 2008

In this first comparison of LBR between Indian and Caucasian women after BT, we found lower impla... more In this first comparison of LBR between Indian and Caucasian women after BT, we found lower implantation and LB rates in Indians. The cause for this difference remains unclear since the groups have similar response to stimulation and comparable embryo quality. The majority of our Indian patients were not born in the U.S. Studies are needed to evaluate ethnic differences in endometrial receptivity and environmental effects on fertility.

Research paper thumbnail of Human immunodeficiency type-1 virus (HIV-1) infection in serodiscordant couples (SDCs) does not have an impact on embryo quality or intracytoplasmic sperm …

Fertility and sterility, 2008

To evaluate the embryo quality in our program for human immunodeficiency type-1 virus (HIV-1) ser... more To evaluate the embryo quality in our program for human immunodeficiency type-1 virus (HIV-1) serodiscordant couples (SDCs) with the male infected in comparison with a tubal-factor infertility control group. ... Thirty SDC and 79 control couples without HIV-1 infection ...

Research paper thumbnail of Improvements Achieved In An Oocyte Donation Program Over a 10-Year Period: Sequential Increase In Implantation and Pregnancy Rates and Decrease In High-Order …

Fertility and sterility, 2007

Objective: To compare outcome parameters and cumulative pregnancy rates (PRs) in oocyte donation ... more Objective: To compare outcome parameters and cumulative pregnancy rates (PRs) in oocyte donation cycles over a period of 10 years. Design: Retrospective study. Setting: University-affiliated assisted reproductive technology program. Patient(s): Women undergoing oocyte donation (10,537 cycles) between 1995 and 2005. Intervention(s): Ovarian stimulation and oocyte retrieval in donors. Embryo transfer performed in recipients after endometrial preparation. Main Outcome Measure(s): Outcome parameters and cumulative PRs were calculated and compared in relation to indication, age, and origin of sperm used. Result(s): Overall PR, implantation rate, clinical PR, and miscarriage rate per embryo transfer performed were 54.9%, 27%, 50.3%, and 19%, respectively. Ongoing PR per transfer was 40.2%, and twin and high-order multiple PRs were 39% and 6%, respectively. Mean number of embryos transferred was reduced from 3.6 Ϯ 0.8 to 1.9 Ϯ 0.3, implantation rate improved from 16.7% to 38.3%, and ongoing PR improved from 31% to 44.3%. Cumulative PRs did not differ significantly among different indications for oocyte donation, age groups, or origin of sperm used for oocyte insemination. Overall cumulative PRs after three and five cycles were calculated as 87% and 96.8%, respectively. Conclusion(s): Significant improvements in outcome parameters were achieved within 10 years. Similar cumulative PRs were observed regardless of recipient age, indication for oocyte donation, or sperm origin.

Research paper thumbnail of Individual luteolysis pattern after GnRH-agonist trigger for final oocyte maturation

PloS one, 2017

Final oocyte maturation using GnRH-agonist trigger in a GnRH-antagonist protocol is increasingly ... more Final oocyte maturation using GnRH-agonist trigger in a GnRH-antagonist protocol is increasingly common, as ovarian hyperstimulation syndrome is almost completely avoided. However, this approach might lead to reduced pregnancy rates due to severe luteolysis. This proof of concept study evaluated the extend of luteolysis by measuring progesterone levels 48 hours after oocyte retrieval in 51 patients, who received GnRH-agonist trigger for final oocyte maturation in a GnRH-antagonist protocol due to the risk of ovarian hyperstimulation syndrome. It was shown, that luteolysis after GnRHa-trigger differs greatly among patients, with progesterone levels ranging from 13.0 ng/ml to ≥ 60.0 ng/ml, 48 hours after oocyte retrieval. Significant positive correlations could be demonstrated between progesterone levels and the number of ovarian stimulation and suppression days (p = 0.006 and p = 0.002 respectively), the total amount of medication used for ovarian suppression (p = 0.015), the level o...

Research paper thumbnail of The Allocation of Surplus by Markets: A Framework for Analysis

International Journal of Modern Physics C, 2008

The aim of this paper is to present algorithmic specifications of institutions as an alternative ... more The aim of this paper is to present algorithmic specifications of institutions as an alternative to the pervasive gradient institutions used in mainstream economics. A framework to evaluate the performance of the institutions is proposed using instruments from landscape theory. The problem of how a simple market allocates surplus is studied as an example of application of the framework.

Research paper thumbnail of Session 32: Efficacy in ART

Research paper thumbnail of Reproductive outcome of testicular sperm extraction (TESE) in an ovum donation program; a good model to evaluate the retrieved sperm quality

Fertility and Sterility, 2007

Research paper thumbnail of The presence of uterine adenomyosis does not affect implantation in an oocyte donation program

Fertility and Sterility, 2008

In this first comparison of LBR between Indian and Caucasian women after BT, we found lower impla... more In this first comparison of LBR between Indian and Caucasian women after BT, we found lower implantation and LB rates in Indians. The cause for this difference remains unclear since the groups have similar response to stimulation and comparable embryo quality. The majority of our Indian patients were not born in the U.S. Studies are needed to evaluate ethnic differences in endometrial receptivity and environmental effects on fertility.

Research paper thumbnail of Human immunodeficiency type-1 virus (HIV-1) infection in serodiscordant couples (SDCs) does not have an impact on embryo quality or intracytoplasmic sperm …

Fertility and sterility, 2008

To evaluate the embryo quality in our program for human immunodeficiency type-1 virus (HIV-1) ser... more To evaluate the embryo quality in our program for human immunodeficiency type-1 virus (HIV-1) serodiscordant couples (SDCs) with the male infected in comparison with a tubal-factor infertility control group. ... Thirty SDC and 79 control couples without HIV-1 infection ...

Research paper thumbnail of Improvements Achieved In An Oocyte Donation Program Over a 10-Year Period: Sequential Increase In Implantation and Pregnancy Rates and Decrease In High-Order …

Fertility and sterility, 2007

Objective: To compare outcome parameters and cumulative pregnancy rates (PRs) in oocyte donation ... more Objective: To compare outcome parameters and cumulative pregnancy rates (PRs) in oocyte donation cycles over a period of 10 years. Design: Retrospective study. Setting: University-affiliated assisted reproductive technology program. Patient(s): Women undergoing oocyte donation (10,537 cycles) between 1995 and 2005. Intervention(s): Ovarian stimulation and oocyte retrieval in donors. Embryo transfer performed in recipients after endometrial preparation. Main Outcome Measure(s): Outcome parameters and cumulative PRs were calculated and compared in relation to indication, age, and origin of sperm used. Result(s): Overall PR, implantation rate, clinical PR, and miscarriage rate per embryo transfer performed were 54.9%, 27%, 50.3%, and 19%, respectively. Ongoing PR per transfer was 40.2%, and twin and high-order multiple PRs were 39% and 6%, respectively. Mean number of embryos transferred was reduced from 3.6 Ϯ 0.8 to 1.9 Ϯ 0.3, implantation rate improved from 16.7% to 38.3%, and ongoing PR improved from 31% to 44.3%. Cumulative PRs did not differ significantly among different indications for oocyte donation, age groups, or origin of sperm used for oocyte insemination. Overall cumulative PRs after three and five cycles were calculated as 87% and 96.8%, respectively. Conclusion(s): Significant improvements in outcome parameters were achieved within 10 years. Similar cumulative PRs were observed regardless of recipient age, indication for oocyte donation, or sperm origin.