Rishikesh Kalaria | Hinduja Hospital (original) (raw)

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Papers by Rishikesh Kalaria

Research paper thumbnail of Temporal change in phenotypic behaviour in patients with Crohn’s disease: Do Indian patients behave differently from Western and other Asian patients?

Journal of Crohn's and Colitis, 2015

Research paper thumbnail of Rate of recurrence in Indian patients presenting with acute pancreatitis and identification of chronicity on follow up: Possible risk factors for progression

Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology, Mar 7, 2018

To study the profile and long-term outcome of Indian patients presenting with acute pancreatitis ... more To study the profile and long-term outcome of Indian patients presenting with acute pancreatitis and the possible risk factors for progression. Consecutive patients with acute or recurrent acute pancreatitis seen in our department during July 2013 to December 2014 were included. Details of past episodes were collected and patients were followed up till March 2015. In the 97 patients included (mean age 47.2 [SD 16.9] years; 74 men), gallstones (37 [38.1%]) and alcohol (19 [19.6%]) were the major identified etiologies; the idiopathic (31 [32%]) group constituted a third of patients. Recurrences were more common with idiopathic etiology (14 patients out of 30 had recurrences [46.7%]) as compared to alcoholic (5 out of 19 [26.3%]) and biliary (4 out of 37 [10.8%]) pancreatitis and with mild index episode. Following the episode of acute pancreatitis, identification of chronic pancreatitis was more common with alcoholic (6 out of 18 [33%]) and idiopathic (9 out of 30 [30%]) etiology as co...

Research paper thumbnail of Temporal change in phenotypic behaviour in patients with Crohn’s disease: Do Indian patients behave differently from Western and other Asian patients?

Journal of Crohn's and Colitis, 2015

In Western studies, one-third of patients with Crohn&... more In Western studies, one-third of patients with Crohn's disease have stricturing or penetrating disease at presentation and one-half will progress to complicated disease in 20 years. Asian studies indicate that the disease phenotype may be different. Our aim was to study the disease behaviour in Indian patients with Crohn's disease. In this hospital based study, we analysed (Montreal classification) disease phenotype, presence of perianal disease, need for intestinal surgery, and changes in the Montreal classification over time in Crohn's disease patients from our database. In the 178 patients (median age 35, IQR 21 years; 97 males) with Crohn's disease, the proportion of various features: more patients had ileo-colonic(L3: 43.8%) than ileal(L1: 27.5%) or colonic(L2: 28.7%) disease; perianal disease was seen in 11.8% at baseline. Non-stricturing non-fistulising disease(B1) was seen in 74.7%, 65.7%, 50% and 44.4% at baseline, at 5, 10 and 15 years, respectively; stricturing disease(B2) in 21.4%, 21.9%, 28.9% and 33.3%; and penetrating disease(B3) in 3.9%, 11.4%, 21% and 16.7%, intestinal surgery required in 10.7%, 20%, 34.2% and 55.5% respectively. Kaplan-Meier analysis showed no association between progression of disease and patient age and location of the disease. Gender distribution and predominant ileo-colonic location of disease were similar to earlier Asian reports on Crohn's disease. Perianal disease was less frequent than reported in Western and other Asian studies. One-fourth of Indian patients had aggressive disease at diagnosis, but the tendency to progress towards aggressive disease over time was less pronounced than in Western patients.

Research paper thumbnail of Temporal change in phenotypic behaviour in patients with Crohn’s disease: Do Indian patients behave differently from Western and other Asian patients?

Journal of Crohn's and Colitis, 2015

Research paper thumbnail of Rate of recurrence in Indian patients presenting with acute pancreatitis and identification of chronicity on follow up: Possible risk factors for progression

Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology, Mar 7, 2018

To study the profile and long-term outcome of Indian patients presenting with acute pancreatitis ... more To study the profile and long-term outcome of Indian patients presenting with acute pancreatitis and the possible risk factors for progression. Consecutive patients with acute or recurrent acute pancreatitis seen in our department during July 2013 to December 2014 were included. Details of past episodes were collected and patients were followed up till March 2015. In the 97 patients included (mean age 47.2 [SD 16.9] years; 74 men), gallstones (37 [38.1%]) and alcohol (19 [19.6%]) were the major identified etiologies; the idiopathic (31 [32%]) group constituted a third of patients. Recurrences were more common with idiopathic etiology (14 patients out of 30 had recurrences [46.7%]) as compared to alcoholic (5 out of 19 [26.3%]) and biliary (4 out of 37 [10.8%]) pancreatitis and with mild index episode. Following the episode of acute pancreatitis, identification of chronic pancreatitis was more common with alcoholic (6 out of 18 [33%]) and idiopathic (9 out of 30 [30%]) etiology as co...

Research paper thumbnail of Temporal change in phenotypic behaviour in patients with Crohn’s disease: Do Indian patients behave differently from Western and other Asian patients?

Journal of Crohn's and Colitis, 2015

In Western studies, one-third of patients with Crohn&... more In Western studies, one-third of patients with Crohn's disease have stricturing or penetrating disease at presentation and one-half will progress to complicated disease in 20 years. Asian studies indicate that the disease phenotype may be different. Our aim was to study the disease behaviour in Indian patients with Crohn's disease. In this hospital based study, we analysed (Montreal classification) disease phenotype, presence of perianal disease, need for intestinal surgery, and changes in the Montreal classification over time in Crohn's disease patients from our database. In the 178 patients (median age 35, IQR 21 years; 97 males) with Crohn's disease, the proportion of various features: more patients had ileo-colonic(L3: 43.8%) than ileal(L1: 27.5%) or colonic(L2: 28.7%) disease; perianal disease was seen in 11.8% at baseline. Non-stricturing non-fistulising disease(B1) was seen in 74.7%, 65.7%, 50% and 44.4% at baseline, at 5, 10 and 15 years, respectively; stricturing disease(B2) in 21.4%, 21.9%, 28.9% and 33.3%; and penetrating disease(B3) in 3.9%, 11.4%, 21% and 16.7%, intestinal surgery required in 10.7%, 20%, 34.2% and 55.5% respectively. Kaplan-Meier analysis showed no association between progression of disease and patient age and location of the disease. Gender distribution and predominant ileo-colonic location of disease were similar to earlier Asian reports on Crohn's disease. Perianal disease was less frequent than reported in Western and other Asian studies. One-fourth of Indian patients had aggressive disease at diagnosis, but the tendency to progress towards aggressive disease over time was less pronounced than in Western patients.