Ning An | Hefei University of technology (original) (raw)
Papers by Ning An
Oncotarget, Jan 23, 2016
Similarities in gene expression between both developing embryonic and precancerous tissues and ca... more Similarities in gene expression between both developing embryonic and precancerous tissues and cancer tissues may help identify much-needed biomarkers and therapeutic targets in lung squamous carcinoma. In this study, human lung samples representing ten successive time points, from embryonic development to carcinogenesis, were used to construct global gene expression profiles. Differentially expressed genes with similar expression in precancerous and cancer samples were identified. Using a network-based greedy searching algorithm to analyze the training cohort (n = 69) and three independent testing cohorts, we successfully identified a significant 22-gene module in which expression levels were correlated with overall survival in lung squamous carcinoma patients.
Biochemical and Biophysical Research Communications, Mar 30, 2007
The dentate gyrus (DG) of the hippocampus is one of a few regions in the adult mammalian brain ch... more The dentate gyrus (DG) of the hippocampus is one of a few regions in the adult mammalian brain characterized by ongoing neurogenesis. Proliferation of neural precursors in the granule cell layer of the DG has been identified in pentylenetetrazol (PTZ) kindling epilepsy model, however, little is known about the molecular mechanism. We previously reported that the expression pattern of bone morphogenetic proteins-4 (BMP4) mRNA in the hippocampus was developmentally regulated and mainly localized in the DG of the adult. To explore the role of BMP4 in epileptic activity, we detected BMP4 expression in the DG during PTZ kindling process and explore its correlation with cell proliferation combined with bromodeoxyuridine (BrdU) labeling technique. We found that dynamic changes in BMP4 level and BrdU labeled cells dependent on the kindling stage of PTZ induced seizure-prone state. The number of BMP4 mRNA-positive cells and BrdU labeled cells reached the top level 1 day after PTZ kindled, then declined to base level 2 months later. Furthermore, there was a significant correlation between increased BMP4 mRNA expression and increased number of BrdU labeled cells. After effectively blocked expression of BMP4 with antisense oligodeoxynucleotides(ASODN), the BrdU labeled cells in the dentate gyrus subgranular zone(DG-SGZ) and hilus were significantly decreased 16d after the first PTZ injection and 1, 3, 7, 14d after kindled respectively. These findings suggest that increased proliferation in the DG of the hippocampus resulted from kindling epilepsy elicited by PTZ maybe be modulated by BMP4 over-expression.
PloS one, 2015
Meeting the future food security challenge without further sacrificing environmental integrity re... more Meeting the future food security challenge without further sacrificing environmental integrity requires transformative changes in managing the key biophysical determinants of increasing agronomic productivity and reducing the environmental footprint. Here, we focus on Chinese rice production and quantitatively address this concern by conducting 403 on-farm trials across diverse rice farming systems. Inherent soil productivity, management practices and rice farming type resulted in confounded and interactive effects on yield, yield gaps and greenhouse gas (GHG) emissions (N2O, CH4 and CO2-equivalent) with both trade-offs and compensating effects. Advances in nitrogen, water and crop management (Best Management Practices-BMPs) helped closing existing yield gaps and resulted in a substantial reduction in CO2-equivalent emission of rice farming despite a tradeoff of increase N2O emission. However, inherent soil properties limited rice yields to a larger extent than previously known. Cul...
2013 ICME International Conference on Complex Medical Engineering, 2013
During their aging process, many seniors are likely to develop mild cognitive impairment which co... more During their aging process, many seniors are likely to develop mild cognitive impairment which could easily lead to Alzheimer's disease or dementia. Besides medication treatment, various reminiscence therapy methods have been proven to be effective in terms of enhancing the cognitive capacities of seniors, as well as improving their capabilities to participate in daily activities. This paper describes our design and implementation a reminiscence therapy game on Android tablet for Chinese seniors to help them maintain their memory capacities as well as their calculating abilities. To be more effective as a method of reminiscence therapy, we choose government food stamps that were mandated in China from 1960s to 1980s, as the backdrop of our game. With our experiment and further studies in the future, we aim to prove that this type of reminiscence therapy games can help seniors to maintain their memory capacity and postpone the development of potential Alzheimer's disease, and eventually dementia.
Proceedings of the 12th international conference on Information processing in sensor networks, 2013
Radio frequency based device-free passive (DfP) localization techniques have shown great potentia... more Radio frequency based device-free passive (DfP) localization techniques have shown great potentials in localizing individual human subjects, without requiring them to carry any radio devices. In this study, we extend the DfP technique to count and localize multiple subjects in indoor environments. To address the impact of multipath on indoor radio signals, we adopt a fingerprinting based approach to infer subject locations from observed signal strengths through profiling the environment. When multiple subjects are present, our objective is to use the profiling data collected by a single subject to count and localize multiple subjects without any extra effort. In order to address the non-linearity of the impact of multiple subjects, we propose a successive cancellation based algorithm to iteratively determine the number of subjects. We model indoor human trajectories as a state transition process, exploit indoor human mobility constraints and integrate all information into a conditional random field (CRF) to simultaneously localize multiple subjects. As a result, we call the proposed algorithm SCPLsequential counting, parallel localizing. We test SCPL with two different indoor settings, one with size 150 m 2 and the other 400 m 2. In each setting, we have four different subjects, walking around in the deployed areas, sometimes with overlapping trajectories. Through extensive experimental results, we show that SCPL can count the present subjects with 86% counting percentage when their trajectories are not completely overlapping. Our localization algorithms are also highly accurate, with an average localization error distance of 1.3 m.
Chinese Journal of Chemistry, 2015
Carbon based nanomaterials (carbon nanotubes, graphene etc) containing various hetero atoms are p... more Carbon based nanomaterials (carbon nanotubes, graphene etc) containing various hetero atoms are promising metal free catalysts for oxygen reduction reaction in fuel cells. We report the non-covalent functionalization of graphene with poly(diallyl dimethylammonium) chloride (PDDA), a polyelectrolyte containing nitrogen, using a very simple method. The addition of a non-ionic surfactant (Triton X-100) during functionalization has been observed to improve the interactions between graphene and PDDA. An up-shift in the position of G-peak in the Raman spectra, down-shift in the binding energy (B.E.) of N1s peak and an up-shift in the B.E. of C1s peak in XPS spectra have been observed due to an intermolecular charge-transfer from carbon in graphene to nitrogen in PDDA, which get enhanced in the presence of Triton X-100. Graphene functionalized with PDDA also show good thermal stability. The addition of a non-ionic surfactant enhances the non-covalent functionalization of graphene with PDDA, which is desirable from applications point of view.
2011 Eighth International Conference Computer Graphics, Imaging and Visualization, 2011
An image segmentation approach by improved watershed partition and DCT energy compaction has been... more An image segmentation approach by improved watershed partition and DCT energy compaction has been proposed in this paper. The proposed energy compaction, which expresses the local texture of an image area, is derived by exploiting the discrete cosine transform. The algorithm is a hybrid segmentation technique which is composed of three stages. First, the watershed transform is utilized by preprocessing techniques: edge detection and marker in order to partition the image in to several small disjoint patches, while the region size, mean and variance features are used to calculate region cost for combination. Then in the second merging stage the DCT transform is used for energy compaction which is a criterion for texture comparison and region merging. Finally the image can be segmented into several partitions. The experimental results show that the proposed approach achieved very good segmentation robustness and efficiency, when compared to other state of the art image segmentation algorithms and human segmentation results.
Journal of Applied Polymer Science, 2014
ABSTRACTWe report preparation of graphene oxide (GO) from expanded graphite (EG) via a modified H... more ABSTRACTWe report preparation of graphene oxide (GO) from expanded graphite (EG) via a modified Hummers method. GO/PVDF composites films were obtained using solvent N, N‐Dimethylformamide (DMF) and cosolvent comprising deionized water/DMF combination. X‐ray diffraction (XRD) and Fourier transform infrared spectroscopy (FTIR) analyses revealed that the main crystal structure of the composite films is β‐phase, and use cosolvent method tends to favor the formation of β‐phase. Scanning electron microscopy (SEM) was used to investigate the microstructure of composite films. Storage modulus and loss modulus were measured by Dynamic mechanical analysis (DMA). Broadband dielectric spectrum tests showed an increase in the dielectric constant of the GO/PVDF composite films with the rising content of GO, and by cosolvent method could improve the dielectric constant while reducing the dielectric loss. Our method that uses GO as an additive and deionized water/DMF as the cosolvent provides a pro...
2013 10th International Conference Computer Graphics, Imaging and Visualization, 2013
Graph cuts based interactive segmentation has drawn a lot of attention in recent years. In origin... more Graph cuts based interactive segmentation has drawn a lot of attention in recent years. In original graph cuts, the extraction of foreground object from its background often leads to many mistakes and the histogram distribution for energy function is not enough. In this paper, an iterated graph cut algorithm integrating texture characterization is proposed. We utilize user intervention to cycle the object approximately in the beginning, and the image is divided into superpixels by "SLIC" method. After initialization Gaussian mixture model (GMM) by RGB colors, we use a vector which combines color model and texture description for the estimation of GMM parameters. Then min-cut algorithm is applied in the graph for energy minimization, so GMM adjust their clusters and recompute the parameters. The process iterates until min-cut algorithm converges. Finally, we give a comparison between our method and "GrabCut". The experiments show that our have good results.
Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae, 2002
To evaluate the necessity, scientificity, and feasibility of the drafted Practice Guidelines on P... more To evaluate the necessity, scientificity, and feasibility of the drafted Practice Guidelines on Prevention and Treatment of Hypertension for Primary Care Physicians. Derivative Dolphe Method was used to collect the responses from 50 experts in hypertension or related fields within the nation. An evaluation score of 1 to 5 was given to each item for selection, 1 for highly disagreed and 5 for highly agreed. The mean, standard deviation (SD) and coefficient of variance (CV) of the scores were calculated. (1) 90% experts responded to the evaluation sheet. (2) The mean score were above 4 for the five out of the six items related to necessity, the SD varied from 0.51 to 1.05, and the CV from 0.11 to 0.30. (3) Among the 28 items related to scientificity and rationality, the mean score was above 4 for 25 items and was between 3.5 and 4 for other three items. The CV was generally lower than 0.35. (4) Among the seven items related to feasibility, the mean score for five of them was lower tha...
Yao xue xue bao = Acta pharmaceutica Sinica, 2006
To investigate the glycosidic constituents in the rhizomes of Alpinia officinarum Hance. The isol... more To investigate the glycosidic constituents in the rhizomes of Alpinia officinarum Hance. The isolation and purification of glycosides were done with column chromatography on macro porous resin, polyamides and Sephadex LH-20, whilst the structure elucidation was done by HRCI-MS and NMR (1D and 2D) methods. A glycosidic ester identified as 4'-hydroxy-2'-methoxyphenol-beta-D-{6-0-[4"-hydroxy-3", 5"-dimethoxy (benzoate)]}-glucopyranoside (I), along with a known compound n-butyl-beta-D-fructopyranoside (II), were isolated and characterized. I was found to be a new compound, named as alpinoside A, whilst II was isolated from the genus Alpinia for the first time.
AMIA Joint Summits on Translational Science proceedings AMIA Summit on Translational Science, 2013
Here we describe a prediction-based framework to analyze omic data and generate models for both d... more Here we describe a prediction-based framework to analyze omic data and generate models for both disease diagnosis and identification of cellular pathways which are significant in complex diseases. Our framework differs from previous analysis in its use of underlying biology (cellular pathways/gene-sets) to produce predictive feature-disease models. In our study of alcoholism, lung cancer, and schizophrenia, we demonstrate the framework's ability to robustly analyze omic data of multiple types and sources, identify significant features sets, and produce accurate predictive models.
PLoS ONE, 2014
Background: The quality of reporting in systematic reviews (SRs)/meta-analyses (MAs) of diagnosti... more Background: The quality of reporting in systematic reviews (SRs)/meta-analyses (MAs) of diagnostic tests published by authors in China has not been evaluated. The aims of present study are to evaluate the quality of reporting in diagnostic SRs/MAs using the PRISMA statement and determine the changes in the quality of reporting over time. Methods: According to the inclusion and exclusion criteria, we searched five databases including Chinese Biomedical Literature Database, PubMed, EMBASE, the Cochrane Library, and Web of knowledge, to identify SRs/MAs on diagnostic tests. The searches were conducted on July 14, 2012 and the cut off for inclusion of the SRs/MAs was December 31 st 2011. The PRISMA statement was used to assess the quality of reporting. Analysis was performed using Excel 2003, RevMan 5. Results: A total of 312 studies were included. Fifteen diseases systems were covered. According to the PRISMA checklist, there had been serious reporting flaws in following items: structured summary (item 2, 22.4%), objectives (item 4, 18.9%), protocol and registration (item 5, 2.6%), risk of bias across studies (item 15, 26.3%), funding (item 27, 28.8%). The subgroup analysis showed that there had been some statistically significant improvement in total compliance for 9 PRISMA items after the PRISMA was released, 6 items were statistically improved regarding funded articles, 3 items were statistically improved for CSCD articles, and there was a statistically significant increase in the proportion of reviews reporting on 22 items for SCI articles (P,0.050). Conclusion: The numbers of diagnostic SRs/MAs is increasing annually. The quality of reporting has measurably been improved over the previous years. Unfortunately, there are still many deficiencies in the reporting including protocol and registration, search, risk of bias across studies, and funding. Future Chinese reviewers should address issues on these aspects.
Journal of Alloys and Compounds, 2012
A series of metal oxide solid solutions Bi 1−x Dy x VO 4 and Bi 0.5 M 0.5 VO 4 (M = La, Sm, Nd, G... more A series of metal oxide solid solutions Bi 1−x Dy x VO 4 and Bi 0.5 M 0.5 VO 4 (M = La, Sm, Nd, Gd, Eu, Y) were synthesized by solid state reaction at high temperature and characterized by XRD, UV-vis DRS, BET, SEM. Bi 1−x Dy x VO 4 showed two crystal structures with the component content. For 0.3 ≤ x ≤1.0, the structure was tetragonal type, while that was monoclinic when x = 0. For 0.1 ≤ x < 0.3, tetragonal and monoclinic structures had been observed. Bi 1−x Dy x VO 4 solid solutions of tetragonal type could split water into H 2 and O 2 simultaneously when loaded with 0.3 wt% Pt and 1 wt% Pt-Cr 2 O 3 respectively as cocatalyst. Among these catalysts, Bi 0.5 Dy 0.5 VO 4 showed the best photocatalytic activity for water splitting under UV light irradiation. Besides, Bi 0.5 M 0.5 VO 4 (M = La, Sm, Nd, Gd, Eu, Y) were also prepared and discovered to be of tetragonal type as same as Bi 0.5 Dy 0.5 VO 4. They performed high photocatalytic activities of splitting pure water into H 2 and O 2 under UV light irradiation when loaded with 1 wt% Pt-Cr 2 O 3. The activities of Bi 0.5 M 0.5 VO 4 (M = Dy, La, Sm, Nd, Gd, Eu, Y) solid solutions indicated band-gap engineering of metal oxide solid solutions was the feasible method to obtain a photocatalyst for overall water splitting.
International Journal of Hydrogen Energy, 2014
TiO 2 photocatalysts loaded CuS and NiS as co-catalyst were prepared by hydrothermal approach and... more TiO 2 photocatalysts loaded CuS and NiS as co-catalyst were prepared by hydrothermal approach and characterized by XRD, UVevisible DRS, BET, XPS, SEM and TEM. When TiO 2 was loaded MS as co-catalyst, it showed higher photocatalytic activities for splitting water into hydrogen in methanol aqueous solution under 500 W Xe lamp. Among the photocatalysts with various compositions, the maximum evolution of H 2 obtained from 5 wt% CuSe5 wt% NiSeTiO 2 sample was about 800 mmol h À1 , which was increased up to about twenty-eight times than that of TiO 2 alone. It was proven that CuS, NiS can act as effective dual co-catalysts to enhance the photocatalytic H 2 production activity of TiO 2 .
Food Chemistry, 2010
ABSTRACT Three diarylheptanoids, officinaruminane A (1), officinaruminane B (2), 5(S)-acetoxy-7-(... more ABSTRACT Three diarylheptanoids, officinaruminane A (1), officinaruminane B (2), 5(S)-acetoxy-7-(4-dihydroxyphenyl)-1-phenyl-3-heptanone (3), together with six known ones , (5R)-5-hydroxy-1-(4-hydroxyphenyl)-7-(4-hydroxy-3-methoxyphenyl)-3-heptanone (4),(5R)-5-hydroxy-1-(4-hydroxy-3-methoxyphenyl)-7-(4,5-dihydroxy-3-methoxyphenyl)-3-heptanone (5), 1-phenyl-7-(4-hydroxy-3-methoxyphenyl)-4E-en-3-heptanone (6), 1-(4-hydroxyphenyl)-7-(4-hydroxy-3-methoxyphenyl)-4E-en-3-heptanone (7), 1-phenyl-7-(4-hydroxyphenyl)- 4E- en-3-heptanone (8), and 3,6-furan-7-(4′′-hydroxy-3′′-methoxyphenyl)-1-phenylheptane (9), were isolated from the rhizomes of Alpinia officinarum Hance by column chromatography on silica gel, MPLC and preparative thin-layer chromatography (TLC). The structures of these compounds were elucidated on the basis of mass spectrometry, 1H NMR, 13C NMR, HMQC and HMBC data. Among them, 1 is a diarylheptanoid with a pyridine ring, and 2 is a diarylheptane monoterpene.
Clinical Therapeutics, 2004
Background: A low-dose combination of perindopril and indapamide may effectively reduce blood pre... more Background: A low-dose combination of perindopril and indapamide may effectively reduce blood pressure (BP) in hypertensive patients, but some factors related to study design might have contributed to the betweengroup differences in the rate of reduction of BP observed in some trials. Objective: The aim of this study was to systematically assess the efficacy and safety profiles (through review of randomized, controlled trials) of the fixed, low-dose combination perindopril 2 mg and indapamide 0.625 mg given as 1 tablet daily as first-line antihypertensive therapy in patients with mild to moderate hypertension.
The Web Conference, Apr 20, 2009
Classic database indexes (e.g., B +-Tree), though speed up queries, suffer from two main drawback... more Classic database indexes (e.g., B +-Tree), though speed up queries, suffer from two main drawbacks: (1) An index usually yields 5% to 15% additional storage overhead which results in non-ignorable dollar cost in big data scenarios especially when deployed on modern storage devices. (2) Maintaining an index incurs high latency because the DBMS has to locate and update those index pages affected by the underlying table changes. This paper proposes Hippo a fast, yet scalable, database indexing approach. It significantly shrinks the index storage and mitigates maintenance overhead without compromising much on the query execution performance. Hippo stores disk page ranges instead of tuple pointers in the indexed table to reduce the storage space occupied by the index. It maintains simplified histograms that represent the data distribution and adopts a page grouping technique that groups contiguous pages into page ranges based on the similarity of their index key attribute distributions. When a query is issued, Hippo leverages the page ranges and histogram-based page summaries to recognize those pages such that their tuples are guaranteed not to satisfy the query predicates and inspects the remaining pages. Experiments based on real and synthetic datasets show that Hippo occupies up to two orders of magnitude less storage space than that of the B +-Tree while still achieving comparable query execution performance to that of the B +-Tree for 0.1%-1% selectivity factors. Also, the experiments show that Hippo outperforms BRIN (Block Range Index) in executing queries with various selectivity factors. Furthermore, Hippo achieves up to three orders of magnitude less maintenance overhead and up to an order of magnitude higher throughput (for hybrid query/update workloads) than its counterparts.
Oncotarget, Jan 23, 2016
Similarities in gene expression between both developing embryonic and precancerous tissues and ca... more Similarities in gene expression between both developing embryonic and precancerous tissues and cancer tissues may help identify much-needed biomarkers and therapeutic targets in lung squamous carcinoma. In this study, human lung samples representing ten successive time points, from embryonic development to carcinogenesis, were used to construct global gene expression profiles. Differentially expressed genes with similar expression in precancerous and cancer samples were identified. Using a network-based greedy searching algorithm to analyze the training cohort (n = 69) and three independent testing cohorts, we successfully identified a significant 22-gene module in which expression levels were correlated with overall survival in lung squamous carcinoma patients.
Biochemical and Biophysical Research Communications, Mar 30, 2007
The dentate gyrus (DG) of the hippocampus is one of a few regions in the adult mammalian brain ch... more The dentate gyrus (DG) of the hippocampus is one of a few regions in the adult mammalian brain characterized by ongoing neurogenesis. Proliferation of neural precursors in the granule cell layer of the DG has been identified in pentylenetetrazol (PTZ) kindling epilepsy model, however, little is known about the molecular mechanism. We previously reported that the expression pattern of bone morphogenetic proteins-4 (BMP4) mRNA in the hippocampus was developmentally regulated and mainly localized in the DG of the adult. To explore the role of BMP4 in epileptic activity, we detected BMP4 expression in the DG during PTZ kindling process and explore its correlation with cell proliferation combined with bromodeoxyuridine (BrdU) labeling technique. We found that dynamic changes in BMP4 level and BrdU labeled cells dependent on the kindling stage of PTZ induced seizure-prone state. The number of BMP4 mRNA-positive cells and BrdU labeled cells reached the top level 1 day after PTZ kindled, then declined to base level 2 months later. Furthermore, there was a significant correlation between increased BMP4 mRNA expression and increased number of BrdU labeled cells. After effectively blocked expression of BMP4 with antisense oligodeoxynucleotides(ASODN), the BrdU labeled cells in the dentate gyrus subgranular zone(DG-SGZ) and hilus were significantly decreased 16d after the first PTZ injection and 1, 3, 7, 14d after kindled respectively. These findings suggest that increased proliferation in the DG of the hippocampus resulted from kindling epilepsy elicited by PTZ maybe be modulated by BMP4 over-expression.
PloS one, 2015
Meeting the future food security challenge without further sacrificing environmental integrity re... more Meeting the future food security challenge without further sacrificing environmental integrity requires transformative changes in managing the key biophysical determinants of increasing agronomic productivity and reducing the environmental footprint. Here, we focus on Chinese rice production and quantitatively address this concern by conducting 403 on-farm trials across diverse rice farming systems. Inherent soil productivity, management practices and rice farming type resulted in confounded and interactive effects on yield, yield gaps and greenhouse gas (GHG) emissions (N2O, CH4 and CO2-equivalent) with both trade-offs and compensating effects. Advances in nitrogen, water and crop management (Best Management Practices-BMPs) helped closing existing yield gaps and resulted in a substantial reduction in CO2-equivalent emission of rice farming despite a tradeoff of increase N2O emission. However, inherent soil properties limited rice yields to a larger extent than previously known. Cul...
2013 ICME International Conference on Complex Medical Engineering, 2013
During their aging process, many seniors are likely to develop mild cognitive impairment which co... more During their aging process, many seniors are likely to develop mild cognitive impairment which could easily lead to Alzheimer's disease or dementia. Besides medication treatment, various reminiscence therapy methods have been proven to be effective in terms of enhancing the cognitive capacities of seniors, as well as improving their capabilities to participate in daily activities. This paper describes our design and implementation a reminiscence therapy game on Android tablet for Chinese seniors to help them maintain their memory capacities as well as their calculating abilities. To be more effective as a method of reminiscence therapy, we choose government food stamps that were mandated in China from 1960s to 1980s, as the backdrop of our game. With our experiment and further studies in the future, we aim to prove that this type of reminiscence therapy games can help seniors to maintain their memory capacity and postpone the development of potential Alzheimer's disease, and eventually dementia.
Proceedings of the 12th international conference on Information processing in sensor networks, 2013
Radio frequency based device-free passive (DfP) localization techniques have shown great potentia... more Radio frequency based device-free passive (DfP) localization techniques have shown great potentials in localizing individual human subjects, without requiring them to carry any radio devices. In this study, we extend the DfP technique to count and localize multiple subjects in indoor environments. To address the impact of multipath on indoor radio signals, we adopt a fingerprinting based approach to infer subject locations from observed signal strengths through profiling the environment. When multiple subjects are present, our objective is to use the profiling data collected by a single subject to count and localize multiple subjects without any extra effort. In order to address the non-linearity of the impact of multiple subjects, we propose a successive cancellation based algorithm to iteratively determine the number of subjects. We model indoor human trajectories as a state transition process, exploit indoor human mobility constraints and integrate all information into a conditional random field (CRF) to simultaneously localize multiple subjects. As a result, we call the proposed algorithm SCPLsequential counting, parallel localizing. We test SCPL with two different indoor settings, one with size 150 m 2 and the other 400 m 2. In each setting, we have four different subjects, walking around in the deployed areas, sometimes with overlapping trajectories. Through extensive experimental results, we show that SCPL can count the present subjects with 86% counting percentage when their trajectories are not completely overlapping. Our localization algorithms are also highly accurate, with an average localization error distance of 1.3 m.
Chinese Journal of Chemistry, 2015
Carbon based nanomaterials (carbon nanotubes, graphene etc) containing various hetero atoms are p... more Carbon based nanomaterials (carbon nanotubes, graphene etc) containing various hetero atoms are promising metal free catalysts for oxygen reduction reaction in fuel cells. We report the non-covalent functionalization of graphene with poly(diallyl dimethylammonium) chloride (PDDA), a polyelectrolyte containing nitrogen, using a very simple method. The addition of a non-ionic surfactant (Triton X-100) during functionalization has been observed to improve the interactions between graphene and PDDA. An up-shift in the position of G-peak in the Raman spectra, down-shift in the binding energy (B.E.) of N1s peak and an up-shift in the B.E. of C1s peak in XPS spectra have been observed due to an intermolecular charge-transfer from carbon in graphene to nitrogen in PDDA, which get enhanced in the presence of Triton X-100. Graphene functionalized with PDDA also show good thermal stability. The addition of a non-ionic surfactant enhances the non-covalent functionalization of graphene with PDDA, which is desirable from applications point of view.
2011 Eighth International Conference Computer Graphics, Imaging and Visualization, 2011
An image segmentation approach by improved watershed partition and DCT energy compaction has been... more An image segmentation approach by improved watershed partition and DCT energy compaction has been proposed in this paper. The proposed energy compaction, which expresses the local texture of an image area, is derived by exploiting the discrete cosine transform. The algorithm is a hybrid segmentation technique which is composed of three stages. First, the watershed transform is utilized by preprocessing techniques: edge detection and marker in order to partition the image in to several small disjoint patches, while the region size, mean and variance features are used to calculate region cost for combination. Then in the second merging stage the DCT transform is used for energy compaction which is a criterion for texture comparison and region merging. Finally the image can be segmented into several partitions. The experimental results show that the proposed approach achieved very good segmentation robustness and efficiency, when compared to other state of the art image segmentation algorithms and human segmentation results.
Journal of Applied Polymer Science, 2014
ABSTRACTWe report preparation of graphene oxide (GO) from expanded graphite (EG) via a modified H... more ABSTRACTWe report preparation of graphene oxide (GO) from expanded graphite (EG) via a modified Hummers method. GO/PVDF composites films were obtained using solvent N, N‐Dimethylformamide (DMF) and cosolvent comprising deionized water/DMF combination. X‐ray diffraction (XRD) and Fourier transform infrared spectroscopy (FTIR) analyses revealed that the main crystal structure of the composite films is β‐phase, and use cosolvent method tends to favor the formation of β‐phase. Scanning electron microscopy (SEM) was used to investigate the microstructure of composite films. Storage modulus and loss modulus were measured by Dynamic mechanical analysis (DMA). Broadband dielectric spectrum tests showed an increase in the dielectric constant of the GO/PVDF composite films with the rising content of GO, and by cosolvent method could improve the dielectric constant while reducing the dielectric loss. Our method that uses GO as an additive and deionized water/DMF as the cosolvent provides a pro...
2013 10th International Conference Computer Graphics, Imaging and Visualization, 2013
Graph cuts based interactive segmentation has drawn a lot of attention in recent years. In origin... more Graph cuts based interactive segmentation has drawn a lot of attention in recent years. In original graph cuts, the extraction of foreground object from its background often leads to many mistakes and the histogram distribution for energy function is not enough. In this paper, an iterated graph cut algorithm integrating texture characterization is proposed. We utilize user intervention to cycle the object approximately in the beginning, and the image is divided into superpixels by "SLIC" method. After initialization Gaussian mixture model (GMM) by RGB colors, we use a vector which combines color model and texture description for the estimation of GMM parameters. Then min-cut algorithm is applied in the graph for energy minimization, so GMM adjust their clusters and recompute the parameters. The process iterates until min-cut algorithm converges. Finally, we give a comparison between our method and "GrabCut". The experiments show that our have good results.
Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae, 2002
To evaluate the necessity, scientificity, and feasibility of the drafted Practice Guidelines on P... more To evaluate the necessity, scientificity, and feasibility of the drafted Practice Guidelines on Prevention and Treatment of Hypertension for Primary Care Physicians. Derivative Dolphe Method was used to collect the responses from 50 experts in hypertension or related fields within the nation. An evaluation score of 1 to 5 was given to each item for selection, 1 for highly disagreed and 5 for highly agreed. The mean, standard deviation (SD) and coefficient of variance (CV) of the scores were calculated. (1) 90% experts responded to the evaluation sheet. (2) The mean score were above 4 for the five out of the six items related to necessity, the SD varied from 0.51 to 1.05, and the CV from 0.11 to 0.30. (3) Among the 28 items related to scientificity and rationality, the mean score was above 4 for 25 items and was between 3.5 and 4 for other three items. The CV was generally lower than 0.35. (4) Among the seven items related to feasibility, the mean score for five of them was lower tha...
Yao xue xue bao = Acta pharmaceutica Sinica, 2006
To investigate the glycosidic constituents in the rhizomes of Alpinia officinarum Hance. The isol... more To investigate the glycosidic constituents in the rhizomes of Alpinia officinarum Hance. The isolation and purification of glycosides were done with column chromatography on macro porous resin, polyamides and Sephadex LH-20, whilst the structure elucidation was done by HRCI-MS and NMR (1D and 2D) methods. A glycosidic ester identified as 4'-hydroxy-2'-methoxyphenol-beta-D-{6-0-[4"-hydroxy-3", 5"-dimethoxy (benzoate)]}-glucopyranoside (I), along with a known compound n-butyl-beta-D-fructopyranoside (II), were isolated and characterized. I was found to be a new compound, named as alpinoside A, whilst II was isolated from the genus Alpinia for the first time.
AMIA Joint Summits on Translational Science proceedings AMIA Summit on Translational Science, 2013
Here we describe a prediction-based framework to analyze omic data and generate models for both d... more Here we describe a prediction-based framework to analyze omic data and generate models for both disease diagnosis and identification of cellular pathways which are significant in complex diseases. Our framework differs from previous analysis in its use of underlying biology (cellular pathways/gene-sets) to produce predictive feature-disease models. In our study of alcoholism, lung cancer, and schizophrenia, we demonstrate the framework's ability to robustly analyze omic data of multiple types and sources, identify significant features sets, and produce accurate predictive models.
PLoS ONE, 2014
Background: The quality of reporting in systematic reviews (SRs)/meta-analyses (MAs) of diagnosti... more Background: The quality of reporting in systematic reviews (SRs)/meta-analyses (MAs) of diagnostic tests published by authors in China has not been evaluated. The aims of present study are to evaluate the quality of reporting in diagnostic SRs/MAs using the PRISMA statement and determine the changes in the quality of reporting over time. Methods: According to the inclusion and exclusion criteria, we searched five databases including Chinese Biomedical Literature Database, PubMed, EMBASE, the Cochrane Library, and Web of knowledge, to identify SRs/MAs on diagnostic tests. The searches were conducted on July 14, 2012 and the cut off for inclusion of the SRs/MAs was December 31 st 2011. The PRISMA statement was used to assess the quality of reporting. Analysis was performed using Excel 2003, RevMan 5. Results: A total of 312 studies were included. Fifteen diseases systems were covered. According to the PRISMA checklist, there had been serious reporting flaws in following items: structured summary (item 2, 22.4%), objectives (item 4, 18.9%), protocol and registration (item 5, 2.6%), risk of bias across studies (item 15, 26.3%), funding (item 27, 28.8%). The subgroup analysis showed that there had been some statistically significant improvement in total compliance for 9 PRISMA items after the PRISMA was released, 6 items were statistically improved regarding funded articles, 3 items were statistically improved for CSCD articles, and there was a statistically significant increase in the proportion of reviews reporting on 22 items for SCI articles (P,0.050). Conclusion: The numbers of diagnostic SRs/MAs is increasing annually. The quality of reporting has measurably been improved over the previous years. Unfortunately, there are still many deficiencies in the reporting including protocol and registration, search, risk of bias across studies, and funding. Future Chinese reviewers should address issues on these aspects.
Journal of Alloys and Compounds, 2012
A series of metal oxide solid solutions Bi 1−x Dy x VO 4 and Bi 0.5 M 0.5 VO 4 (M = La, Sm, Nd, G... more A series of metal oxide solid solutions Bi 1−x Dy x VO 4 and Bi 0.5 M 0.5 VO 4 (M = La, Sm, Nd, Gd, Eu, Y) were synthesized by solid state reaction at high temperature and characterized by XRD, UV-vis DRS, BET, SEM. Bi 1−x Dy x VO 4 showed two crystal structures with the component content. For 0.3 ≤ x ≤1.0, the structure was tetragonal type, while that was monoclinic when x = 0. For 0.1 ≤ x < 0.3, tetragonal and monoclinic structures had been observed. Bi 1−x Dy x VO 4 solid solutions of tetragonal type could split water into H 2 and O 2 simultaneously when loaded with 0.3 wt% Pt and 1 wt% Pt-Cr 2 O 3 respectively as cocatalyst. Among these catalysts, Bi 0.5 Dy 0.5 VO 4 showed the best photocatalytic activity for water splitting under UV light irradiation. Besides, Bi 0.5 M 0.5 VO 4 (M = La, Sm, Nd, Gd, Eu, Y) were also prepared and discovered to be of tetragonal type as same as Bi 0.5 Dy 0.5 VO 4. They performed high photocatalytic activities of splitting pure water into H 2 and O 2 under UV light irradiation when loaded with 1 wt% Pt-Cr 2 O 3. The activities of Bi 0.5 M 0.5 VO 4 (M = Dy, La, Sm, Nd, Gd, Eu, Y) solid solutions indicated band-gap engineering of metal oxide solid solutions was the feasible method to obtain a photocatalyst for overall water splitting.
International Journal of Hydrogen Energy, 2014
TiO 2 photocatalysts loaded CuS and NiS as co-catalyst were prepared by hydrothermal approach and... more TiO 2 photocatalysts loaded CuS and NiS as co-catalyst were prepared by hydrothermal approach and characterized by XRD, UVevisible DRS, BET, XPS, SEM and TEM. When TiO 2 was loaded MS as co-catalyst, it showed higher photocatalytic activities for splitting water into hydrogen in methanol aqueous solution under 500 W Xe lamp. Among the photocatalysts with various compositions, the maximum evolution of H 2 obtained from 5 wt% CuSe5 wt% NiSeTiO 2 sample was about 800 mmol h À1 , which was increased up to about twenty-eight times than that of TiO 2 alone. It was proven that CuS, NiS can act as effective dual co-catalysts to enhance the photocatalytic H 2 production activity of TiO 2 .
Food Chemistry, 2010
ABSTRACT Three diarylheptanoids, officinaruminane A (1), officinaruminane B (2), 5(S)-acetoxy-7-(... more ABSTRACT Three diarylheptanoids, officinaruminane A (1), officinaruminane B (2), 5(S)-acetoxy-7-(4-dihydroxyphenyl)-1-phenyl-3-heptanone (3), together with six known ones , (5R)-5-hydroxy-1-(4-hydroxyphenyl)-7-(4-hydroxy-3-methoxyphenyl)-3-heptanone (4),(5R)-5-hydroxy-1-(4-hydroxy-3-methoxyphenyl)-7-(4,5-dihydroxy-3-methoxyphenyl)-3-heptanone (5), 1-phenyl-7-(4-hydroxy-3-methoxyphenyl)-4E-en-3-heptanone (6), 1-(4-hydroxyphenyl)-7-(4-hydroxy-3-methoxyphenyl)-4E-en-3-heptanone (7), 1-phenyl-7-(4-hydroxyphenyl)- 4E- en-3-heptanone (8), and 3,6-furan-7-(4′′-hydroxy-3′′-methoxyphenyl)-1-phenylheptane (9), were isolated from the rhizomes of Alpinia officinarum Hance by column chromatography on silica gel, MPLC and preparative thin-layer chromatography (TLC). The structures of these compounds were elucidated on the basis of mass spectrometry, 1H NMR, 13C NMR, HMQC and HMBC data. Among them, 1 is a diarylheptanoid with a pyridine ring, and 2 is a diarylheptane monoterpene.
Clinical Therapeutics, 2004
Background: A low-dose combination of perindopril and indapamide may effectively reduce blood pre... more Background: A low-dose combination of perindopril and indapamide may effectively reduce blood pressure (BP) in hypertensive patients, but some factors related to study design might have contributed to the betweengroup differences in the rate of reduction of BP observed in some trials. Objective: The aim of this study was to systematically assess the efficacy and safety profiles (through review of randomized, controlled trials) of the fixed, low-dose combination perindopril 2 mg and indapamide 0.625 mg given as 1 tablet daily as first-line antihypertensive therapy in patients with mild to moderate hypertension.
The Web Conference, Apr 20, 2009
Classic database indexes (e.g., B +-Tree), though speed up queries, suffer from two main drawback... more Classic database indexes (e.g., B +-Tree), though speed up queries, suffer from two main drawbacks: (1) An index usually yields 5% to 15% additional storage overhead which results in non-ignorable dollar cost in big data scenarios especially when deployed on modern storage devices. (2) Maintaining an index incurs high latency because the DBMS has to locate and update those index pages affected by the underlying table changes. This paper proposes Hippo a fast, yet scalable, database indexing approach. It significantly shrinks the index storage and mitigates maintenance overhead without compromising much on the query execution performance. Hippo stores disk page ranges instead of tuple pointers in the indexed table to reduce the storage space occupied by the index. It maintains simplified histograms that represent the data distribution and adopts a page grouping technique that groups contiguous pages into page ranges based on the similarity of their index key attribute distributions. When a query is issued, Hippo leverages the page ranges and histogram-based page summaries to recognize those pages such that their tuples are guaranteed not to satisfy the query predicates and inspects the remaining pages. Experiments based on real and synthetic datasets show that Hippo occupies up to two orders of magnitude less storage space than that of the B +-Tree while still achieving comparable query execution performance to that of the B +-Tree for 0.1%-1% selectivity factors. Also, the experiments show that Hippo outperforms BRIN (Block Range Index) in executing queries with various selectivity factors. Furthermore, Hippo achieves up to three orders of magnitude less maintenance overhead and up to an order of magnitude higher throughput (for hybrid query/update workloads) than its counterparts.