Sherwin Tan | Hwa Chong Institution (original) (raw)
Papers by Sherwin Tan
Advanced Functional Materials, Nov 29, 2023
Molecules, Jul 20, 2023
This article is an open access article distributed under the terms and conditions of the Creative... more This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY
Materials today advances, Jun 1, 2022
Bioactive Materials, Feb 1, 2022
Lignin is a versatile biomass that possesses many different desirable properties such as antioxid... more Lignin is a versatile biomass that possesses many different desirable properties such as antioxidant, antibacterial, anti-UV, and good biocompatibility. Natural lignin can be processed through several chemical processes. The processed lignin can be modified into functionalized lignin through chemical modifications to develop and enhance biomaterials. Thus, lignin is one of the prime candidate for various biomaterial applications such as drug and gene delivery, biosensors, bioimaging, 3D printing, tissue engineering, and dietary supplement additive. This review presents the potential of developing and utilizing lignin in the outlook of new and sustainable biomaterials. Thereafter, we also discuss on the challenges and outlook of utilizing lignin as a biomaterial. Peer review under responsibility of KeAi Communications Co., Ltd.
Advanced Healthcare Materials
In situ analysis of sweat biomarkers potentially provides non‐invasive lifestyle monitoring and e... more In situ analysis of sweat biomarkers potentially provides non‐invasive lifestyle monitoring and early diagnosis. Quantitative detection of sweat rate is crucial for thermoregulation and preventing heat injuries. Here, we report a skin‐attachable paper fluidic patch for in situ colorimetric sensing of multiple sweat markers (pH, glucose, lactate, uric acid) with concurrent sweat rate tracking. Two sets of fluidic patterns – multiplexed detection zones and a longitudinal sweat rate channel – are directly printed by an automated ink‐dispenser from a specially‐developed ceramic‐based ink. The ceramic ink thermal‐cures into an impervious barrier, confining sweat within the channels. The ceramic ink‐printed boundary achieves higher pattern resolution, prevents fluid leakage, attains pattern thermal stability, and resistant to organic solvents. The cellulose matrix of the detection zones is modified with nanoparticles to improve the colour‐homogeneity and sweat sensor sensitivity. The swea...
Molecules
The use of proteins as biomolecular templates to synthesize atomically precise metal nanoclusters... more The use of proteins as biomolecular templates to synthesize atomically precise metal nanoclusters has been gaining traction due to their appealing properties such as photoluminescence, good colloidal- and photostability and biocompatibility. The synergistic effect of using a protein scaffold and metal nanoclusters makes it especially attractive for biomedical applications. Unlike other reviews, we focus on proteins in general as the protective ligand for various metal nanoclusters and highlight their applications in the biomedical field. We first introduce the approaches and underlined principles in synthesizing protein-templated metal nanoclusters and summarize some of the typical proteins that have been used thus far. Afterwards, we highlight the key physicochemical properties and the characterization techniques commonly used for the size, structure and optical properties of protein-templated metal nanoclusters. We feature two case studies to illustrate the importance of combining...
Continuous and in situ detection of biomarkers in biofluids (e.g., sweat) can provide critical he... more Continuous and in situ detection of biomarkers in biofluids (e.g., sweat) can provide critical health data but is limited by biofluids accessibility. Here, we report a sensor design that enables in situ detection of solid-state biomarkers ubiquitously present on human skin. We deploy an ionic-electronic bilayer hydrogel to facilitate the sequential dissolution, diffusion and electrochemical reaction of solid-state analytes. We demonstrate continuous monitoring of water-soluble analytes (i.e., solid lactate) and water-insoluble analytes (i.e., solid cholesterol) with ultralow detection limits of 0.51 nmol cm-2 and 0.26 nmol cm-2, respectively. Additionally, the bilayer hydrogel electrochemical interface reduces motion artifacts by three times compared to conventional liquid-sensing electrochemical interfaces. In a clinical study, solid-state epidermal biomarkers measured by our stretchable wearable sensors showed a high correlation with biomarkers in human blood and dynamically corre...
Advanced Functional Materials, Nov 29, 2023
Molecules, Jul 20, 2023
This article is an open access article distributed under the terms and conditions of the Creative... more This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY
Materials today advances, Jun 1, 2022
Bioactive Materials, Feb 1, 2022
Lignin is a versatile biomass that possesses many different desirable properties such as antioxid... more Lignin is a versatile biomass that possesses many different desirable properties such as antioxidant, antibacterial, anti-UV, and good biocompatibility. Natural lignin can be processed through several chemical processes. The processed lignin can be modified into functionalized lignin through chemical modifications to develop and enhance biomaterials. Thus, lignin is one of the prime candidate for various biomaterial applications such as drug and gene delivery, biosensors, bioimaging, 3D printing, tissue engineering, and dietary supplement additive. This review presents the potential of developing and utilizing lignin in the outlook of new and sustainable biomaterials. Thereafter, we also discuss on the challenges and outlook of utilizing lignin as a biomaterial. Peer review under responsibility of KeAi Communications Co., Ltd.
Advanced Healthcare Materials
In situ analysis of sweat biomarkers potentially provides non‐invasive lifestyle monitoring and e... more In situ analysis of sweat biomarkers potentially provides non‐invasive lifestyle monitoring and early diagnosis. Quantitative detection of sweat rate is crucial for thermoregulation and preventing heat injuries. Here, we report a skin‐attachable paper fluidic patch for in situ colorimetric sensing of multiple sweat markers (pH, glucose, lactate, uric acid) with concurrent sweat rate tracking. Two sets of fluidic patterns – multiplexed detection zones and a longitudinal sweat rate channel – are directly printed by an automated ink‐dispenser from a specially‐developed ceramic‐based ink. The ceramic ink thermal‐cures into an impervious barrier, confining sweat within the channels. The ceramic ink‐printed boundary achieves higher pattern resolution, prevents fluid leakage, attains pattern thermal stability, and resistant to organic solvents. The cellulose matrix of the detection zones is modified with nanoparticles to improve the colour‐homogeneity and sweat sensor sensitivity. The swea...
Molecules
The use of proteins as biomolecular templates to synthesize atomically precise metal nanoclusters... more The use of proteins as biomolecular templates to synthesize atomically precise metal nanoclusters has been gaining traction due to their appealing properties such as photoluminescence, good colloidal- and photostability and biocompatibility. The synergistic effect of using a protein scaffold and metal nanoclusters makes it especially attractive for biomedical applications. Unlike other reviews, we focus on proteins in general as the protective ligand for various metal nanoclusters and highlight their applications in the biomedical field. We first introduce the approaches and underlined principles in synthesizing protein-templated metal nanoclusters and summarize some of the typical proteins that have been used thus far. Afterwards, we highlight the key physicochemical properties and the characterization techniques commonly used for the size, structure and optical properties of protein-templated metal nanoclusters. We feature two case studies to illustrate the importance of combining...
Continuous and in situ detection of biomarkers in biofluids (e.g., sweat) can provide critical he... more Continuous and in situ detection of biomarkers in biofluids (e.g., sweat) can provide critical health data but is limited by biofluids accessibility. Here, we report a sensor design that enables in situ detection of solid-state biomarkers ubiquitously present on human skin. We deploy an ionic-electronic bilayer hydrogel to facilitate the sequential dissolution, diffusion and electrochemical reaction of solid-state analytes. We demonstrate continuous monitoring of water-soluble analytes (i.e., solid lactate) and water-insoluble analytes (i.e., solid cholesterol) with ultralow detection limits of 0.51 nmol cm-2 and 0.26 nmol cm-2, respectively. Additionally, the bilayer hydrogel electrochemical interface reduces motion artifacts by three times compared to conventional liquid-sensing electrochemical interfaces. In a clinical study, solid-state epidermal biomarkers measured by our stretchable wearable sensors showed a high correlation with biomarkers in human blood and dynamically corre...