Sheu Quadri Rahamon | University of Ibadan (original) (raw)

Papers by Sheu Quadri Rahamon

European Journal of General Medicine, 2014

Experimental studies have shown numerous health disorders associated with occupational exposure t... more Experimental studies have shown numerous health disorders associated with occupational exposure to organophosphate pesticides but evidence of impaired immune functions by pesticides in humans is scarce. This study determined complete blood count (CBC), serum immunoglobulin classes (IgE, IgA, IgM, IgG),acetylcholinesterase (AChE) activity and skin sensitivity prick test to common environmental allergens in 60 farm workers (30 pesticide applicators and 30 farmers) exposed to organophosphate (OP) pesticides compared with30 apparently healthy, non-exposed workers. Serum AChE activity, mean PCV level, total white blood cell count (TWBC) and neutrophil count were significantly reduced while the mean lymphocyte count and eosinophil count were significantly raised in both pesticides applicators (PA) and farmers compared with controls. However, mean monocyte count was significantly raised in PA compared with controls. Also, serum activityof AChE and mean serum IgM level were significantly reduced while the mean monocyte count was significantly raised in PA compared with farmers. This study shows that pesticides applicators are more exposed to effects of organophosphate than farmers.

Nigerian journal of physiological sciences : official publication of the Physiological Society of Nigeria, 2013

World Health Organisation estimated that about 80% of Africans use herbal remedies for illness. H... more World Health Organisation estimated that about 80% of Africans use herbal remedies for illness. Human immunodeficiency virus (HIV) infection which was believed to have no cure led many HIV patients to source for alternative or complementary therapy. A structured questionnaire was administered to 640 HIV patients in selected Nigerian HIV/AIDS clinics from 2009 to 2011 to assess their attitudes to the use of herbal remedy. Six hundred and ten (610) of the respondents were diagnosed by medical doctor and 6.3% (40) had lived with HIV for 4 years and above. Twenty (20) respondents had sought for medical therapy after diagnosis, 310 applied herbal remedy and 180 of the respondents opted for spiritual solutions. Although, majority (73.4%) would denied the use of herbal remedy when asked by a medical practitioner, 100 respondents combines herbal remedy with HAART and 67.2% of the entire respondents are of the opinion that herbal therapy is effective in HIV infection management. 64.1% of the...

European Journal of General Medicine, 2014

Background: The interaction between vitamin D deficiency (VDD) and dysfunction of both the kidney... more Background: The interaction between vitamin D deficiency (VDD) and dysfunction of both the kidney and liver is still poorly understood in different health states of SCA. This study determined serum levels of vitamin D and indices of liver and renal function in adult sickle cell anaemia subjects. Methods: Sixty subjects with sickle cell anaemia (30 in steady state [SSCA] and 30 in vaso-occlusive crisis [VOC]) and 30 apparently healthy individuals with HbAA genotype were recruited into this study. Standard methods were used for the determination of total protein, albumin, bilirubin, urinary creatinine and albumin while serum vitamin D was determined using ELISA. Differences between groups were determined using Student’s t-test or Man-Whitney U test as appropriate. P<0.05 was considered as statistically significant. Results: Serum vitamin D was significantly lower in sickle cell anemia (SCA) subjects and the deficiency was more profound in VOC when compared with the control subjects...

Nigerian Medical Journal, 2014

Background: Abnormal lipid homeostasis has been reported in sickle cell anaemia (SCA) as well as ... more Background: Abnormal lipid homeostasis has been reported in sickle cell anaemia (SCA) as well as in other haematological disorders. However, there is little information on the lipid profile of SCA subjects in vaso-occlusive crisis (VOC). This study determined the lipid profile of adult SCA subjects in VOC and in steady state (SSCA). Materials and Methods: Fifty-eight (58) adults with HbSS (30 in steady state and 28 in vaso-occlusive crisis) and 24 age-matched healthy individuals with HbAA genotype were recruited into this study. Standard methods were used for the determination of blood pressure (BP), packed cell volume (PCV), total white blood cell count (WBC) and haemoglobin phenotype. After an overnight fast, 5 ml of venous blood was obtained from each SSCA and the controls while samples were collected upon admission in the VOC group. Plasma lipid profile was determined using enzymatic method. Differences between two groups were determined using independent Student's t-test or Man-Whitney U as appropriate. P-values less than 0.05 were considered significant. Results: Plasma total cholesterol (TC) and high density lipoprotein (HDL) were significantly lower while the ratio of triglyceride (TG) to HDL (TG/HDL) was significantly higher in SSCA compared with the controls. Low density lipoprotein (LDL) and TC were significantly lower in SCA subjects in VOC compared with controls. However, TC, TG, LDL and TG/HDL were significantly lower while HDL was significantly higher in VOC compared with SSCA. Conclusion: Sickle cell anaemia subjects have defective fasting lipid metabolism which becomes pronounced with VOC.

European Journal of General Medicine, Jun 1, 2014

ABSTRACT Experimental studies have shown numerous health disorders associated with occupational e... more ABSTRACT Experimental studies have shown numerous health disorders associated with occupational exposure to organophosphate pesticides but evidence of impaired immune functions by pesticides in humans is scarce. This study determined complete blood count (CBC), serum immunoglobulin classes (IgE, IgA, IgM, IgG),acetylcholinesterase (AChE) activity and skin sensitivity prick test to common environmental allergens in 60 farm workers (30 pesticide applicators and 30 farmers) exposed to organophosphate (OP) pesticides compared with30 apparently healthy, non-exposed workers. Serum AChE activity, mean PCV level, total white blood cell count (TWBC) and neutrophil count were significantly reduced while the mean lymphocyte count and eosinophil count were significantly raised in both pesticides applicators (PA) and farmers compared with controls. However, mean monocyte count was significantly raised in PA compared with controls. Also, serum activityof AChE and mean serum IgM level were significantly reduced while the mean monocyte count was significantly raised in PA compared with farmers. This study shows that pesticides applicators are more exposed to effects of organophosphate than farmers. Key words: Farm workers, immunosuppression, organophosphate exposure, pesticide applicators

The interaction between vitamin D deficiency (VDD) and dysfunction of both the kidney and liver i... more The interaction between vitamin D deficiency (VDD) and dysfunction of both the kidney and liver is still poorly understood in different
health states of SCA. This study determined serum levels of vitamin D and indices of liver and renal function in adult sickle cell anaemia
subjects. Sixty subjects with sickle cell anaemia (30 in steady state [SSCA] and 30 in vaso-occlusive crisis [VOC]) and 30 apparently
healthy individuals with HbAA genotype were recruited into this study. Standard methods were used for the determination of total protein,
albumin, bilirubin, urinary creatinine and albumin while serum vitamin D was determined using ELISA. Differences between groups were
determined using Student’s t-test or Man-Whitney U test as appropriate with p<0.05 considered as statistically significant. Serum vitamin D
was significantly lower in sickle cell anemia (SCA) subjects and the deficiency was more profound in VOC when compared with the control
subjects. SCA subjects with vitamin D level <50 nmol/L had significantly higher levels of total bilirubin (TBIL) and conjugated bilirubin
(CBIL) compared with those who had ≥50 nmol/L vitamin D level. There was no significant difference in vitamin D level between SCA
subjects with one or less episode of SCA crisis per year and SCA subjects with two or more episodes of SCA crisis per year although, the
median vitamin D level was lower in the latter. Vitamin D deficiency is more pronounced in SCA subjects in vaso-occlusive crisis and
elevated serum bilirubin was observed in SCA subjects with low serum vitamin D level.

Objective: This study assessed the diagnostic performance and prognostic properties of C-reactive... more Objective: This study assessed the diagnostic performance and prognostic properties of C-reactive protein (CRP), copeptin
and cortisol in individuals with sickle cell anaemia (SCA).
Design: Prospective case-control study
Methods: Sixty consecutive SCA subjects (18–40 years) comprising 30 subjects in the steady state and 30 subjects in vasoocclusive
crisis (VOC) were recruited into this study. Thirty (30) apparently healthy individuals with HbAA genotype served
as controls. ELISA was used for the determination of serum levels of copeptin, CRP and cortisol. Data obtained were
statistically analyzed using the Student’s t-test and Mann Whitney U as appropriate and P,0.05 was considered significant.
Results: SCA subjects in VOC had significantly lower copeptin level and significantly higher CRP level compared with
controls. However, serum levels of copeptin, cortisol and CRP were significantly higher in SCA subjects in VOC compared
with SCA subjects in steady state. Furthermore, CRP had the widest Area under the ROC curve (AUROC) than copeptin and
cortisol. No significant difference was observed in the levels of copeptin, CRP and cortisol when SCA subjects in VOC who
were hospitalized for less #5 days were compared with subjects who had longer stays.
Conclusion: It could be concluded that C-reactive protein has a superior diagnostic performance for vaso-occlusive crisis in
individuals with sickle cell anaemia and that C-reactive protein, cortisol and copeptin are not good prognostic markers in SCA subjects in vaso-occlusive crisis.

It is well known that individuals with SCA undergo constant physiological stress even, in steady ... more It is well known that individuals with SCA undergo constant physiological stress even, in steady state.
However, there is little information on the relationship between the severity of sickle cell anaemia (SCA) and serum levels
of biomarkers of stress. This study therefore determined the serum levels of copeptin, cortisol and CRP in adults with SCA
in different severity groups. Sixty adults with sickle cell anaemia in steady state (27.1±6.3 years) and in vaso-occlusive
crisis (24.9±4.9 years) were recruited into this cross-sectional study. Degree of severity (mild, moderate or severe) was
determined using a scoring system incorporating annual number of blood transfusions, crisis and presence of anaemia,
vaso-occlusive pain and organ complications. Standard methods were used for the determination of packed cell volume
(PCV), total white blood cell count (WBC), blood pressure measurements and anthropometric indices. Serum levels of
copeptin, cortisol and CRP were determined using ELISA with the ratios calculated accordingly. Data obtained were
statistically analyzed using the Student’s t-test, Mann Whitney U and Chi-square test as appropriate. P<0.05 was
considered significant. The mean systolic blood pressure (SBP) and copeptin level were significantly higher in subjects
with moderate SCA compared with those with mild SCA. Similarly SBP, pulse, WBC, copeptin and cortisol were
significantly higher while body weight was significantly lower in subjects with severe SCA compared with subjects with
mild SCA. However, WBC and cortisol-to-copeptin ratio were significantly higher in subjects with severe SCA compared
with subjects with moderate SCA. There was progressive rise in serum levels of CRP from mild SCA through severe SCA
but the differences were not statistically significant. Also, proportions of subjects with elevated SBP and WBC were higher
than the proportion of subjects with lower SBP and WBC in the severe SCA group. Serum levels of cortisol, copeptin, and
their ratio could differentiate severe SCA from mild or moderate SCA. Also, elevated systolic blood pressure and total
white blood cell count are associated with severe sickle cell anaemia.

European Journal of General Medicine, 2014

Nigerian journal of physiological sciences : official publication of the Physiological Society of Nigeria, 2013

European Journal of General Medicine, 2014

Nigerian Medical Journal, 2014

European Journal of General Medicine, Jun 1, 2014