Seyed Bashir(Bashir) Mirtajani | Islamic Azad University, Lahijan (original) (raw)

Papers by Seyed Bashir(Bashir) Mirtajani

Anesthesiology and Pain Medicine

Desmopressin is an analog of the antidiuretic hormone (vasopressin), which causes anticoagulant a... more Desmopressin is an analog of the antidiuretic hormone (vasopressin), which causes anticoagulant activity by increasing plasma factor 8. The use of desmopressin dates back to 1977, when this hormone was used to prevent bleeding during tooth extraction and surgery in patients with hemophilia A and von Willebrand disease. After that, this hormone was expanded to prevent bleeding in congenital defects and conditions such as chronic kidney and liver failure. Also, this hormone is used to prevent bleeding in major surgeries such as heart surgery, where the patient loses much blood and needs a blood transfusion. Considering the importance of desmopressin in bleeding control, the present study was conducted to investigate the possible effect of this hormone in heart surgery.

Iranian Journal of Clinical Infectious Diseases, Sep 24, 2022

Background: The application of methylprednisolone in ARDS patients has led to a sustained reducti... more Background: The application of methylprednisolone in ARDS patients has led to a sustained reduction in inflammatory plasma cytokines and chemokines and has recently been used in the treatment of patients with SARS-CoV-2 infection. Objectives: In this study, the effect of methylprednisolone on clinical symptoms and antioxidant changes of patients with COVID-19 has been investigated. Methods: In the present study, patients with moderate to severe COVID-19 who required hospitalization were entered into the study phase. Then, in addition to standard treatment, patients received methylprednisolone at a dose of 250 mg intravenously over three days. Necessary evaluations include analysis of arterial blood gases, pulse oximetry, monitoring of patient clinical signs, examination of inflammatory biomarkers, and also receiving 10 cc of peripheral blood samples to check for antioxidant changes, at the beginning of the study, after 24 hours, and 72 hours after receiving methylprednisolone was on the agenda. Results: Changes in fever, superoxide dismutase (SOD, Glutathione-S-Transferase (GST, the ferric reducing ability of plasma (FRAP, malondialdehyde (MDA, Nitric oxide, Ferritin, and TNF-α before treatment and 72 hours after treatment were significantly different between the two stages (P < 0.05). Conclusions: The use of methylprednisolone improves the balance of antioxidants and immunological factors in patients with COVID-19 and thus improves some clinical indicators in these patients.

Journal of Iranian Medical Council

Organoids are a miniature, simplified version of a human organ that are produced in three dimensi... more Organoids are a miniature, simplified version of a human organ that are produced in three dimensions in the laboratory and show the true anatomical array. These organelles originate from one or more cells - embryonic stem cells or induced multipotent stem cells - that can organize themselves in three-dimensional culture media. The use of stem cells due to the unlimited capacity of tissue division and regeneration is a great promise as a therapeutic tool. These three-dimensional models of human tissue can be used to test drugs before they are tested on humans. Lung organoids are one of the different types of organoids that, like other organoids, can be formed through a process of self-organizing stem cells or specific parts of an organ. These organoids can also be utilized as a useful tool for screening drugs and vaccines for infections such as the novel SARS-COV-2 infection. The aim of this study was to investigate the potential of lung organoids in the treatment of pulmonary diseas...

Journal of Iranian Medical Council

Background: Hesperidin is a secondary metabolite of the flavonoid group. Due to its antioxidant, ... more Background: Hesperidin is a secondary metabolite of the flavonoid group. Due to its antioxidant, anti-inflammatory and anti-viral properties, it can be helpful as a treatment option for patients with COVID 19. Methods: This study was conducted as a clinical trial in Masih Daneshvari Hospital in Tehran. After providing complete explanations and obtaining written consent, patients with new coronavirus (COVID-19) were included in the study if they met the inclusion criteria. 20 patients with the new coronavirus (COVID-19) were included in the study. Patients were then randomly divided into hesperidin and control groups. Patients in the hesperidin group received 1 mg of hesperidin orally intravenously every 6 hours for 5 days, whereas in the control group, they did not. Then, the desired variables were measured during the research period. Patients were monitored for adverse drug reactions based on clinical symptoms and signs. The results were evaluated with regard to the design of the ...

Archives of Anesthesia and Critical Care

In the last days of 2019, a novel strain of coronaviruses reported in Wuhan and spread rapidly al... more In the last days of 2019, a novel strain of coronaviruses reported in Wuhan and spread rapidly all over the world which called 2019 novel coronavirus (2019- nCoV). Almost a few months later in the early 2020 (January 2020), the WHO declared the outbreak of COVID-19 a Public Health Emergency which Compared with the other SARS- CoV, has a stronger transmission capacity. Although respiratory problems are the main clinical symptoms of COVID-19, some patients also experience other conditions and injuries, such as severe vascular damage. Therefore, it can be said that understanding the damage caused by this infection to the vascular system and its underlying mechanisms is of great importance.

Archives of Anesthesia and Critical Care

Background: There are inconclusive data of Ven venous extracorporeal membrane oxygenation (VV‐ECM... more Background: There are inconclusive data of Ven venous extracorporeal membrane oxygenation (VV‐ECMO) VV‐ECMO for a therapeutic strategy for acute respiratory distress syndrome (ARDS). Methods: Totally 28 critically ill patients were included into the study between 23 September 2013 and 20 january 2020. Critically ill adult patients who were refractory to conventional therapeutic modalities were eligible for veno-venous ECMO and study inclusion. Results: Of a total of 28 patients, 15 patients (53.6%) survived and 13 (46.42%) died. Gender frequency had no significant difference between survivors and non-survivors (P=0.07). Mean of age and BMI had no significant differences between the mentioned groups also (P>0.05). It was the same for BSA and the two groups were in the same situation (1.82±0.37 vs. 1.79±0.29; P=0.81). There were no significant differences between survivors and non-survivors regarding ECMO time (114.49±91.05 vs. 162.62±100.17 minutes; P=0.20) and ICU stays (9.65±5.1...

Vaginal discharge syndrome is a clinical condition characterized by leucorrhea, which can be caus... more Vaginal discharge syndrome is a clinical condition characterized by leucorrhea, which can be caused by reproductive tract infections (RTIs). The aim of this study is to identify productive species of vaginal candidiasis in women referred to health centers in Tehran. The Prerana dataset was collected as part of a prospective cohort study of 898 non-pregnant, reproductive-aged women living in and around Iran, between 2013 and 2014. The primary study objective was to evaluate the relationship between abnormal vaginal flora and the incidence of Herpes Simplex Virus-type 2 infection. Participants completed three study visits–conducted at baseline, and at three and six months-each of which involved an interviewer-administered question naire in Tehran, Iran; a pelvic examination; and collection of vaginal and blood specimens for laboratory testing for reproductive tract infections. Analyses investigating separate research aims will be conducted over three papers, as follows: Bacterial vaginosis and risk of Trichomonas vaginalisinfection,and Epidemiologic features of vulvovaginal candidiasis, and Syndromic diagnosis of vaginal infections using logic regression. The Prerana cohort dataset is well-suited to filling in multiple gaps in the research literature. The analyses are among the first to test (or re-test) specific hypotheses concerning vaginal infection using a community-based sample based in a low-income setting.

Tanaffos, 2021

Background: Sustained inflammation has been observed in the majority of severe COVID-19 cases. Th... more Background: Sustained inflammation has been observed in the majority of severe COVID-19 cases. The impact of choice of opioid on perioperative inflammatory processes has not been assessed in the clinical setting. Materials and Methods: Patients with novel coronavirus (COVID-19) who referred to Masih Daneshvari and Noor-Afshar Hospitals in Tehran were included in the study after providing full explanations and obtaining written consent. Patients were then randomly divided into three groups: morphine, fentanyl and control. Patients in the morphine group received 3 mg of morphine intravenously every 6 hours for 5 days, whereas in the fentanyl group, 1.5 mcg / kg / h of fentanyl was infused for 2 hours on 5 consecutive days. The results were evaluated based on the design of the questionnaire and its completion using t-test and SPSS25 software. Results: A total of 127 participants responded to the survey between 20 April and 20 June 2020, of whom 90 (70.86%) with the average age 65.2 yea...

Early diagnosis is very important for fasciolosis and Candidiasis in prevention and control. Two ... more Early diagnosis is very important for fasciolosis and Candidiasis in prevention and control. Two productive species, namely F. hepatica and Candida Albicans of the disease in terms of together morphological similarities in some of the features of a great but the differences. In this study, the presence or absence of similarity between genes raw of Antique excretory - secretory and somatic two species of the parasite and Fungi to Elisa test was evaluated. Crude antigens of both species (including excretory - secretory and SCC) developed and to use in the cold oc -20 were kept. In the preparing the antiserum, antigens with the increasing the dose 0 / 5-2 / 5 in the five times with intervals of seven days, two rabbits were injected. Ten days after the last injection, blood and serum samples after separation, in cold 20 ° C were kept. Reaction of Crude antigen the antiserum any species with the self antiserum (homologous) and as well as antiserum other species (heterologous) evaluated b...

Because of resistance and side effects of common anti-parasite and antifungal drugs, there have b... more Because of resistance and side effects of common anti-parasite and antifungal drugs, there have been many studies on the use of the herbal antifungal Herbal Extract. In this study, the anti-Candida and anti-Fasiola activities of Sage Herb (Salvia Officinalis) extract in comparison with anti-fungal and anti -parasite drugs were examined. The research disc diffusion method was used to study the inhibitory effects of the extract of Sage Herb (Salvia officinalis) and Miconazole, Triclabendazole and fluconazole on species of Candida Albicans and Fasciola Hpatitca, which are isolated from patients who suffered from vulvovaginal candidiasis and Fasciolasis at 25°C and 37°C. The transparent area around the manuscript discs showed that thyme extract has the most effect against Candida Albicans. The inhibitory effects of Sage Herb (Salvia Officinalis) extract on the growth of Candida and Fasciolaat 37°C were better than 25°C. The inhibitory effect of Miconazole, Triclabendazole was better tha...

Biomedical and Biotechnology Research Journal (BBRJ), 2017

Cystic fibrosis (CF) has been generally well defined throughout the world although its prevalence... more Cystic fibrosis (CF) has been generally well defined throughout the world although its prevalence is very difficult to ascertain for a number of reasons, including the fact that the medical/scientific literature and patient registries vary in quality in different countries. In the present review literature (1938–2017), we found out the higher frequency of registered CF patients in the European Union. This could be due to strong clinical awareness and greater health facilities. In contrast, we found a very irregular report from Asian and African countries. In these countries, the national CF registration system is mostly lacking or it is individualized-based research. In this situation, the estimation of various risk factors such as ethnicity and/or races is remained to be resolved. Overall, this review outlines the urgent need for revitalization of national and global CF registration, worldwide.

ACTA MEDICA IRANICA

The severity of COVID-19 disease and its mortality may be due to a localized vascular problem owi... more The severity of COVID-19 disease and its mortality may be due to a localized vascular problem owing to the activation of bradykinin B1 receptors on endothelial cells in the lungs that occur following inflammation. Bromelain acts as an anti-inflammatory factor and can lower the level of bradykinin in the serum and tissues. Patients with the novel coronavirus (COVID-19) referred to Masih Daneshvari Hospital in Tehran were included in the study after providing full explanations and obtaining written consent. The 40 patients with mild to moderate symptoms were randomly divided into the control group (No: 20) and sample (No: 20). In the sample group, a dose of 200 mg bromelain was given to patients every 8 hours. In the control group, placebo capsules were administered exactly at the above intervals. Clinical and paraclinical factors (including SaO2, RR body temperature, MAP, HR, CRP, ESR, AST, ALT, Bil, BUN, Cr, WBC, Lymph, LDH, Plt were evaluated on a regular basis for up to five days....

Archives of Anesthesia and Critical Care, 2021

The rapid expansion of a novel human infectious disease caused by severe acute respiratory syndro... more The rapid expansion of a novel human infectious disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has evolved into a pandemic, affecting thousands of people world wild. Some patients with coronavirus disease 2019 (COVID-19) develop severe infection, which may progress to acute respiratory distress syndrome, multiple organ failure, and death. Increasing studies indicate that abnormal elevation of cytokine levels in response to SARS-CoV-2 may contribute to the pathological process that leads mortality of COVID-19. Thus, application of extracorporeal hemoperfusion (HP) for removal of excessive cytokines from the blood can potentially mitigate or reverse cytokine storm related complications of COVID-19. Here, we presented series of COVID-19 patients, who were treated with HP (HA 380 cartridge, Jafron Biomedocal Co, China). The medical records were evaluated retrospectively to determine the effect of HP on patients’ clinical outcome. Our results showed that H...

International journal of Advanced Biological and Biomedical Research, 2016

The objective of this study was to prepare a suitable form of nanofiber for Nystatin using polyme... more The objective of this study was to prepare a suitable form of nanofiber for Nystatin using polymers Eudragit HPMC (Hydroxy Prapyl Methyl Cellulose) K4M and RS PO and to evaluate the effect of some variables on the characteristics of resulted electrospunnanofibers. Electrospinning process was used for the preparation of nanofibers. Several solutions the combinations of HPMC (Hydroxy Prapyl Methyl Cellulose) K4M, Eudragit RS PO and Ibuprofen in different solvents and various ratios were prepared. The spinning solutions were loaded in 10 mL syringes. The feeding rate was fixed by a syringe pump at 2.0 mL/h and the use a high voltage supply at range 10-18 kV was applied for electrospinning. Electrospunnanofibers were collected and evaluated by scanning electron microscopy, differential scanning calorimetry and FTIR for possible interaction between materials used in nanofibers. The effect of solvent and viscosity on the characteristics of nanofibers also was investigated. Fiber structure...

Biomedical and Biotechnology Research Journal (BBRJ), 2020

Introduction : During cardiopulmonary bypass, oxidative stress happens in the patient's cells... more Introduction : During cardiopulmonary bypass, oxidative stress happens in the patient's cells due to blood contact with various levels of synthetic materials. It can activate inflammatory process and release factors such as IL-6, CRP, and Neutrophils witch may hurt different organs. In recent years, many efforts have been made to prevent this type of damage, however, no single treatment has been proposed to reduce this risk. Antioxidant substances such as Thiamine is important in cell defense against free oxygen radicals. Regarding this issue, in this study, the effect of thiamine on lactate levels in patients undergoing coronary artery bypass graft surgery has been investigated. Materials and methods: In this study, 140 patients from 25 to 65 years old with mild systolic dysfunction (EF = 45-55%) who were candidates for elective CABG surgery in two groups: control and purpose (patients receiving Thiamine) were examined. All of these patients were anesthetized in an identical ma...

Venous air embolism (VAE) is an infrequent incident with fatal consequences during insertion or r... more Venous air embolism (VAE) is an infrequent incident with fatal consequences during insertion or removal of central venous catheters. It is befalling when air or gas arrive the vascular system. In this case report, we present a case of a 38-year-old female patient with an air embolism after removal of Swan Ganz catheter that caused seizure and cardiac arrest. In fact, there is an overview of the causes and ways to prevent VAE in the patient.

Anesthesiology and Pain Medicine

Desmopressin is an analog of the antidiuretic hormone (vasopressin), which causes anticoagulant a... more Desmopressin is an analog of the antidiuretic hormone (vasopressin), which causes anticoagulant activity by increasing plasma factor 8. The use of desmopressin dates back to 1977, when this hormone was used to prevent bleeding during tooth extraction and surgery in patients with hemophilia A and von Willebrand disease. After that, this hormone was expanded to prevent bleeding in congenital defects and conditions such as chronic kidney and liver failure. Also, this hormone is used to prevent bleeding in major surgeries such as heart surgery, where the patient loses much blood and needs a blood transfusion. Considering the importance of desmopressin in bleeding control, the present study was conducted to investigate the possible effect of this hormone in heart surgery.

Iranian Journal of Clinical Infectious Diseases, Sep 24, 2022

Background: The application of methylprednisolone in ARDS patients has led to a sustained reducti... more Background: The application of methylprednisolone in ARDS patients has led to a sustained reduction in inflammatory plasma cytokines and chemokines and has recently been used in the treatment of patients with SARS-CoV-2 infection. Objectives: In this study, the effect of methylprednisolone on clinical symptoms and antioxidant changes of patients with COVID-19 has been investigated. Methods: In the present study, patients with moderate to severe COVID-19 who required hospitalization were entered into the study phase. Then, in addition to standard treatment, patients received methylprednisolone at a dose of 250 mg intravenously over three days. Necessary evaluations include analysis of arterial blood gases, pulse oximetry, monitoring of patient clinical signs, examination of inflammatory biomarkers, and also receiving 10 cc of peripheral blood samples to check for antioxidant changes, at the beginning of the study, after 24 hours, and 72 hours after receiving methylprednisolone was on the agenda. Results: Changes in fever, superoxide dismutase (SOD, Glutathione-S-Transferase (GST, the ferric reducing ability of plasma (FRAP, malondialdehyde (MDA, Nitric oxide, Ferritin, and TNF-α before treatment and 72 hours after treatment were significantly different between the two stages (P < 0.05). Conclusions: The use of methylprednisolone improves the balance of antioxidants and immunological factors in patients with COVID-19 and thus improves some clinical indicators in these patients.

Journal of Iranian Medical Council

Organoids are a miniature, simplified version of a human organ that are produced in three dimensi... more Organoids are a miniature, simplified version of a human organ that are produced in three dimensions in the laboratory and show the true anatomical array. These organelles originate from one or more cells - embryonic stem cells or induced multipotent stem cells - that can organize themselves in three-dimensional culture media. The use of stem cells due to the unlimited capacity of tissue division and regeneration is a great promise as a therapeutic tool. These three-dimensional models of human tissue can be used to test drugs before they are tested on humans. Lung organoids are one of the different types of organoids that, like other organoids, can be formed through a process of self-organizing stem cells or specific parts of an organ. These organoids can also be utilized as a useful tool for screening drugs and vaccines for infections such as the novel SARS-COV-2 infection. The aim of this study was to investigate the potential of lung organoids in the treatment of pulmonary diseas...

Journal of Iranian Medical Council

Background: Hesperidin is a secondary metabolite of the flavonoid group. Due to its antioxidant, ... more Background: Hesperidin is a secondary metabolite of the flavonoid group. Due to its antioxidant, anti-inflammatory and anti-viral properties, it can be helpful as a treatment option for patients with COVID 19. Methods: This study was conducted as a clinical trial in Masih Daneshvari Hospital in Tehran. After providing complete explanations and obtaining written consent, patients with new coronavirus (COVID-19) were included in the study if they met the inclusion criteria. 20 patients with the new coronavirus (COVID-19) were included in the study. Patients were then randomly divided into hesperidin and control groups. Patients in the hesperidin group received 1 mg of hesperidin orally intravenously every 6 hours for 5 days, whereas in the control group, they did not. Then, the desired variables were measured during the research period. Patients were monitored for adverse drug reactions based on clinical symptoms and signs. The results were evaluated with regard to the design of the ...

Archives of Anesthesia and Critical Care

In the last days of 2019, a novel strain of coronaviruses reported in Wuhan and spread rapidly al... more In the last days of 2019, a novel strain of coronaviruses reported in Wuhan and spread rapidly all over the world which called 2019 novel coronavirus (2019- nCoV). Almost a few months later in the early 2020 (January 2020), the WHO declared the outbreak of COVID-19 a Public Health Emergency which Compared with the other SARS- CoV, has a stronger transmission capacity. Although respiratory problems are the main clinical symptoms of COVID-19, some patients also experience other conditions and injuries, such as severe vascular damage. Therefore, it can be said that understanding the damage caused by this infection to the vascular system and its underlying mechanisms is of great importance.

Archives of Anesthesia and Critical Care

Background: There are inconclusive data of Ven venous extracorporeal membrane oxygenation (VV‐ECM... more Background: There are inconclusive data of Ven venous extracorporeal membrane oxygenation (VV‐ECMO) VV‐ECMO for a therapeutic strategy for acute respiratory distress syndrome (ARDS). Methods: Totally 28 critically ill patients were included into the study between 23 September 2013 and 20 january 2020. Critically ill adult patients who were refractory to conventional therapeutic modalities were eligible for veno-venous ECMO and study inclusion. Results: Of a total of 28 patients, 15 patients (53.6%) survived and 13 (46.42%) died. Gender frequency had no significant difference between survivors and non-survivors (P=0.07). Mean of age and BMI had no significant differences between the mentioned groups also (P>0.05). It was the same for BSA and the two groups were in the same situation (1.82±0.37 vs. 1.79±0.29; P=0.81). There were no significant differences between survivors and non-survivors regarding ECMO time (114.49±91.05 vs. 162.62±100.17 minutes; P=0.20) and ICU stays (9.65±5.1...

Vaginal discharge syndrome is a clinical condition characterized by leucorrhea, which can be caus... more Vaginal discharge syndrome is a clinical condition characterized by leucorrhea, which can be caused by reproductive tract infections (RTIs). The aim of this study is to identify productive species of vaginal candidiasis in women referred to health centers in Tehran. The Prerana dataset was collected as part of a prospective cohort study of 898 non-pregnant, reproductive-aged women living in and around Iran, between 2013 and 2014. The primary study objective was to evaluate the relationship between abnormal vaginal flora and the incidence of Herpes Simplex Virus-type 2 infection. Participants completed three study visits–conducted at baseline, and at three and six months-each of which involved an interviewer-administered question naire in Tehran, Iran; a pelvic examination; and collection of vaginal and blood specimens for laboratory testing for reproductive tract infections. Analyses investigating separate research aims will be conducted over three papers, as follows: Bacterial vaginosis and risk of Trichomonas vaginalisinfection,and Epidemiologic features of vulvovaginal candidiasis, and Syndromic diagnosis of vaginal infections using logic regression. The Prerana cohort dataset is well-suited to filling in multiple gaps in the research literature. The analyses are among the first to test (or re-test) specific hypotheses concerning vaginal infection using a community-based sample based in a low-income setting.

Tanaffos, 2021

Background: Sustained inflammation has been observed in the majority of severe COVID-19 cases. Th... more Background: Sustained inflammation has been observed in the majority of severe COVID-19 cases. The impact of choice of opioid on perioperative inflammatory processes has not been assessed in the clinical setting. Materials and Methods: Patients with novel coronavirus (COVID-19) who referred to Masih Daneshvari and Noor-Afshar Hospitals in Tehran were included in the study after providing full explanations and obtaining written consent. Patients were then randomly divided into three groups: morphine, fentanyl and control. Patients in the morphine group received 3 mg of morphine intravenously every 6 hours for 5 days, whereas in the fentanyl group, 1.5 mcg / kg / h of fentanyl was infused for 2 hours on 5 consecutive days. The results were evaluated based on the design of the questionnaire and its completion using t-test and SPSS25 software. Results: A total of 127 participants responded to the survey between 20 April and 20 June 2020, of whom 90 (70.86%) with the average age 65.2 yea...

Early diagnosis is very important for fasciolosis and Candidiasis in prevention and control. Two ... more Early diagnosis is very important for fasciolosis and Candidiasis in prevention and control. Two productive species, namely F. hepatica and Candida Albicans of the disease in terms of together morphological similarities in some of the features of a great but the differences. In this study, the presence or absence of similarity between genes raw of Antique excretory - secretory and somatic two species of the parasite and Fungi to Elisa test was evaluated. Crude antigens of both species (including excretory - secretory and SCC) developed and to use in the cold oc -20 were kept. In the preparing the antiserum, antigens with the increasing the dose 0 / 5-2 / 5 in the five times with intervals of seven days, two rabbits were injected. Ten days after the last injection, blood and serum samples after separation, in cold 20 ° C were kept. Reaction of Crude antigen the antiserum any species with the self antiserum (homologous) and as well as antiserum other species (heterologous) evaluated b...

Because of resistance and side effects of common anti-parasite and antifungal drugs, there have b... more Because of resistance and side effects of common anti-parasite and antifungal drugs, there have been many studies on the use of the herbal antifungal Herbal Extract. In this study, the anti-Candida and anti-Fasiola activities of Sage Herb (Salvia Officinalis) extract in comparison with anti-fungal and anti -parasite drugs were examined. The research disc diffusion method was used to study the inhibitory effects of the extract of Sage Herb (Salvia officinalis) and Miconazole, Triclabendazole and fluconazole on species of Candida Albicans and Fasciola Hpatitca, which are isolated from patients who suffered from vulvovaginal candidiasis and Fasciolasis at 25°C and 37°C. The transparent area around the manuscript discs showed that thyme extract has the most effect against Candida Albicans. The inhibitory effects of Sage Herb (Salvia Officinalis) extract on the growth of Candida and Fasciolaat 37°C were better than 25°C. The inhibitory effect of Miconazole, Triclabendazole was better tha...

Biomedical and Biotechnology Research Journal (BBRJ), 2017

Cystic fibrosis (CF) has been generally well defined throughout the world although its prevalence... more Cystic fibrosis (CF) has been generally well defined throughout the world although its prevalence is very difficult to ascertain for a number of reasons, including the fact that the medical/scientific literature and patient registries vary in quality in different countries. In the present review literature (1938–2017), we found out the higher frequency of registered CF patients in the European Union. This could be due to strong clinical awareness and greater health facilities. In contrast, we found a very irregular report from Asian and African countries. In these countries, the national CF registration system is mostly lacking or it is individualized-based research. In this situation, the estimation of various risk factors such as ethnicity and/or races is remained to be resolved. Overall, this review outlines the urgent need for revitalization of national and global CF registration, worldwide.

ACTA MEDICA IRANICA

The severity of COVID-19 disease and its mortality may be due to a localized vascular problem owi... more The severity of COVID-19 disease and its mortality may be due to a localized vascular problem owing to the activation of bradykinin B1 receptors on endothelial cells in the lungs that occur following inflammation. Bromelain acts as an anti-inflammatory factor and can lower the level of bradykinin in the serum and tissues. Patients with the novel coronavirus (COVID-19) referred to Masih Daneshvari Hospital in Tehran were included in the study after providing full explanations and obtaining written consent. The 40 patients with mild to moderate symptoms were randomly divided into the control group (No: 20) and sample (No: 20). In the sample group, a dose of 200 mg bromelain was given to patients every 8 hours. In the control group, placebo capsules were administered exactly at the above intervals. Clinical and paraclinical factors (including SaO2, RR body temperature, MAP, HR, CRP, ESR, AST, ALT, Bil, BUN, Cr, WBC, Lymph, LDH, Plt were evaluated on a regular basis for up to five days....

Archives of Anesthesia and Critical Care, 2021

The rapid expansion of a novel human infectious disease caused by severe acute respiratory syndro... more The rapid expansion of a novel human infectious disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has evolved into a pandemic, affecting thousands of people world wild. Some patients with coronavirus disease 2019 (COVID-19) develop severe infection, which may progress to acute respiratory distress syndrome, multiple organ failure, and death. Increasing studies indicate that abnormal elevation of cytokine levels in response to SARS-CoV-2 may contribute to the pathological process that leads mortality of COVID-19. Thus, application of extracorporeal hemoperfusion (HP) for removal of excessive cytokines from the blood can potentially mitigate or reverse cytokine storm related complications of COVID-19. Here, we presented series of COVID-19 patients, who were treated with HP (HA 380 cartridge, Jafron Biomedocal Co, China). The medical records were evaluated retrospectively to determine the effect of HP on patients’ clinical outcome. Our results showed that H...

International journal of Advanced Biological and Biomedical Research, 2016

The objective of this study was to prepare a suitable form of nanofiber for Nystatin using polyme... more The objective of this study was to prepare a suitable form of nanofiber for Nystatin using polymers Eudragit HPMC (Hydroxy Prapyl Methyl Cellulose) K4M and RS PO and to evaluate the effect of some variables on the characteristics of resulted electrospunnanofibers. Electrospinning process was used for the preparation of nanofibers. Several solutions the combinations of HPMC (Hydroxy Prapyl Methyl Cellulose) K4M, Eudragit RS PO and Ibuprofen in different solvents and various ratios were prepared. The spinning solutions were loaded in 10 mL syringes. The feeding rate was fixed by a syringe pump at 2.0 mL/h and the use a high voltage supply at range 10-18 kV was applied for electrospinning. Electrospunnanofibers were collected and evaluated by scanning electron microscopy, differential scanning calorimetry and FTIR for possible interaction between materials used in nanofibers. The effect of solvent and viscosity on the characteristics of nanofibers also was investigated. Fiber structure...

Biomedical and Biotechnology Research Journal (BBRJ), 2020

Introduction : During cardiopulmonary bypass, oxidative stress happens in the patient's cells... more Introduction : During cardiopulmonary bypass, oxidative stress happens in the patient's cells due to blood contact with various levels of synthetic materials. It can activate inflammatory process and release factors such as IL-6, CRP, and Neutrophils witch may hurt different organs. In recent years, many efforts have been made to prevent this type of damage, however, no single treatment has been proposed to reduce this risk. Antioxidant substances such as Thiamine is important in cell defense against free oxygen radicals. Regarding this issue, in this study, the effect of thiamine on lactate levels in patients undergoing coronary artery bypass graft surgery has been investigated. Materials and methods: In this study, 140 patients from 25 to 65 years old with mild systolic dysfunction (EF = 45-55%) who were candidates for elective CABG surgery in two groups: control and purpose (patients receiving Thiamine) were examined. All of these patients were anesthetized in an identical ma...

Venous air embolism (VAE) is an infrequent incident with fatal consequences during insertion or r... more Venous air embolism (VAE) is an infrequent incident with fatal consequences during insertion or removal of central venous catheters. It is befalling when air or gas arrive the vascular system. In this case report, we present a case of a 38-year-old female patient with an air embolism after removal of Swan Ganz catheter that caused seizure and cardiac arrest. In fact, there is an overview of the causes and ways to prevent VAE in the patient.