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Papers by Vyacheslav Dushenkov
AVICENNA BULLETIN
Objective: To assess the potential role of botanicals as therapeutic agents against the SARS-CoV-... more Objective: To assess the potential role of botanicals as therapeutic agents against the SARS-CoV-2 virus. Methods: This narrative review examined the potential role of botanicals as therapeutic agents against the SARS-CoV-2 virus based on the references limited to the English language and published up to February 2022 and retrieved from common academic search engines using multiple keywords and their combinations. The scientific names of plant species were confirmed using World Flora Online (https://wfoplantlist.org/). Results: The role of botanicals in targeting druggable points in the virus replication cycle has been evaluated. This includes the potential role of phytochemicals and medicinal plant concoctions in preventing the virus from entering the cell. Furthermore, the agents have been shown to hinder the attachment of S protein to angiotensin-converting enzyme 2, block RNA-dependent RNA Polymerase, inhibit 3-chymotrypsin like protease, main protease, neuraminidase, and other ...
Zoologicheskii Zhurnal, 1989
Novel acetylated flavonoid glycosides from the leaves of Allium ursinum
The American Biology Teacher, 1993
Environmental Science & Technology, 1997
Phytoremediation is emerging as a potential cost-effective solution for the remediation of contam... more Phytoremediation is emerging as a potential cost-effective solution for the remediation of contaminated soils. Because contaminants such as lead (Pb) have limited bioavailability in the soil, a means of solubilizing the Pb in the soil and facilitating its transport to the shoots of plants is vital to the success of phytoremediation. Indian mustard (Brassica juncea) was used to demonstrate the capability of plants to accumulate high tissue concentrations of Pb when grown in Pb-contaminated soil. Concentrations of 1.5% Pb in the shoots of B. juncea were obtained from soils containing 600 mg of Pb/kg amended with synthetic chelates such as EDTA. The accumulation of Pb in the tissue corresponded to the concentration of Pb in the soil and the concentration of EDTA added to the soil. The accumulation of Cd, Cu, Ni, and Zn from contaminated soil amended with EDTA and other synthetic chelators was also demonstrated. The research indicates that the accumulation of metal in the shoots of B. juncea can be enhanced through the application of synthetic chelates to the soil, facilitating high biomass accumulation as well as metal uptake.
Environmental Science & Technology, 1995
Heavy metal pollution of water is a major environmental problem facing the modern world. Rhizofil... more Heavy metal pollution of water is a major environmental problem facing the modern world. Rhizofiltration-the use of plant roots to remove heavy metals from water-is an emerging environmental cleanup technology. Roots of many hydroponically grown terrestrial plants, e.g., Indian mustard (Brassica juncea (L.) Czern.), sunflower (Helianthus annuus L.), and various grasses, effectively removed toxic metals such as Cu2+, Cd2+, C P , Ni2+, Pb2+, and Zn2+ from aqueous solutions. Roots of B, juncea concentrated these metals 131-563-fold (on a DW basis) above initial solution concentrations. Pb removal was based on tissue absorption and on root-mediated Pb precipitation in the form of insoluble inorganic compounds, mainly lead phosphate. At high Pb concentrations, precipitation played a progressively more important role in Pb removal than tissue absorption, which saturated at approximately 100 mg of Pb/g DW root. Dried roots were much less effective than live roots in accumulating Pb and in removing Pb from the solution.
Environmental Science & Technology, 1995
Heavy metals concentration is increasing day by day due to the activities of the human. Due to th... more Heavy metals concentration is increasing day by day due to the activities of the human. Due to this increment heavy metals create serious problems to the survival of the organism on the earth. So this is a need of the environment to protect or conserve it from different problems by using different techniques. Phytoextraction is the widely use application of plant in Environmental Biology. This technique was getting more attention for the hyper accumulation of heavy metals in the plants. Plants were good source for the removal of heavy metals from the soil. In this review the use of plant, some important plants which were used in Phytoextraction, pollution of soil causes by heavy metals, effects of heavy metals specially Cadmium and Lead and the mechanism of uptake and adsorption of heavy metals by the plants was studied. Further studies are required in this field to find out other techniques and also the fixation of the plant which are used in this process. Because the organic contaminants, cannot be degraded easily.
Current Opinion in Biotechnology, 1994
Abstract Certain plants can concentrate essential and non-essential heavy metals in their roots a... more Abstract Certain plants can concentrate essential and non-essential heavy metals in their roots and shoots to levels far exceeding those present in the soil. Metal-accumulating plant species are invariably restricted to metalliferous soils found in different regions around the ...
DNA barcoding was performed for four medicinal plant species from the mountain region of Tajikist... more DNA barcoding was performed for four medicinal plant species from the mountain region of Tajikistan. The nucleotide sequences for Artemisia sieberi, Artemisia scoparia, Artemisia vulgaris, and Nepeta glutinosa were deposited into the GenBank at the National Center for Biotechnology Information
A prospective observational study was conducted at three ophthalmic clinics to assess the clinica... more A prospective observational study was conducted at three ophthalmic clinics to assess the clinical patterns and etiology of uveitis in the Central Asia Republic of Tajikistan. All patients underwent physical and ophthalmologic examinations. Extensive efforts were made to determine the etiology of uveitis, including workups for Behçet's Disease (BD) and Vogt–Koyanagi–Harada (VKH) syndrome. All patients were tested for the presence of HLA-B27. Presence and/or history of tuberculosis and syphilis were ruled out. HSV, CMV, Chlamydia trachomatis and HIV antibody titers were determined by ELISA. Uveitis was diagnosed in 51 patient ages 14 to 60 were with women accounted for 60.8%. Bilateral uveitis was presented in 74.5% cases and dominated in all age groups. Seven HLA-B27-positive patients had isolated uveitis without systemic manifestations and five had uveitis associated with spondyloarthritis (SpA). In total, uveitis was associated most commonly with SpA (23.5%), BD (9.8%), and VK...
Endemic medical species Serratula dissecta seeds cryo-conservation problems are considered in thi... more Endemic medical species Serratula dissecta seeds cryo-conservation problems are considered in this report. Optimal conditions of freezing-defrosting for the best germination preservation of biological material were chosen. The biology of freshly Serratula dissecta seeds germination after its deep freezing has been researched. Comparative analysis of original seeds' germination dynamics and germination dynamics after cryo-conservation were carried out. On the basis of these experiments long-term storage conditions of Serratula dissecta seeds were selected.
Virtual microscopy (VM) has been widely available for more than a decade, especially in clinical ... more Virtual microscopy (VM) has been widely available for more than a decade, especially in clinical settings and medical schools. In recent years the movement away from conventional optical microscopy (OM) and towards VM has been accelerating and several VM websites are now available online and readily accessible to educators. VM can enhance the instructor’s ability to teach the histology component of anatomy and physiology classes, facilitate student learning, save time for both students and instructors, and ultimately save money that can be more productively used for other facets of the laboratory. The many pedagogical and practical advantages provided by VM suggest that now is the time for undergraduate anatomy and physiology programs to consider a transition to VM. doi: 10.21692/haps.2017.024
Objective: То study of antibacterial, antifungal and antioxidant activity, and content of polyphe... more Objective: То study of antibacterial, antifungal and antioxidant activity, and content of polyphenols in the bulb and aerial parts of an endemic species of onion A. schugnanicum. Methods: An ethanol-based extract was prepared from fresh plants. Total polyphenolic content (Folin) and ABTS antioxidant capacity assays were used to characterized extracts. Extracts obtained from bulbs, peduncle, and seeds demonstrated antibacterial activity against the reference Staphylococcus aureus (ATCC 4929), Pseudomonas aeruginosa (ATCC 4930) and Klebsiella pneumoniae (ATCC 4927) strains, as well as against the hospital strains of the same types of bacteria, i.e. strains isolated from inpatient surgical patients. Results: The study found that ethanol extracts obtained from all organs of A. schugnanicum exhibit high inhibitory activity against the hospital and reference strains. In relation to reference then to hospital strains ethanol extracts were more active. The greatest bactericidal effect on bo...
Objectives: The fast-rising rate of diabetes incidents is a growing concern in Central Asian coun... more Objectives: The fast-rising rate of diabetes incidents is a growing concern in Central Asian countries. This article reviews the current understanding of type 2 diabetes etiology, progression and treatment options along with opportunities for utilizing Avicenna's legacy in developing novel botanical therapeutics. Methods: Analysis of relevant publications, including a variety of Avicenna's work in Arabic, English and Russian. Results: With conventional treatment strategy shifting from single-component drugs aimed at one target to multitherapeutic combinations addressing the complex nature of many diseases and conditions, the role of multicomponent botanical preparations may increase. Diabetes mellitus is a serious chronic, progressive disease characterized by hyperglycemia, which is associated with a variety of comorbidities because of considerable damage, dysfunction and failure of multiple organs developed through the disease's progression. Multidisciplinary collaborative research that encompasses innovative tools could be used for effective development of new comprehensive therapeutic products and treatments based on knowledge of traditional medicine and supported by contemporary scientific validation. Conclusion: Comprehensive analysis of Avicenna's 1,000-year-old approach to the treatment of prediabetes and diabetes provides valuable directions in the search for plant-based treatments. Botanical therapeutics may provide relatively inexpensive and safe methods for diabetes treatment.
AVICENNA BULLETIN
Objective: To assess the potential role of botanicals as therapeutic agents against the SARS-CoV-... more Objective: To assess the potential role of botanicals as therapeutic agents against the SARS-CoV-2 virus. Methods: This narrative review examined the potential role of botanicals as therapeutic agents against the SARS-CoV-2 virus based on the references limited to the English language and published up to February 2022 and retrieved from common academic search engines using multiple keywords and their combinations. The scientific names of plant species were confirmed using World Flora Online (https://wfoplantlist.org/). Results: The role of botanicals in targeting druggable points in the virus replication cycle has been evaluated. This includes the potential role of phytochemicals and medicinal plant concoctions in preventing the virus from entering the cell. Furthermore, the agents have been shown to hinder the attachment of S protein to angiotensin-converting enzyme 2, block RNA-dependent RNA Polymerase, inhibit 3-chymotrypsin like protease, main protease, neuraminidase, and other ...
Zoologicheskii Zhurnal, 1989
Novel acetylated flavonoid glycosides from the leaves of Allium ursinum
The American Biology Teacher, 1993
Environmental Science & Technology, 1997
Phytoremediation is emerging as a potential cost-effective solution for the remediation of contam... more Phytoremediation is emerging as a potential cost-effective solution for the remediation of contaminated soils. Because contaminants such as lead (Pb) have limited bioavailability in the soil, a means of solubilizing the Pb in the soil and facilitating its transport to the shoots of plants is vital to the success of phytoremediation. Indian mustard (Brassica juncea) was used to demonstrate the capability of plants to accumulate high tissue concentrations of Pb when grown in Pb-contaminated soil. Concentrations of 1.5% Pb in the shoots of B. juncea were obtained from soils containing 600 mg of Pb/kg amended with synthetic chelates such as EDTA. The accumulation of Pb in the tissue corresponded to the concentration of Pb in the soil and the concentration of EDTA added to the soil. The accumulation of Cd, Cu, Ni, and Zn from contaminated soil amended with EDTA and other synthetic chelators was also demonstrated. The research indicates that the accumulation of metal in the shoots of B. juncea can be enhanced through the application of synthetic chelates to the soil, facilitating high biomass accumulation as well as metal uptake.
Environmental Science & Technology, 1995
Heavy metal pollution of water is a major environmental problem facing the modern world. Rhizofil... more Heavy metal pollution of water is a major environmental problem facing the modern world. Rhizofiltration-the use of plant roots to remove heavy metals from water-is an emerging environmental cleanup technology. Roots of many hydroponically grown terrestrial plants, e.g., Indian mustard (Brassica juncea (L.) Czern.), sunflower (Helianthus annuus L.), and various grasses, effectively removed toxic metals such as Cu2+, Cd2+, C P , Ni2+, Pb2+, and Zn2+ from aqueous solutions. Roots of B, juncea concentrated these metals 131-563-fold (on a DW basis) above initial solution concentrations. Pb removal was based on tissue absorption and on root-mediated Pb precipitation in the form of insoluble inorganic compounds, mainly lead phosphate. At high Pb concentrations, precipitation played a progressively more important role in Pb removal than tissue absorption, which saturated at approximately 100 mg of Pb/g DW root. Dried roots were much less effective than live roots in accumulating Pb and in removing Pb from the solution.
Environmental Science & Technology, 1995
Heavy metals concentration is increasing day by day due to the activities of the human. Due to th... more Heavy metals concentration is increasing day by day due to the activities of the human. Due to this increment heavy metals create serious problems to the survival of the organism on the earth. So this is a need of the environment to protect or conserve it from different problems by using different techniques. Phytoextraction is the widely use application of plant in Environmental Biology. This technique was getting more attention for the hyper accumulation of heavy metals in the plants. Plants were good source for the removal of heavy metals from the soil. In this review the use of plant, some important plants which were used in Phytoextraction, pollution of soil causes by heavy metals, effects of heavy metals specially Cadmium and Lead and the mechanism of uptake and adsorption of heavy metals by the plants was studied. Further studies are required in this field to find out other techniques and also the fixation of the plant which are used in this process. Because the organic contaminants, cannot be degraded easily.
Current Opinion in Biotechnology, 1994
Abstract Certain plants can concentrate essential and non-essential heavy metals in their roots a... more Abstract Certain plants can concentrate essential and non-essential heavy metals in their roots and shoots to levels far exceeding those present in the soil. Metal-accumulating plant species are invariably restricted to metalliferous soils found in different regions around the ...
DNA barcoding was performed for four medicinal plant species from the mountain region of Tajikist... more DNA barcoding was performed for four medicinal plant species from the mountain region of Tajikistan. The nucleotide sequences for Artemisia sieberi, Artemisia scoparia, Artemisia vulgaris, and Nepeta glutinosa were deposited into the GenBank at the National Center for Biotechnology Information
A prospective observational study was conducted at three ophthalmic clinics to assess the clinica... more A prospective observational study was conducted at three ophthalmic clinics to assess the clinical patterns and etiology of uveitis in the Central Asia Republic of Tajikistan. All patients underwent physical and ophthalmologic examinations. Extensive efforts were made to determine the etiology of uveitis, including workups for Behçet's Disease (BD) and Vogt–Koyanagi–Harada (VKH) syndrome. All patients were tested for the presence of HLA-B27. Presence and/or history of tuberculosis and syphilis were ruled out. HSV, CMV, Chlamydia trachomatis and HIV antibody titers were determined by ELISA. Uveitis was diagnosed in 51 patient ages 14 to 60 were with women accounted for 60.8%. Bilateral uveitis was presented in 74.5% cases and dominated in all age groups. Seven HLA-B27-positive patients had isolated uveitis without systemic manifestations and five had uveitis associated with spondyloarthritis (SpA). In total, uveitis was associated most commonly with SpA (23.5%), BD (9.8%), and VK...
Endemic medical species Serratula dissecta seeds cryo-conservation problems are considered in thi... more Endemic medical species Serratula dissecta seeds cryo-conservation problems are considered in this report. Optimal conditions of freezing-defrosting for the best germination preservation of biological material were chosen. The biology of freshly Serratula dissecta seeds germination after its deep freezing has been researched. Comparative analysis of original seeds' germination dynamics and germination dynamics after cryo-conservation were carried out. On the basis of these experiments long-term storage conditions of Serratula dissecta seeds were selected.
Virtual microscopy (VM) has been widely available for more than a decade, especially in clinical ... more Virtual microscopy (VM) has been widely available for more than a decade, especially in clinical settings and medical schools. In recent years the movement away from conventional optical microscopy (OM) and towards VM has been accelerating and several VM websites are now available online and readily accessible to educators. VM can enhance the instructor’s ability to teach the histology component of anatomy and physiology classes, facilitate student learning, save time for both students and instructors, and ultimately save money that can be more productively used for other facets of the laboratory. The many pedagogical and practical advantages provided by VM suggest that now is the time for undergraduate anatomy and physiology programs to consider a transition to VM. doi: 10.21692/haps.2017.024
Objective: То study of antibacterial, antifungal and antioxidant activity, and content of polyphe... more Objective: То study of antibacterial, antifungal and antioxidant activity, and content of polyphenols in the bulb and aerial parts of an endemic species of onion A. schugnanicum. Methods: An ethanol-based extract was prepared from fresh plants. Total polyphenolic content (Folin) and ABTS antioxidant capacity assays were used to characterized extracts. Extracts obtained from bulbs, peduncle, and seeds demonstrated antibacterial activity against the reference Staphylococcus aureus (ATCC 4929), Pseudomonas aeruginosa (ATCC 4930) and Klebsiella pneumoniae (ATCC 4927) strains, as well as against the hospital strains of the same types of bacteria, i.e. strains isolated from inpatient surgical patients. Results: The study found that ethanol extracts obtained from all organs of A. schugnanicum exhibit high inhibitory activity against the hospital and reference strains. In relation to reference then to hospital strains ethanol extracts were more active. The greatest bactericidal effect on bo...
Objectives: The fast-rising rate of diabetes incidents is a growing concern in Central Asian coun... more Objectives: The fast-rising rate of diabetes incidents is a growing concern in Central Asian countries. This article reviews the current understanding of type 2 diabetes etiology, progression and treatment options along with opportunities for utilizing Avicenna's legacy in developing novel botanical therapeutics. Methods: Analysis of relevant publications, including a variety of Avicenna's work in Arabic, English and Russian. Results: With conventional treatment strategy shifting from single-component drugs aimed at one target to multitherapeutic combinations addressing the complex nature of many diseases and conditions, the role of multicomponent botanical preparations may increase. Diabetes mellitus is a serious chronic, progressive disease characterized by hyperglycemia, which is associated with a variety of comorbidities because of considerable damage, dysfunction and failure of multiple organs developed through the disease's progression. Multidisciplinary collaborative research that encompasses innovative tools could be used for effective development of new comprehensive therapeutic products and treatments based on knowledge of traditional medicine and supported by contemporary scientific validation. Conclusion: Comprehensive analysis of Avicenna's 1,000-year-old approach to the treatment of prediabetes and diabetes provides valuable directions in the search for plant-based treatments. Botanical therapeutics may provide relatively inexpensive and safe methods for diabetes treatment.