McM Young | Instituto de Botânica de São Paulo - Brazil (original) (raw)

Papers by McM Young

Research paper thumbnail of Antifungi propiophenones of Piper marginatum leaves

Research paper thumbnail of New iridoids and dry-iridoids from Calycophyllum spruceanum (Rubiaceae)

Research paper thumbnail of Chemical constituents of stems from Michelia champaca L. (Magnoliaceae)

Eclética Química (Araraquara), 2007

Resumo: O fracionamento cromatográfico da fase diclorometânica dos caules de Michelia champaca, f... more Resumo: O fracionamento cromatográfico da fase diclorometânica dos caules de Michelia champaca, forneceu quatro substâncias: álcool 4-O-β-D-glicopiranosídeo sinapílico, aldeído 4-O-β-D-glicopiranosídeo sinápico, siringaresinol e N-acetilnonaina. Extração ácido-base de uma nova porção do extrato bruto etanólico permitiu a identificação do alcalóide liriodenina. Os derivados fenilpropanoídicos e o alcalóide N-acetilnonaina estão sendo descritos pela primeira vez no gênero Michelia. O alcalóide liriodenina e a lignana siringaresinol apresentaram atividade antifúngica moderada. Palavras-chave: Magnoliaceae; Michelia champaca; alcalóides; atividade antifúngica.

Research paper thumbnail of Antifungal constituents from the roots of Piper dilatatum Rich

Journal of Chemistry, 2013

The compounds (+)-(7S,8R)-epoxy-5,6-didehydrokavain (1), flavokavain B (2), -sitosterol (3), and ... more The compounds (+)-(7S,8R)-epoxy-5,6-didehydrokavain (1), flavokavain B (2), -sitosterol (3), and stigmasterol (4) are reported here as chemical constituents of Piper dilatatum Rich. (Piperaceae). Their structures were determined on the basis of their spectroscopic data ( 1 H and 13 C NMR, MS, and IR). The antifungal activities of pyrone 1 (1 g) and chalcone 2 (100 g) were determined by means of direct bioautography against Cladosporium cladosporioides and C. sphaerospermum. Results indicate P. dilatatum as a candidate for the development of novel antifungal phytotherapic products as well as point out pyrone 1 as a promising hit compound in the quest for novel antifungal agents.

Research paper thumbnail of Antifungal piperolides, coumarins, pyrones and amides from Piper species and synthetic analogs

Research paper thumbnail of Caldensinic acid, a prenylated benzoic acid from Piper caldense

Phytochemistry Letters, 2009

The CH 2 Cl 2 and MeOH extracts from leaves of Piper caldense were subjected to chromatographic s... more The CH 2 Cl 2 and MeOH extracts from leaves of Piper caldense were subjected to chromatographic separation procedures to afford the new prenylated benzoic acid, caldensinic acid (3-[(2 0 E,6 0 E,10 0 E)-11 0carboxy-3 0 ,7 0 ,15 0 -trimethylhexadeca-2 0 ,6 0 ,10 0 ,14 0 -tetraenyl]-4,5-dihydroxybenzoic acid) whose structure was determined by spectral analysis, mainly NMR ( 1 H, 13 C, HSQC, HMBC) and ESI-MS. The natural compound and derivatives displayed antifungal activity against the phytopathogenic fungi Cladosporium cladosporioides and C. sphaerospermum by direct bioautography.

Research paper thumbnail of Antifungal polysulphides from Petiveria alliacea L

Phytochemistry, 2001

Bioactivity-directed fractionation of the CH(2)Cl(2)/MeOH (2:1, v/v) extract of the roots of Peti... more Bioactivity-directed fractionation of the CH(2)Cl(2)/MeOH (2:1, v/v) extract of the roots of Petiveria alliacea, using mutant yeast strains of Saccharomyces cerevisiae and fungi Cladosporium cladosporioides and C. sphaerospermum led to the isolation of dipropyl disulphide (1), dibenzyl sulphide (2), dibenzyl disulphide (3), dibenzyl trisulphide (4), dibenzyl tetrasulphide (5), benzylhydroxymethyl sulphide (6) and di(benzyltrithio) methane (7). Of these, 5-7 are new compounds and this is the first report of the natural occurrence of 2 and 3.

Research paper thumbnail of A new antifungal phenolic glycoside derivative, iridoids and lignans from Alibertia sessilis (vell.) k. schum. (Rubiaceae)

Journal of the Brazilian Chemical Society, 2007

Um novo derivado fenólico glucosilado antifúngico, 3,4,5-trimetoxifenil-1-O-β-D-(5-Osiringoila)-a... more Um novo derivado fenólico glucosilado antifúngico, 3,4,5-trimetoxifenil-1-O-β-D-(5-Osiringoila)-apiofuranosil-(1→6)-β-D-glicopiranosideo (1), juntamente com quatro iridóides conhecidos, ácido geniposídico (2), geniposídeo (3), 6α-hidroxigeniposideo (4) e 6βhidroxigeniposideo (5); duas lignanas, (+)-lioniresinol-3α-O-β-D-glicopiranosideo (6), (-)lioniresinol-3α-O-β-D-glicopiranosideo (7); e dois ácidos fenólicos, ácidos clorogênico (8) e salicílico (9) e D-manitol (10), foram isolados do extrato etanólico dos galhos de Alibertia sessilis. As estruturas de 1 e dos compostos conhecidos foram determinadas por análise espectroscópica. Todos os compostos isolados foram avaliados quanto à atividade antifúngica frente aos dois fungos fitopatogênicos Cladosporium cladosporioides e C. sphaerospermum por bioautografia direta.

Research paper thumbnail of Phytoalexin induction in plants of tropical environment

Biochemical Systematics and Ecology, 1986

Key Word Index--Phytoalexins; dicotyledons; tropical plants; cultivated plants.

Research paper thumbnail of Effects of (−) mammea A/BB isolated from< i> Calophyllum brasiliense</i> leaves and derivatives on mitochondrial membrane of< i> Leishmania amazonensis</i>

Research paper thumbnail of Caldensinic acid, a prenylated benzoic acid from< i> Piper caldense</i>

The CH 2 Cl 2 and MeOH extracts from leaves of Piper caldense were subjected to chromatographic s... more The CH 2 Cl 2 and MeOH extracts from leaves of Piper caldense were subjected to chromatographic separation procedures to afford the new prenylated benzoic acid, caldensinic acid (3-[(2 0 E,6 0 E,10 0 E)-11 0carboxy-3 0 ,7 0 ,15 0 -trimethylhexadeca-2 0 ,6 0 ,10 0 ,14 0 -tetraenyl]-4,5-dihydroxybenzoic acid) whose structure was determined by spectral analysis, mainly NMR ( 1 H, 13 C, HSQC, HMBC) and ESI-MS. The natural compound and derivatives displayed antifungal activity against the phytopathogenic fungi Cladosporium cladosporioides and C. sphaerospermum by direct bioautography.

Research paper thumbnail of Antifungi propiophenones of Piper marginatum leaves

Research paper thumbnail of New iridoids and dry-iridoids from Calycophyllum spruceanum (Rubiaceae)

Research paper thumbnail of Chemical constituents of stems from Michelia champaca L. (Magnoliaceae)

Eclética Química (Araraquara), 2007

Resumo: O fracionamento cromatográfico da fase diclorometânica dos caules de Michelia champaca, f... more Resumo: O fracionamento cromatográfico da fase diclorometânica dos caules de Michelia champaca, forneceu quatro substâncias: álcool 4-O-β-D-glicopiranosídeo sinapílico, aldeído 4-O-β-D-glicopiranosídeo sinápico, siringaresinol e N-acetilnonaina. Extração ácido-base de uma nova porção do extrato bruto etanólico permitiu a identificação do alcalóide liriodenina. Os derivados fenilpropanoídicos e o alcalóide N-acetilnonaina estão sendo descritos pela primeira vez no gênero Michelia. O alcalóide liriodenina e a lignana siringaresinol apresentaram atividade antifúngica moderada. Palavras-chave: Magnoliaceae; Michelia champaca; alcalóides; atividade antifúngica.

Research paper thumbnail of Antifungal constituents from the roots of Piper dilatatum Rich

Journal of Chemistry, 2013

The compounds (+)-(7S,8R)-epoxy-5,6-didehydrokavain (1), flavokavain B (2), -sitosterol (3), and ... more The compounds (+)-(7S,8R)-epoxy-5,6-didehydrokavain (1), flavokavain B (2), -sitosterol (3), and stigmasterol (4) are reported here as chemical constituents of Piper dilatatum Rich. (Piperaceae). Their structures were determined on the basis of their spectroscopic data ( 1 H and 13 C NMR, MS, and IR). The antifungal activities of pyrone 1 (1 g) and chalcone 2 (100 g) were determined by means of direct bioautography against Cladosporium cladosporioides and C. sphaerospermum. Results indicate P. dilatatum as a candidate for the development of novel antifungal phytotherapic products as well as point out pyrone 1 as a promising hit compound in the quest for novel antifungal agents.

Research paper thumbnail of Antifungal piperolides, coumarins, pyrones and amides from Piper species and synthetic analogs

Research paper thumbnail of Caldensinic acid, a prenylated benzoic acid from Piper caldense

Phytochemistry Letters, 2009

The CH 2 Cl 2 and MeOH extracts from leaves of Piper caldense were subjected to chromatographic s... more The CH 2 Cl 2 and MeOH extracts from leaves of Piper caldense were subjected to chromatographic separation procedures to afford the new prenylated benzoic acid, caldensinic acid (3-[(2 0 E,6 0 E,10 0 E)-11 0carboxy-3 0 ,7 0 ,15 0 -trimethylhexadeca-2 0 ,6 0 ,10 0 ,14 0 -tetraenyl]-4,5-dihydroxybenzoic acid) whose structure was determined by spectral analysis, mainly NMR ( 1 H, 13 C, HSQC, HMBC) and ESI-MS. The natural compound and derivatives displayed antifungal activity against the phytopathogenic fungi Cladosporium cladosporioides and C. sphaerospermum by direct bioautography.

Research paper thumbnail of Antifungal polysulphides from Petiveria alliacea L

Phytochemistry, 2001

Bioactivity-directed fractionation of the CH(2)Cl(2)/MeOH (2:1, v/v) extract of the roots of Peti... more Bioactivity-directed fractionation of the CH(2)Cl(2)/MeOH (2:1, v/v) extract of the roots of Petiveria alliacea, using mutant yeast strains of Saccharomyces cerevisiae and fungi Cladosporium cladosporioides and C. sphaerospermum led to the isolation of dipropyl disulphide (1), dibenzyl sulphide (2), dibenzyl disulphide (3), dibenzyl trisulphide (4), dibenzyl tetrasulphide (5), benzylhydroxymethyl sulphide (6) and di(benzyltrithio) methane (7). Of these, 5-7 are new compounds and this is the first report of the natural occurrence of 2 and 3.

Research paper thumbnail of A new antifungal phenolic glycoside derivative, iridoids and lignans from Alibertia sessilis (vell.) k. schum. (Rubiaceae)

Journal of the Brazilian Chemical Society, 2007

Um novo derivado fenólico glucosilado antifúngico, 3,4,5-trimetoxifenil-1-O-β-D-(5-Osiringoila)-a... more Um novo derivado fenólico glucosilado antifúngico, 3,4,5-trimetoxifenil-1-O-β-D-(5-Osiringoila)-apiofuranosil-(1→6)-β-D-glicopiranosideo (1), juntamente com quatro iridóides conhecidos, ácido geniposídico (2), geniposídeo (3), 6α-hidroxigeniposideo (4) e 6βhidroxigeniposideo (5); duas lignanas, (+)-lioniresinol-3α-O-β-D-glicopiranosideo (6), (-)lioniresinol-3α-O-β-D-glicopiranosideo (7); e dois ácidos fenólicos, ácidos clorogênico (8) e salicílico (9) e D-manitol (10), foram isolados do extrato etanólico dos galhos de Alibertia sessilis. As estruturas de 1 e dos compostos conhecidos foram determinadas por análise espectroscópica. Todos os compostos isolados foram avaliados quanto à atividade antifúngica frente aos dois fungos fitopatogênicos Cladosporium cladosporioides e C. sphaerospermum por bioautografia direta.

Research paper thumbnail of Phytoalexin induction in plants of tropical environment

Biochemical Systematics and Ecology, 1986

Key Word Index--Phytoalexins; dicotyledons; tropical plants; cultivated plants.

Research paper thumbnail of Effects of (−) mammea A/BB isolated from< i> Calophyllum brasiliense</i> leaves and derivatives on mitochondrial membrane of< i> Leishmania amazonensis</i>

Research paper thumbnail of Caldensinic acid, a prenylated benzoic acid from< i> Piper caldense</i>

The CH 2 Cl 2 and MeOH extracts from leaves of Piper caldense were subjected to chromatographic s... more The CH 2 Cl 2 and MeOH extracts from leaves of Piper caldense were subjected to chromatographic separation procedures to afford the new prenylated benzoic acid, caldensinic acid (3-[(2 0 E,6 0 E,10 0 E)-11 0carboxy-3 0 ,7 0 ,15 0 -trimethylhexadeca-2 0 ,6 0 ,10 0 ,14 0 -tetraenyl]-4,5-dihydroxybenzoic acid) whose structure was determined by spectral analysis, mainly NMR ( 1 H, 13 C, HSQC, HMBC) and ESI-MS. The natural compound and derivatives displayed antifungal activity against the phytopathogenic fungi Cladosporium cladosporioides and C. sphaerospermum by direct bioautography.