Host-derived plasminogen activator inhibitor-1 (PAI-1) concentration is critical for in vivo tumoral angiogenesis and growth (original) (raw)

Article (Scientific journals)

Host-derived plasminogen activator inhibitor-1 (PAI-1) concentration is critical for in vivo tumoral angiogenesis and growth

; Maillard, Catherine; Jost, M. et al.

2004 • In Oncogene, 23 (41), p. 6986-6990

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Keywords :

PAI-1; cancer invasion; tumoral angiogenesis; serine protease; protease inhibitor

Abstract :

[en] Plasminogen activator inhibitor type 1 (PAI-1) plays a key role in tumor progression and is believed to control proteolytic activity and cell migration during angiogenesis. We report here that host PAI-1, at physiological concentration, promotes in vivo tumor invasion and angiogenesis. In sharp contrast, inhibition of tumor vascularization was observed when PAI-1 was produced at supraphysiologic levels, either by host cells (transgenic mice overexpressing PAI-1) or by tumor cells (after transfection with murine PAI-1 cDNA). This study provides for the first time in vivo evidence for a dose-dependent effect of PAI-1 on tumor angiogenesis. Of great interest is the finding that PAI-1 produced by tumor cells, even at high concentration, did not overcome the absence of PAI-1 in the host, emphasizing the importance of the cellular source of PAI-1.

Disciplines :

Biochemistry, biophysics & molecular biology
Oncology

Author, co-author :

Bajou, Khalid ; Université de Liège - ULiège > Département des sciences de la vie > Biologie et génétique moléculaire

Maillard, Catherine ; Université de Liège - ULiège > Département des sciences cliniques > Labo de biologie des tumeurs et du développement

Jost, M.

Lijnen, R. H.

Gils, A.

Declerck, P.

Carmeliet, P.

Foidart, Jean-Michel ; Université de Liège - ULiège > Département des sciences cliniques > Gynécologie - Obstétrique

Noël, Agnès ; Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Biologie cellulaire et moléculaire appliquée à l'homme

Title :

Host-derived plasminogen activator inhibitor-1 (PAI-1) concentration is critical for in vivo tumoral angiogenesis and growth

Publication date :

09 September 2004

Publisher :

Nature, Basingstoke, United Kingdom

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 04 May 2009

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Scopus citations®
without self-citations

133

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