Mridul Soni | Himachal Pradesh University.Shimla (original) (raw)
Papers by Mridul Soni
Cureus, Feb 11, 2023
Introduction: Anemia among pregnant women is one of the major health concerns for healthcare work... more Introduction: Anemia among pregnant women is one of the major health concerns for healthcare workers. The management becomes a concern in the pregnancy where the question arises of which is better the intravenous iron sucrose or the oral ferrous sulfate tablets. To answer this, a randomized control trial comparing both the treatment options in a tertiary care government hospital was set up in the hilly terrains of India. This study discusses the effectiveness and practical aspect of using both, which seems to be the better out of both, and why. Methods: The study was conducted as a parallel-group, open-label randomized controlled trial (RCT) in the Department of Obstetrics and Gynecology of a tertiary care government hospital in India, with approximately 4,000 delivery loads annually. Ethical clearance was obtained from the institute's ethics committee (IEC), and the trial was registered with the Clinical Trial Registry of India (REF/2022/06/055013). Two hundred sixty-eight pregnant women between 18 and 45 years of age with moderate iron deficiency anemia (IDA) (hemoglobin (Hb) 7-9g/dl, microcytic-hypochromic, and serum ferritin <30ng/ml) were included in the study. Patients were randomly divided into two groups: group 1 with 134 patients to receive intravenous iron sucrose and group 2 with 134 patients to receive oral ferrous sulfate tablets. Results: The intravenous iron sucrose is superior in terms of tolerability and correction of iron deficiency anemia during pregnancy. Conclusion: It yields a quicker rise in Hb and serum ferritin with no major side effects. In the difficult terrain of Himachal Pradesh, this makes IV iron sucrose a better option for anemic pregnant women who do not have easy access to health facilities resulting in a large number of them reaching hospitals with moderate to severe anemia at a later gestation.
Cureus, Nov 17, 2022
An uncommon malformation of the female genital system is the transverse septum which is often kno... more An uncommon malformation of the female genital system is the transverse septum which is often known as the vaginal septum. A problem with the union and channelling of the Mullerian conductors and urogenital sinus is the primary common cause of progressive pathogenesis. This anatomical blockage can block the vagina, which can lead to a hematocolpos that is connected with periodic pelvic discomfort in teenage females immediately after menarche. A thorough clinical gynaecological evaluation, particularly an abdominal or transrectal ultrasound scan, and in even more complicated situations, magnetic resonance imaging is used to determine the presence of a vaginal septum. The surgical intervention must be performed as soon as feasible. We report the management of a case of a 16-year-old girl presented with primary amenorrhea associated with severe pain in the lower abdomen for 2-3 days, which was cyclic in nature and spasmodic in character. She revealed a hematocolpos during the examination, aggravating a full transverse vaginal septum. Removing the hematocolpos and examining the cervix were the steps in the therapy.
International Journal of Contemporary Pediatrics
The development of multiple sclerosis in children provides to have prophylactic and treatment pro... more The development of multiple sclerosis in children provides to have prophylactic and treatment problems, especially if the manifestations of the initial demyelinating episode mirror the acute disseminated encephalomyelitis. This disease which was once considered a rare occurrence has started to show more cases in the last few years. Magnetic resonance imaging seems to be an excellent diagnostic technique but it is limited because of the accuracy to identify acute disseminated encephalomyelitis from the initial bout of multiple sclerosis. Sophisticated magnetic resonance imaging methods could provide the needed precision to identify if the degradation and consistency of non-lesional matter can be differentiated for what happens as a core hallmark of multiple sclerosis. Even though the development of multiple sclerosis in infancy often forecasts a positive short-term outcome, several children become seriously impaired, whether physically or intellectually, and much more than fifty perc...
Pediatrics & Therapeutics, 2021
Cureus, 2021
Acromegaly is a complex endocrinological disorder commonly caused by hypersecretion of growth hor... more Acromegaly is a complex endocrinological disorder commonly caused by hypersecretion of growth hormone (GH) typically due to pituitary gland tumors. Patients with acromegaly who are successfully treated and biochemically managed have a reasonably average life expectancy. However, it causes a cascade of multi-systemic involvement throughout the patient’s life, including cardiovascular, neuropsychiatric, respiratory, metabolic, neurological, neoplastic, and gastrointestinal involvement, resulting in a higher rate of hospitalization, lower quality of life, and a shorter life expectancy. Although cardiovascular complications are the primary cause of death in patients with acromegaly, malignancy is now emerging as a major killer in these individuals. Colorectal carcinoma has been reported to be prevalent in acromegaly individuals. This review article has compiled studies to demonstrate a link between acromegaly and colorectal neoplasia, intending to provide a strong foundation for their c...
Cureus, Feb 11, 2023
Introduction: Anemia among pregnant women is one of the major health concerns for healthcare work... more Introduction: Anemia among pregnant women is one of the major health concerns for healthcare workers. The management becomes a concern in the pregnancy where the question arises of which is better the intravenous iron sucrose or the oral ferrous sulfate tablets. To answer this, a randomized control trial comparing both the treatment options in a tertiary care government hospital was set up in the hilly terrains of India. This study discusses the effectiveness and practical aspect of using both, which seems to be the better out of both, and why. Methods: The study was conducted as a parallel-group, open-label randomized controlled trial (RCT) in the Department of Obstetrics and Gynecology of a tertiary care government hospital in India, with approximately 4,000 delivery loads annually. Ethical clearance was obtained from the institute's ethics committee (IEC), and the trial was registered with the Clinical Trial Registry of India (REF/2022/06/055013). Two hundred sixty-eight pregnant women between 18 and 45 years of age with moderate iron deficiency anemia (IDA) (hemoglobin (Hb) 7-9g/dl, microcytic-hypochromic, and serum ferritin <30ng/ml) were included in the study. Patients were randomly divided into two groups: group 1 with 134 patients to receive intravenous iron sucrose and group 2 with 134 patients to receive oral ferrous sulfate tablets. Results: The intravenous iron sucrose is superior in terms of tolerability and correction of iron deficiency anemia during pregnancy. Conclusion: It yields a quicker rise in Hb and serum ferritin with no major side effects. In the difficult terrain of Himachal Pradesh, this makes IV iron sucrose a better option for anemic pregnant women who do not have easy access to health facilities resulting in a large number of them reaching hospitals with moderate to severe anemia at a later gestation.
Cureus, Nov 17, 2022
An uncommon malformation of the female genital system is the transverse septum which is often kno... more An uncommon malformation of the female genital system is the transverse septum which is often known as the vaginal septum. A problem with the union and channelling of the Mullerian conductors and urogenital sinus is the primary common cause of progressive pathogenesis. This anatomical blockage can block the vagina, which can lead to a hematocolpos that is connected with periodic pelvic discomfort in teenage females immediately after menarche. A thorough clinical gynaecological evaluation, particularly an abdominal or transrectal ultrasound scan, and in even more complicated situations, magnetic resonance imaging is used to determine the presence of a vaginal septum. The surgical intervention must be performed as soon as feasible. We report the management of a case of a 16-year-old girl presented with primary amenorrhea associated with severe pain in the lower abdomen for 2-3 days, which was cyclic in nature and spasmodic in character. She revealed a hematocolpos during the examination, aggravating a full transverse vaginal septum. Removing the hematocolpos and examining the cervix were the steps in the therapy.
International Journal of Contemporary Pediatrics
The development of multiple sclerosis in children provides to have prophylactic and treatment pro... more The development of multiple sclerosis in children provides to have prophylactic and treatment problems, especially if the manifestations of the initial demyelinating episode mirror the acute disseminated encephalomyelitis. This disease which was once considered a rare occurrence has started to show more cases in the last few years. Magnetic resonance imaging seems to be an excellent diagnostic technique but it is limited because of the accuracy to identify acute disseminated encephalomyelitis from the initial bout of multiple sclerosis. Sophisticated magnetic resonance imaging methods could provide the needed precision to identify if the degradation and consistency of non-lesional matter can be differentiated for what happens as a core hallmark of multiple sclerosis. Even though the development of multiple sclerosis in infancy often forecasts a positive short-term outcome, several children become seriously impaired, whether physically or intellectually, and much more than fifty perc...
Pediatrics & Therapeutics, 2021
Cureus, 2021
Acromegaly is a complex endocrinological disorder commonly caused by hypersecretion of growth hor... more Acromegaly is a complex endocrinological disorder commonly caused by hypersecretion of growth hormone (GH) typically due to pituitary gland tumors. Patients with acromegaly who are successfully treated and biochemically managed have a reasonably average life expectancy. However, it causes a cascade of multi-systemic involvement throughout the patient’s life, including cardiovascular, neuropsychiatric, respiratory, metabolic, neurological, neoplastic, and gastrointestinal involvement, resulting in a higher rate of hospitalization, lower quality of life, and a shorter life expectancy. Although cardiovascular complications are the primary cause of death in patients with acromegaly, malignancy is now emerging as a major killer in these individuals. Colorectal carcinoma has been reported to be prevalent in acromegaly individuals. This review article has compiled studies to demonstrate a link between acromegaly and colorectal neoplasia, intending to provide a strong foundation for their c...