Alyn Morice | University of Hull (original) (raw)
Papers by Alyn Morice
Dextromethorphan Attenuates Capsaicin Induced Cough In Healthy Volunteers
B69. AIRWAY STRUCTURE AND FUNCTION, 2012
Autonomic dysregulation: a mechanism of asthma death
European Respiratory Journal
Cough Suppression By Opiates. Is It Due To Sedation?
D48. CHRONIC COUGH, 2012
Neurological conditions presenting as airway reflux cough
European Respiratory Review, 2012
BMC Family Practice, 2007
Patients may find it difficult to distinguish between the symptoms of anxiety and those of asthma... more Patients may find it difficult to distinguish between the symptoms of anxiety and those of asthma. Findings are equivocal on whether there is a specific link between anxiety and asthma. The aims of this study were to i) to identify the prevalence of anxiety, depression and panic fear in adults with asthma compared with that of the general population ii) to investigate whether there is a specific relationship between asthma and anxiety.
Gender differences in airway behaviour
Thorax, 2000
Trials, Jan 10, 2015
Chronic obstructive pulmonary disease (COPD) is associated with high morbidity, mortality, and he... more Chronic obstructive pulmonary disease (COPD) is associated with high morbidity, mortality, and health-care costs. An incomplete response to the anti-inflammatory effects of inhaled corticosteroids is present in COPD. Preclinical work indicates that 'low dose' theophylline improves steroid responsiveness. The Theophylline With Inhaled Corticosteroids (TWICS) trial investigates whether the addition of 'low dose' theophylline to inhaled corticosteroids has clinical and cost-effective benefits in COPD. TWICS is a randomised double-blind placebo-controlled trial conducted in primary and secondary care sites in the UK. The inclusion criteria are the following: an established predominant respiratory diagnosis of COPD (post-bronchodilator forced expiratory volume in first second/forced vital capacity [FEV1/FVC] of less than 0.7), age of at least 40 years, smoking history of at least 10 pack-years, current inhaled corticosteroid use, and history of at least two exacerbations ...
Developing antitussives the clinician's pipeline-what do we need?
Journal of thoracic disease, 2014
The evolving concept of cough hypersensitivity, an over activity of the afferent sensory nerves i... more The evolving concept of cough hypersensitivity, an over activity of the afferent sensory nerves in the upper airways, has given new insights into the pathophysiology underlying chronic cough. Armed with this new information drug development aimed at reducing cough reflex sensitivity to normal has, for the first time, led to successful clinical studies. This review outlines the concepts underlying the inflammatory processes leading to cough hypersensitivity and demonstrates how knowledge of the molecular pharmacology of hypersensitivity provides a lead into drug targets. Initial hope that antagonists of TRP receptors would reduce clinical cough has been disappointing. Drugs such as theobromine, thalidomide and AF 219 which all have activity on afferent sensory nerves have shown promise in clinical trials. Large-scale phase three clinical studies are required to confirm these exciting findings.
Thorax, 2002
Background: Patients with an acute exacerbation of chronic obstructive pulmonary disease (COPD) w... more Background: Patients with an acute exacerbation of chronic obstructive pulmonary disease (COPD) were randomised to either hospital at home (HaH) or inpatient management, and patient and carer preferred site of management and satisfaction with care received in the two arms was determined.Methods: Emergency admissions with an acute exacerbation of COPD were randomised to inpatient care or HaH care. After discharge
The Lancet Respiratory Medicine, 2013
Predictors of therapy resistant asthma * Authors' reply
Thorax, 2004
Thorax, 2001
... At the highest doses studied for prednisolone (20 mg/day) and fluticasone propionate (2 mg/da... more ... At the highest doses studied for prednisolone (20 mg/day) and fluticasone propionate (2 mg/daynomi-nal dose) there was a 1.5 ... Correspondence to: Professor AH Morice AH MORICE JA KASTELIK I AZIZ Academic Department of Medicine, University of Hull, Castle Hill Hospital ...
The death of academic clinical trials
Lancet, 2003
P13. Nebulized drug delivery: A scintigraphic comparison of two nebulizer systems
Nuclear Medicine Communications, 2000
The Lancet, 2003
There is forward tilting of his torso and hand covering his upper lip.
Collapse with a streptococcal infection
The Lancet, 1999
Cardiac and respiratory related electrical impedance changes in the human thorax
IEEE Transactions on Biomedical Engineering, 1994
Electrical impedance measurements have been made from the human trunk over the frequency range 9.... more Electrical impedance measurements have been made from the human trunk over the frequency range 9.6 kHz to 614 kHz. Measurements have been made from 12 normal subjects and the amplitude of the impedance changes associated with the cardiac and respiratory cycles have been recorded. It was found that the real part of the impedance fell to 64.0% of its low frequency value over the measured range of frequencies and that the changes associated with respiration fell in a similar manner. However, the cardiac related changes fell more rapidly with increasing frequency to 28.2% of the low frequency value. The origin of the measured changes is discussed with a view to understanding why the cardiac related changes fall more rapidly. It is not possible to relate in any simple way the frequency dispersion of a single component to that of the whole trunk. However, the results are consistent with the lungs being the major origin of both the cardiac and respiratory related components. The origin of the cardiac related impedance changes could be the pulsatile volume changes in the pulmonary tree. These could be shunted by nonpulsatile lung tissue that has decreasing impedance at high frequency and thus decreases the relative magnitude of the cardiac related changes. This hypothesis needs to be tested using localized measurements from the thorax and 3-D modeling of the trunk.
Dextromethorphan Attenuates Capsaicin Induced Cough In Healthy Volunteers
B69. AIRWAY STRUCTURE AND FUNCTION, 2012
Autonomic dysregulation: a mechanism of asthma death
European Respiratory Journal
Cough Suppression By Opiates. Is It Due To Sedation?
D48. CHRONIC COUGH, 2012
Neurological conditions presenting as airway reflux cough
European Respiratory Review, 2012
BMC Family Practice, 2007
Patients may find it difficult to distinguish between the symptoms of anxiety and those of asthma... more Patients may find it difficult to distinguish between the symptoms of anxiety and those of asthma. Findings are equivocal on whether there is a specific link between anxiety and asthma. The aims of this study were to i) to identify the prevalence of anxiety, depression and panic fear in adults with asthma compared with that of the general population ii) to investigate whether there is a specific relationship between asthma and anxiety.
Gender differences in airway behaviour
Thorax, 2000
Trials, Jan 10, 2015
Chronic obstructive pulmonary disease (COPD) is associated with high morbidity, mortality, and he... more Chronic obstructive pulmonary disease (COPD) is associated with high morbidity, mortality, and health-care costs. An incomplete response to the anti-inflammatory effects of inhaled corticosteroids is present in COPD. Preclinical work indicates that 'low dose' theophylline improves steroid responsiveness. The Theophylline With Inhaled Corticosteroids (TWICS) trial investigates whether the addition of 'low dose' theophylline to inhaled corticosteroids has clinical and cost-effective benefits in COPD. TWICS is a randomised double-blind placebo-controlled trial conducted in primary and secondary care sites in the UK. The inclusion criteria are the following: an established predominant respiratory diagnosis of COPD (post-bronchodilator forced expiratory volume in first second/forced vital capacity [FEV1/FVC] of less than 0.7), age of at least 40 years, smoking history of at least 10 pack-years, current inhaled corticosteroid use, and history of at least two exacerbations ...
Developing antitussives the clinician's pipeline-what do we need?
Journal of thoracic disease, 2014
The evolving concept of cough hypersensitivity, an over activity of the afferent sensory nerves i... more The evolving concept of cough hypersensitivity, an over activity of the afferent sensory nerves in the upper airways, has given new insights into the pathophysiology underlying chronic cough. Armed with this new information drug development aimed at reducing cough reflex sensitivity to normal has, for the first time, led to successful clinical studies. This review outlines the concepts underlying the inflammatory processes leading to cough hypersensitivity and demonstrates how knowledge of the molecular pharmacology of hypersensitivity provides a lead into drug targets. Initial hope that antagonists of TRP receptors would reduce clinical cough has been disappointing. Drugs such as theobromine, thalidomide and AF 219 which all have activity on afferent sensory nerves have shown promise in clinical trials. Large-scale phase three clinical studies are required to confirm these exciting findings.
Thorax, 2002
Background: Patients with an acute exacerbation of chronic obstructive pulmonary disease (COPD) w... more Background: Patients with an acute exacerbation of chronic obstructive pulmonary disease (COPD) were randomised to either hospital at home (HaH) or inpatient management, and patient and carer preferred site of management and satisfaction with care received in the two arms was determined.Methods: Emergency admissions with an acute exacerbation of COPD were randomised to inpatient care or HaH care. After discharge
The Lancet Respiratory Medicine, 2013
Predictors of therapy resistant asthma * Authors' reply
Thorax, 2004
Thorax, 2001
... At the highest doses studied for prednisolone (20 mg/day) and fluticasone propionate (2 mg/da... more ... At the highest doses studied for prednisolone (20 mg/day) and fluticasone propionate (2 mg/daynomi-nal dose) there was a 1.5 ... Correspondence to: Professor AH Morice AH MORICE JA KASTELIK I AZIZ Academic Department of Medicine, University of Hull, Castle Hill Hospital ...
The death of academic clinical trials
Lancet, 2003
P13. Nebulized drug delivery: A scintigraphic comparison of two nebulizer systems
Nuclear Medicine Communications, 2000
The Lancet, 2003
There is forward tilting of his torso and hand covering his upper lip.
Collapse with a streptococcal infection
The Lancet, 1999
Cardiac and respiratory related electrical impedance changes in the human thorax
IEEE Transactions on Biomedical Engineering, 1994
Electrical impedance measurements have been made from the human trunk over the frequency range 9.... more Electrical impedance measurements have been made from the human trunk over the frequency range 9.6 kHz to 614 kHz. Measurements have been made from 12 normal subjects and the amplitude of the impedance changes associated with the cardiac and respiratory cycles have been recorded. It was found that the real part of the impedance fell to 64.0% of its low frequency value over the measured range of frequencies and that the changes associated with respiration fell in a similar manner. However, the cardiac related changes fell more rapidly with increasing frequency to 28.2% of the low frequency value. The origin of the measured changes is discussed with a view to understanding why the cardiac related changes fall more rapidly. It is not possible to relate in any simple way the frequency dispersion of a single component to that of the whole trunk. However, the results are consistent with the lungs being the major origin of both the cardiac and respiratory related components. The origin of the cardiac related impedance changes could be the pulsatile volume changes in the pulmonary tree. These could be shunted by nonpulsatile lung tissue that has decreasing impedance at high frequency and thus decreases the relative magnitude of the cardiac related changes. This hypothesis needs to be tested using localized measurements from the thorax and 3-D modeling of the trunk.