rashmikaul raina | Himachal Pradeh University (original) (raw)

Papers by rashmikaul raina

JOJ nursing & health care, 2017

PubMed, May 2, 2017

A case of visceral leishmaniasis (VL)-associated hemophagocytic lymphohistiocytosis (HLH) in an i... more A case of visceral leishmaniasis (VL)-associated hemophagocytic lymphohistiocytosis (HLH) in an immunocompetent native from a nonendemic area was reported. The patient belonged to Ravi river valley area (altitude 996 meters above the mean sea level) of Chamba, Himachal Pradesh, India. VL and HLH were not a differential diagnosis. Identification of the Leishman-Donovan bodies and hemophagocytosis in bone marrow aspirate and biopsy provided the diagnosis. The patient recovered to the treatment with amphotericin B.

Indian Journal of Dermatology, 2016

A 32-year-old male presented to Dermatology outpatient Department with complaints of a single non... more A 32-year-old male presented to Dermatology outpatient Department with complaints of a single nonhealing ulcer on his right thigh. This lesion was there for the last 1΍ months. It had begun as a small nodule and increased up to the present size of 3 cm with an oozing and ulcerated surface and thickened everted margins. The systemic investigations were normal which included hemogram, biochemistry, including liver and renal function tests, chest X-ray, ultrasonography of abdomen, computed tomography of the thorax, and abdomen. Skin biopsy revealed multiple rounds to oval spores with surrounding halo intracellularly as well as extracellularly. A diagnosis of deep fungal infection as histoplasmosis was made and confirmed on culture.

Recent Advances in Biology and Medicine, 2016

New-onset pancytopenia is a common diagnostic challenge. Pancytopenia is an indication for bone m... more New-onset pancytopenia is a common diagnostic challenge. Pancytopenia is an indication for bone marrow examination. The present study has been carried out to determine the frequencies of various etiologies of pancytopenia based on bone marrow morphology in a defined geographical location. All cases of new-onset pancytopenia, diagnosed on peripheral smear and seen over a four-year period from January 2012 to December 2015 in the department of pathology, were analysed. Patients lacking representative bone marrow in the aspirate or receiving chemotherapy were excluded. Out of 69 cases, 29 were males and 40 were females. Most of the patients were in the age group of 19-60 years (52.2%). Nineteen (26.1%) of them were less than 18 years old. The three major causes of pancytopenia were: megaloblastic anemia (hypercellular marrow with megaloblastic erythropoiesis) in 25 (36.2%) cases, hypercellular marrow with dimorphic erythropoiesis in 13 (18.8%) cases, and haematological malignancies in 12 (17.4%) cases of the study. Bone marrow examination along with laboratory evaluation helps to establish specific diagnosis in cases of new-onset pancytopenia.

Egyptian Rheumatology and Rehabilitation, Oct 1, 2014

We report a case of a 33-year-old woman who presented to us with symptoms of bronchial asthma and... more We report a case of a 33-year-old woman who presented to us with symptoms of bronchial asthma and peripheral neuropathy. After investigations, the diagnosis of eosinophilic granulomatosis and polyangitis (Churg-Strauss syndrome) was made.

Recent Advances in Biology and Medicine, Jun 30, 2022

The cytological examinations of serous effusions have been well-accepted, and a positive diagnosi... more The cytological examinations of serous effusions have been well-accepted, and a positive diagnosis is often considered a definitive diagnosis. The study was planned to determine the diagnostic utility of fluid cytology by conventional smear and cell block method in pleural effusion. This was a hospital-based open cohort observational study conducted on patients diagnosed with pleural effusion. The study period was one year, and patients were recruited using a nonprobability sampling method. The fluid samples were subjected to the conventional smear examination, followed by cell block preparation. The overall morphologic details, cellularity, architecture, and nuclear and cytoplasmic details were studied and compared in conventional smear and cell block techniques. The samples were categorized as unsatisfactory, benign, suspicious for malignancy, or malignancy. The study was conducted on 113 pleural fluid samples. The study demonstrated that the cell block technique improved the cellular yield and established diagnosis in malignant effusions.

International Journal of Reproduction, Contraception, Obstetrics and Gynecology, 2017

Background: Ovarian tumors are one of the ubiquitous and common forms of neoplasms in women. The ... more Background: Ovarian tumors are one of the ubiquitous and common forms of neoplasms in women. The aim of the study was to understand the pattern of benign and malignant ovarian neoplasms and their distribution in different age groups in rural population of India.Methods: A retrospective study conducted in the Department of Pathology in close collaboration with Department of Obstetrics and Gynecology, Dr. Rajendra Prasad Government Medical College, Kangra at Tanda (HP), India. All the patients irrespective of age group who were operated for ovarian neoplasms (benign or malignant) were included in this retrospective analysis over duration of four years (2013 to 2016). “WHO classification system” was used, for classification of all these ovarian tumors. The incidence of these tumors with respect to age group was also studied.Results: During the study period (2013-2016), there were a total of 242 surgeries for ovarian neoplasms. Of these, majority of the tumours were benign 184 (76%), bu...

Background: Lymphadenopathy (LAP) is a common clinical presentation seen in pediatric patients at... more Background: Lymphadenopathy (LAP) is a common clinical presentation seen in pediatric patients attending the outpatient department. The etiology of LAP varies from a benign process to malignancy. Fine needle aspiration cytology (FNAC) is a very rapid and easy to perform diagnostic test. Majority of cases can be diagnosed and managed on FNAC without need of histopathology. The aim of this study was to evaluate the role of FNAC in diagnosis of superficial LAP in pediatric population. Methods: This retrospective study was carried out over a period of two years from January 2015 to December 2016 in the department of Pathology, Dr. RPGMC, Tanda, Himachal Pradesh, India. All cases of superficial LAP seen in pediatric population where FNAC was performed were included in the study. Results: A total of 357 lymph nodes were aspirated in pediatric population during the study period. Majority of cases (98%) were benign. The results were categorized into three broad categories as reactive lympha...

The Journal of the Association of Physicians of India, 2017

We report a case of visceral leishmaniasis (VL) in an immunocompetent native from non-endemic reg... more We report a case of visceral leishmaniasis (VL) in an immunocompetent native from non-endemic region of India that presented with chronic diarrhoea. VL was not a differential diagnosis and was unexpectedly diagnosed as intestinal leishmaniasis through the identification of the Leishman-Donovan (LD) bodies in duodenal and colonic mucosa. The patient expired before receiving antileishmanial therapy.

Journal of Laboratory Physicians, 2016

ABSTRACTHeterotopic pancreatic tissue in the gall bladder is an uncommon incidental finding in mo... more ABSTRACTHeterotopic pancreatic tissue in the gall bladder is an uncommon incidental finding in most cases. We hereby describe the case of a 45-year-old woman who presented with symptoms of acalculous cholecystitis. Pathological examination detected heterotopic pancreatic tissue, pseudopyloric metaplasia, and adenomyomatous hyperplasia in the gall bladder. This is a rare combination of three entities which is being reported for the first time. This case emphasizes that heterotopic pancreas might be the causative factor for cholecystitis.

Journal of Cytology, 2014

Background: Abnormal uterine bleeding (AUB) is a common problem for which women seek gynecologica... more Background: Abnormal uterine bleeding (AUB) is a common problem for which women seek gynecological consultation. Endometrial aspiration cytology (EAC) is an acceptable and valuable diagnostic procedure for screening the endometrial status. The purpose of our study was to describe the spectrum of endometrial lesions along with their cytomorphological features as well as to compare the results of EAC with histopathology of the endometrial curettings obtained as a result of dilatation and curettage (D and C), in order to assess the value of the former and its shortcomings. Materials and Methods: Endometrial aspiration using a menstrual regulation (MR) syringe and a 4 mm Karman's cannula was performed just prior to D and C in 100 women presenting with AUB. Smears were reviewed for cytomorphological findings and were correlated with the histopathological findings. These findings were categorized as benign endometrium, endometrial hyperplasia, malignancy and inadequate smears. Results: Age of the patients ranged from 19 to 70 years. In our study, the accuracy in diagnosing benign conditions of endometrium, hyperplasia, and malignancy on aspiration cytology were 93.88%, 96.94% and 96.84%, respectively. Conclusions: Endometrial aspiration is an effective, useful and a minimally invasive procedure. With an experienced cytologist, it can be used routinely for the primary investigation of women with AUB, provided all the points of discrepancies are taken care of.

Indian Journal of Surgery, 2010

The role of hormone receptors as a prognostic and therapeutic tool in breast cancer is widely acc... more The role of hormone receptors as a prognostic and therapeutic tool in breast cancer is widely accepted. The frequency of nonreactivity of estrogen and progesterone receptors in breast cancer patients of India is much more common than in the West. This study was conducted with the aim of analysis of steroid receptor status in breast cancer with clinico-pathological characteristics from the northern hilly state of Himachal Pradesh, India located in the region of the Western Himalayas. Fifty five consecutive patients with the diagnosis of breast cancer were included in this study. Detailed clinical and histopathologic data was recorded in all cases. Estrogen receptor and progesterone receptor status was evaluated by immunohistochemistry. Chi-square test was used for statistical analysis. On immunohistochemical staining, 34.5% cases proved to be estrogen receptor positive and 36.4% cases progesterone receptor positive. The results in the present study documented low estrogen receptor and progesterone receptor positivity in breast cancer from this region of India.

JK Science: Journal of Medical Education & …, 2009

Leishmaniasis, though widely prevalent in South Asia, is not seen in the Kashmir valley where the... more Leishmaniasis, though widely prevalent in South Asia, is not seen in the Kashmir valley where the cold climatic conditions create a hostile environment for the growth of the parasite or its vector, the sandfly. However, a few cases of cutaneous leishmaniasis have been documented from the hot and arid Uri belt of Kashmir. We present a case of visceral leishmaniasis in a boy hailing from Uri, a rarity in this region.

Journal of Laboratory Physicians, 2011

Vyas and Shah: Case report on visceral leishmaniasis Recent outbreaks of VL in India and the epid... more Vyas and Shah: Case report on visceral leishmaniasis Recent outbreaks of VL in India and the epidemic of HIV have made VL a re-emerging problem in India. [4] Outbreaks and epidemics of leishmaniasis have also been associated with urban development, deforestation, environmental changes and population migrations. [5]

Cytopathology, 2004

In this study, we evaluated the usefulness of fine needle aspiration cytology (FNAC) in the diagn... more In this study, we evaluated the usefulness of fine needle aspiration cytology (FNAC) in the diagnosis of soft tissue tumours. We have also assessed the various pitfalls of FNAC of soft tissue tumours. This was a retrospective study and here we analysed only 82 histopathology proven cases of FNAC of soft tissue tumours diagnosed in a five and half year period. On histopathological examination, 55 of these cases were malignant and 27 were benign. There was a total of 15 recurrences and histopathology was available prior to FNAC in only eight of these cases. Therefore, excluding these eight cases, malignant tumours were primarily diagnosed by FNAC in 47 cases. The sensitivity, specificity and positive predictive value of FNAC in diagnosis of soft tissue tumours were 91.5%, 92.5% and 95.5%, respectively. Only 22 of 47 cases (46.8%) were correctly categorized. There were two false‐positive and four false‐negative cases. One case each of fibromatosis and schwannoma were reported as sarcom...

Annals of Pathology and Laboratory Medicine, 2018

Basosquamous carcinoma (BSC) is a rare subtype of basal cell carcinoma (BCC) with an incidence of... more Basosquamous carcinoma (BSC) is a rare subtype of basal cell carcinoma (BCC) with an incidence of 1-2%. BSC is characterized by aggressive nature in terms of poor prognosis and distant metastasis. Unlike BCC which is a rodent ulcer with local invasion and no distant metastasis. BSC is usually diagnosed on histopathology examination after biopsy. We hereby present a case report of diagnosis of BSC on cytological examination followed by confirmation with histopathology. To the best of our knowledge, there is the first case reported in literature on this matter. We emphasize the importance of thorough cytological examination so as to suspect and finally confirm this rare entity.

International Journal of Medical and Health Sciences, 2018

Gestational trophoblastic diseases include complete and partial molar pregnancy, invasive mole, p... more Gestational trophoblastic diseases include complete and partial molar pregnancy, invasive mole, placental site trophoblastic tumor, and choriocarcinoma. The most malignant form is Gestational choriocarcinoma. The present case is an extremely rare case of choriocarcinoma developed after primary complete mole present at the fimbrial end of fallopian tube. Clinical diagnosis was made as ruptured ectopic. Exploratory laprotomy showed a large ulcerative lesion covered with clot present on the posterior aspect of serosal surface of uterus along with numerous grapes like vesicles. On histopathological examination the final diagnosis of extra uterine complete mole transformed into choriocarcinoma was made.

Journal of Vector Borne Diseases, 2018

Background & objectives: In India, certain geographic regions witness simultaneous outbreaks ... more Background & objectives: In India, certain geographic regions witness simultaneous outbreaks of two or more diseases like scrub typhus, dengue fever, malaria, leptospirosis and chikungunya during monsoon and post-monsoon period, sharing common indication of acute febrile illness. The objective of the present study was to assess the prevalence of coinfections among patients with acute undifferentiated fevers (AUF) admitted in a tertiary care hospital in the northern hilly state of Himachal Pradesh, India. Methods: This was a hospital based open cohort study conducted over a period of two months (September and October) in 2016. All the patients above the age of 18 yr admitted in medical wards and fulfilling the definition of AUF were included. The patients diagnosed with dual infections were the subjects of the study. Standard guidelines were used for case definitions of scrub typhus, dengue, chikungunya, malaria and leptospirosis. Results: Dual infections were noted in 16 patients admitted with AUF. The most common coinfection was scrub typhus and dengue, reported in 10 patients. Scrub typhus and leptospirosis coinfection was observed in three patients. Dengue and chikungunya was observed in one patient. Scrub typhus, dengue and vivax malaria was detected in one patient. Scrub typhus and vivax malaria was detected in one patient. Out of the 10 cases positive for both scrub and dengue, four had no history of travel outside Himachal Pradesh. All three cases positive for both scrub and leptospirosis were indigenous without any history of travel outside Kangra, Himachal Pradesh. The outcome of all the patients was with full recovery. Interpretation & conclusion: The study established the presence of coinfections (mainly dengue fever and leptospirosis) as a cause of AUF in the study area, which is a nonendemic region. The role of easily available and widely performed serological tests in the aetiological diagnosis of AUF is significant. Studies are required to determine the normal titres in the local population before using the imported commercially available serological tests in the diagnosis of AUF.